Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
Authors
Keywords
Arg1, Arg2, Arginase, Arginine, Checkpoint blockade, Granulocyte, Immunotherapy, Myeloid derived suppressor cell, Tumor associated macrophage, Tumor microenvironment
Journal
Journal for ImmunoTherapy of Cancer
Volume 5, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-12-15
DOI
10.1186/s40425-017-0308-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The next generation of immunotherapy: keeping lung cancer in check
- (2017) Ashwin Somasundaram et al. Journal of Hematology & Oncology
- Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
- (2017) Naomi McGovern et al. NATURE
- Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
- (2017) Kathrin Renner et al. Frontiers in Immunology
- T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells
- (2016) Ilaria Marigo et al. CANCER CELL
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
- (2016) Willy Hugo et al. CELL
- Immune suppressive mechanisms in the tumor microenvironment
- (2016) David H Munn et al. CURRENT OPINION IN IMMUNOLOGY
- T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions
- (2016) Lee-Ann Van de Velde et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer
- (2016) Emma Eriksson et al. Journal of Translational Medicine
- Emerging concepts of T cell metabolism as a target of immunotherapy
- (2016) Chih-Hao Chang et al. NATURE IMMUNOLOGY
- Macrophages and Therapeutic Resistance in Cancer
- (2015) Brian Ruffell et al. CANCER CELL
- Myeloid Cells as Targets for Therapy in Solid Tumors
- (2015) Tiziana Cotechini et al. CANCER JOURNAL
- The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma
- (2015) Kathleen M. Mahoney et al. CLINICAL THERAPEUTICS
- Amino acid auxotrophy as a system of immunological control nodes
- (2015) Peter J Murray NATURE IMMUNOLOGY
- The prognostic landscape of genes and infiltrating immune cells across human cancers
- (2015) Andrew J Gentles et al. NATURE MEDICINE
- The Next Hurdle in Cancer Immunotherapy: Overcoming the Non–T-Cell–Inflamed Tumor Microenvironment
- (2015) Thomas F. Gajewski SEMINARS IN ONCOLOGY
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- Immunological off-target effects of standard treatments in gastrointestinal cancers
- (2013) A. G. Duffy et al. ANNALS OF ONCOLOGY
- Enhancement of Antitumor Immunity in Lung Cancer by Targeting Myeloid-Derived Suppressor Cell Pathways
- (2013) A. Sawant et al. CANCER RESEARCH
- Myeloid derived suppressor cells
- (2013) Todd J. Waldron et al. OncoImmunology
- Rational combinations of immunotherapeutics that target discrete pathways
- (2013) Stefani Spranger et al. Journal for ImmunoTherapy of Cancer
- Clinical Perspectives on Targeting of Myeloid Derived Suppressor Cells in the Treatment of Cancer
- (2013) Yana G. Najjar et al. Frontiers in Oncology
- Altered functions of natural killer cells in response to L-Arginine availability
- (2012) Bruno Lamas et al. CELLULAR IMMUNOLOGY
- Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension
- (2010) Teddy Bagnost et al. CARDIOVASCULAR RESEARCH
- Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes
- (2009) Paulo C. Rodriguez et al. CANCER RESEARCH
- IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer
- (2009) Rita Rotondo et al. INTERNATIONAL JOURNAL OF CANCER
- Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
- (2008) Karim C El Kasmi et al. NATURE IMMUNOLOGY
- Red blood cell arginase suppresses Jurkat (T cell) proliferation by depleting arginine
- (2007) Andrew Bernard et al. SURGERY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search