Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer

Visualizing and interpreting cancer genomics data via the Xena platform

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Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

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Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

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Recent advances in triple negative breast cancer: the immunotherapy era

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Microenvironmental Metabolism Regulates Antitumor Immunity

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T Cell Activation Depends on Extracellular Alanine

(2019) Noga Ron-Harel et al.   Cell Reports

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

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Asparagine and Glutamine: Co-conspirators Fueling Metastasis

(2018) Ming Luo et al.   Cell Metabolism

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

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Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

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Endothelial Cell Metabolism in Health and Disease

(2018) Katerina Rohlenova et al.   TRENDS IN CELL BIOLOGY

Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets

(2018) Ádám Nagy et al.   Scientific Reports

Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

(2018) Angelika Bröer et al.   Frontiers in Pharmacology

The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation

(2018) Junpei Suzuki et al.   Nature Communications

Reinforce the antitumor activity of CD8+ T cells via glutamine restriction

(2018) Shogo Nabe et al.   CANCER SCIENCE

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Cytotoxic tumour-infiltrating T lymphocytes influence outcome in resected pancreatic ductal adenocarcinoma

(2017) Philipp Lohneis et al.   EUROPEAN JOURNAL OF CANCER

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

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The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ

(2017) Deanna N. Edwards et al.   Science Signaling

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

(2017) Erika M. Palmieri et al.   Cell Reports

Role of tumor microenvironment in tumorigenesis

(2017) Maonan Wang et al.   Journal of Cancer

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ

(2017) Deanna N. Edwards et al.   Science Signaling

ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production

(2017) Etienne Masle-Farquhar et al.   Frontiers in Immunology

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

(2017) Michael Lampa et al.   PLoS One

The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer

(2016) Victoria M. Youngblood et al.   CANCER RESEARCH

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef

(2015) Nicholas J. Matheson et al.   Cell Host & Microbe

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer

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T cell metabolism drives immunity

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ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

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Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Targeting T cell metabolism for therapy

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T cell metabolic fitness in antitumor immunity

(2015) Peter J. Siska et al.   TRENDS IN IMMUNOLOGY

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Environmental and Metabolic Sensors That Control T Cell Biology

(2015) George Ramsay et al.   Frontiers in Immunology

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

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Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Characterization of Cerebral Glutamine Uptake from Blood in the Mouse Brain: Implications for Metabolic Modeling of 13C NMR Data

(2014) Puneet Bagga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer

(2013) Sewha Kim et al.   ENDOCRINE-RELATED CANCER

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

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BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells

(2008) Chun Sung Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

How basal are triple-negative breast cancers?

(2008) François Bertucci et al.   INTERNATIONAL JOURNAL OF CANCER