Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

(2015) G. C. Preston et al.   EMBO JOURNAL

A little sugar goes a long way: The cell biology of O-GlcNAc

(2015) Michelle R. Bond et al.   JOURNAL OF CELL BIOLOGY

IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection

(2015) Amine Boudil et al.   NATURE IMMUNOLOGY

Quantitative phosphoproteomics reveals crosstalk between phosphorylation andO-GlcNAc in the DNA damage response pathway

(2015) Jun Zhong et al.   PROTEOMICS

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

(2013) Wei Liao et al.   IMMUNITY

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Activation of the Transcriptional Function of the NF- B Protein c-Rel by O-GlcNAc Glycosylation

(2013) P. Ramakrishnan et al.   Science Signaling

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Differential requirements for c-Myc in chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice

(2011) J Zhang et al.   LEUKEMIA

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

(2011) Tracey M Gloster et al.   Nature Chemical Biology

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

(2010) Helge C. Dorfmueller et al.   CHEMISTRY & BIOLOGY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

Induction of Glucose Metabolism in Stimulated T Lymphocytes Is Regulated by Mitogen-Activated Protein Kinase Signaling

(2010) Aimee J. Marko et al.   PLoS One

Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis

(2010) Z. Wang et al.   Science Signaling

Selective Requirement for c-Myc at an Early Stage of V 14i NKT Cell Development

(2009) M. P. Mycko et al.   JOURNAL OF IMMUNOLOGY

Intrathymic proliferation wave essential for V 14+ natural killer T cell development depends on c-Myc

(2009) M. Dose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic regulation ofc-Myc proto-oncogene expression during lymphocyte development revealed by aGFP-c-Myc knock-in mouse

(2008) Ching-Yu Huang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY