A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity

Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance

(2019) Yuji Takaoka et al.   CANCER SCIENCE

Inhibition of GLS suppresses proliferation and promotes apoptosis in prostate cancer

(2019) Junfeng Zhang et al.   BIOSCIENCE REPORTS

GLS1 promotes proliferation in hepatocellular carcinoma cells via AKT/GSK3β/CyclinD1 pathway

(2019) Jianbo Xi et al.   EXPERIMENTAL CELL RESEARCH

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

(2019) Ann Lin et al.   Science Translational Medicine

An omics perspective on drug target discovery platforms

(2019) Jussi Paananen et al.   BRIEFINGS IN BIOINFORMATICS

Influence of synthesis methods on the internalization of fluorescent gold nanoparticles into glioblastoma stem-like cells

(2019) Beatriz Giesen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State

(2018) Anneleen Daemen et al.   Cell Metabolism

Targeting glutaminase-mediated glutamine dependence in papillary thyroid cancer

(2018) Yang Yu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis

(2018) Jiaqiu Li et al.   MOLECULAR THERAPY

PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT

(2018) Carmen Mecca et al.   Frontiers in Cellular Neuroscience

Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

(2018) Jae Hyun Kim et al.   Scientific Reports

Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer

(2018) Rong Zhou et al.   CANCER RESEARCH

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

(2018) Samuel K. McBrayer et al.   CELL

Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice

(2018) Gunnar Boysen et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

(2018) Binghua Li et al.   EBioMedicine

Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

(2017) Jianwei Liao et al.   Molecular Cancer

Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer

(2017) Niki Marie Zacharias et al.   Scientific Reports

Metabolic reprogramming during neuronal differentiation

(2016) M Agostini et al.   CELL DEATH AND DIFFERENTIATION

Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways

(2016) U.D. Kahlert et al.   INTERNATIONAL JOURNAL OF CANCER

Clinical aggressiveness of malignant gliomas is linked to augmented metabolism of amino acids

(2016) Eduard H. Panosyan et al.   JOURNAL OF NEURO-ONCOLOGY

Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling

(2016) Lili Guo et al.   TUMOR BIOLOGY

Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells

(2016) Katharina Koch et al.   Oncotarget

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells

(2016) Diancheng Wang et al.   PLoS One

ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres

(2015) Ulf D. Kahlert et al.   BRAIN PATHOLOGY

NVP-BEZ235, a novel dual PI3K–mTOR inhibitor displays anti-glioma activity and reduces chemoresistance to temozolomide in human glioma cells

(2015) Zhiyun Yu et al.   CANCER LETTERS

Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells

(2015) Ulf D. Kahlert et al.   INTERNATIONAL JOURNAL OF CANCER

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

(2015) Kazuhiro Tanaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program

(2015) Xing-gang Mao et al.   Oncotarget

Differences among brain tumor stem cell types and fetal neural stem cells in focal regions of histone modifications and DNA methylation, broad regions of modifications, and bivalent promoters

(2014) Sally Yoo et al.   BMC GENOMICS

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets

(2014) Marie Fève et al.   PLoS One

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 1 Is Essential for the Differentiation, Proliferation, and Survival of Human Neural Progenitor Cells

(2014) Yi Wang et al.   STEM CELLS AND DEVELOPMENT

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

Original article CD133/CD15 defines distinct cell subpopulations with differential in vitro clonogenic activity and stem cell-related gene expression profile in in vitro propagated glioblastoma multiforme-derived cell line with a PNET-like component

(2013) Ulf D. Kahlert et al.   FOLIA NEUROPATHOLOGICA

Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells

(2013) Mercedes Martín-Rufián et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Amino Acids and mTOR Mediate Distinct Metabolic Checkpoints in Mammalian G1 Cell Cycle

(2013) Mahesh Saqcena et al.   PLoS One

The Metabolomic Signature of Malignant Glioma Reflects Accelerated Anabolic Metabolism

(2012) P. Chinnaiyan et al.   CANCER RESEARCH

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression

(2012) Dallas R. Donohoe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Interactions between epigenetics and metabolism in cancers

(2012) Jihye Yun et al.   Frontiers in Oncology

Elevated invasive potential of glioblastoma stem cells

(2011) Lin Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Restricted Spontaneous In Vitro Differentiation and Region-Specific Migration of Long-Term Expanded Fetal Human Neural Precursor Cells After Transplantation Into the Adult Rat Brain

(2009) Jaroslaw Maciaczyk et al.   STEM CELLS AND DEVELOPMENT

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA