Enhanced metabolic activities for ATP production and elevated metabolic flux via pentose phosphate pathway contribute for better CIK cells expansion

Innovative Clinical Perspectives for CIK Cells in Cancer Patients

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Dynamic suspension culture improves ex vivo expansion of cytokine-induced killer cells by upregulating cell activation and glucose consumption rate

(2018) Weiwei Zhang et al.   JOURNAL OF BIOTECHNOLOGY

Influence of the number and interval of treatment cycles on cytokine-induced killer cells and their adjuvant therapeutic effects in advanced non-small-cell lung cancer (NSCLC)

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Cancer Immunotherapy with Cytokine-Induced Killer Cells

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Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy

(2017) Xingchun Gao et al.   Frontiers in Immunology

Glutamine transporters in mammalian cells and their functions in physiology and cancer

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T-cell metabolism governing activation, proliferation and differentiation; a modular view

(2016) Sarah Dimeloe et al.   IMMUNOLOGY

Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions

(2016) Gaspard Cretenet et al.   Scientific Reports

Global cancer statistics, 2012

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Cytokine induced killer cell-based immunotherapies in patients with different stages of renal cell carcinoma

(2015) Xuan Zhao et al.   CANCER LETTERS

T cell metabolism drives immunity

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Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress

(2014) Mineaki Goto et al.   BMC CANCER

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Simplified protocol for clinical-grade tumor-infiltrating lymphocyte manufacturing with use of the Wave bioreactor

(2014) Marco Donia et al.   CYTOTHERAPY

An update on new adoptive immunotherapy strategies for solid tumors with cytokine-induced killer cells

(2014) Clara E Jäkel et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cellular Energy Metabolism in T-Lymphocytes

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Cellular Metabolism on T-Cell Development and Function

(2014) Hui Chen et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Metabolic Reprogramming towards Aerobic Glycolysis Correlates with Greater Proliferative Ability and Resistance to Metabolic Inhibition in CD8 versus CD4 T Cells

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Hyperoxia Decreases Glycolytic Capacity, Glycolytic Reserve and Oxidative Phosphorylation in MLE-12 Cells and Inhibits Complex I and II Function, but Not Complex IV in Isolated Mouse Lung Mitochondria

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Fueling Immunity: Insights into Metabolism and Lymphocyte Function

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CFD analysis of the turbulent flow in baffled shake flasks

(2012) Chao Li et al.   BIOCHEMICAL ENGINEERING JOURNAL

Human lymphocytes cultured in 3-D bioreactors: Influence of configuration on metabolite transport and reactions

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Review of Chinese clinical trials on CIK cell treatment for malignancies

(2012) Xiao-Dong Li et al.   Clinical & Translational Oncology

Simplified Method of the Growth of Human Tumor Infiltrating Lymphocytes in Gas-permeable Flasks to Numbers Needed for Patient Treatment

(2012) Jianjian Jin et al.   JOURNAL OF IMMUNOTHERAPY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Possibility of Adoptive Immunotherapy With Peripheral Blood-derived CD3−CD56+ and CD3+CD56+ Cells for Inducing Antihepatocellular Carcinoma and Antihepatitis C Virus Activity

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Value of large scale expansion of tumor infiltrating lymphocytes in a compartmentalised gas-permeable bag: interests for adoptive immunotherapy

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Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation

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Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes

(2010) R. Dziurla et al.   IMMUNOLOGY LETTERS

Cell Density Plays a Critical Role in Ex Vivo Expansion of T Cells for Adoptive Immunotherapy

(2010) Qiangzhong Ma et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Large-scale bioreactor expansion of tumor-infiltrating lymphocytes

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Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

T-Cell Activation under Hypoxic Conditions Enhances IFN-γ Secretion

(2009) Jessica Roman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion

(2009) Akos A. Gerencser et al.   ANALYTICAL CHEMISTRY

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Cytokine-induced killer cells are terminallydifferentiated activated CD8 cytotoxic T-EMRA lymphocytes

(2009) Marta Franceschetti et al.   EXPERIMENTAL HEMATOLOGY

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

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