Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond

Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer

(2017) Barbara Chiavarina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

(2017) Louise van der Weyden et al.   NATURE

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

(2017) Oliver G McDonald et al.   NATURE GENETICS

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity

(2017) Xenia Geeraerts et al.   Frontiers in Immunology

Tumor slice culture system to assess drug response of primary breast cancer

(2016) Kishan A. T. Naipal et al.   BMC CANCER

L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo

(2016) Yu Cao et al.   BMC CANCER

Hexokinase 2 is a determinant of neuroblastoma metastasis

(2016) Liat Edry Botzer et al.   BRITISH JOURNAL OF CANCER

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling

(2016) Joshua Corbin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

(2016) Oliver D.K. Maddocks et al.   MOLECULAR CELL

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism

(2016) A Cacace et al.   ONCOGENE

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Early and multiple origins of metastatic lineages within primary tumors

(2016) Zi-Ming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DHA blocks TPA-induced cell invasion by inhibiting MMP-9 expression via suppression of the PPAR-γ/NF-κB pathway in MCF-7 cells

(2016) Jin-Ki Hwang et al.   Oncology Letters

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer

(2016) Marybeth Anderson et al.   Oncotarget

Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer

(2016) Wei Lu et al.   Scientific Reports

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

p53 in the DNA-Damage-Repair Process

(2016) Ashley B. Williams et al.   Cold Spring Harbor Perspectives in Medicine

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

(2016) Marie-Julie Nokin et al.   eLife

T Cells and Cancer: How Metabolism Shapes Immunity

(2016) Barbara Molon et al.   Frontiers in Immunology

In vivo cancer metabolism is defined by the nutrient microenvironment

(2016) Ilaria Elia et al.   Translational Cancer Research

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

(2016) Zbynek Heger et al.   PLoS One

Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

(2016) Aritro Nath et al.   Scientific Reports

Raman Spectroscopic Analysis Reveals Abnormal Fatty Acid Composition in Tumor Micro- and Macroenvironments in Human Breast and Rat Mammary Cancer

(2016) Sixian You et al.   Scientific Reports

Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer

(2016) Hugh Colvin et al.   Scientific Reports

Enhanced OXPHOS, glutaminolysis and  -oxidation constitute the metastatic phenotype of melanoma cells

(2015) M. F. Rodrigues et al.   BIOCHEMICAL JOURNAL

Metabolic control of signalling pathways and metabolic auto-regulation

(2015) Doriane Lorendeau et al.   BIOLOGY OF THE CELL

Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential

(2015) K. P. Feeley et al.   CANCER RESEARCH

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

(2015) Valéry L. Payen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetics and Metabolism

(2015) S. T. Keating et al.   CIRCULATION RESEARCH

Metabolism in cancer metastasis

(2015) Georg F. Weber   INTERNATIONAL JOURNAL OF CANCER

Low expression of Bin1, along with high expression of IDO in tumor tissue and draining lymph nodes, are predictors of poor prognosis for esophageal squamous cell cancer patients

(2015) Yunlong Jia et al.   INTERNATIONAL JOURNAL OF CANCER

Knockdown of PKM2 Suppresses Tumor Growth and Invasion in Lung Adenocarcinoma

(2015) Hong Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients

(2015) Gaojie Liu et al.   Journal of Translational Medicine

Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)

(2015) Bethany N. Hannafon et al.   Molecular Cancer

PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

(2015) Guanzhen Yu et al.   Molecular Cancer

Defining the Metabolome: Size, Flux, and Regulation

(2015) Nicola Zamboni et al.   MOLECULAR CELL

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

(2015) Dany Nassar et al.   NATURE MEDICINE

MutantIDHis sufficient to initiate enchondromatosis in mice

(2015) Makoto Hirata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A case control study of sarcosine as an early prostate cancer detection biomarker

(2015) Donna P. Ankerst et al.   BMC Urology

Metabolic Plasticity of Metastatic Breast Cancer Cells: Adaptation to Changes in the Microenvironment

(2015) Rui V. Simões et al.   NEOPLASIA

The Role of Sarcosine Metabolism in Prostate Cancer Progression

(2015) Amjad P Khan et al.   NEOPLASIA

Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment

(2014) Yuko Tanizaki et al.   CANCER SCIENCE

Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

(2014) Nobuaki Shiraki et al.   Cell Metabolism

Blocking Lipid Synthesis Overcomes Tumor Regrowth and Metastasis after Antiangiogenic Therapy Withdrawal

(2014) Nor Eddine Sounni et al.   Cell Metabolism

Implications of differences in expression of sarcosine metabolism-related proteins according to the molecular subtype of breast cancer

(2014) Ja Yoon et al.   Journal of Translational Medicine

Site-specific metabolic phenotypes in metastatic breast cancer

(2014) Hye Min Kim et al.   Journal of Translational Medicine

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Molecular analysis of circulating tumour cells—biology and biomarkers

(2014) Matthew G. Krebs et al.   Nature Reviews Clinical Oncology

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

(2014) L Jiang et al.   ONCOGENE

Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition

(2014) Danielle B. Ulanet et al.   PLoS One

Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies

(2014) O. M. T. Pearce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Evolution: Mathematical Models and Computational Inference

(2014) Niko Beerenwinkel et al.   SYSTEMATIC BIOLOGY

Expression of Indoleamine 2,3-Dioxygenase and Infiltration of FOXP3+ Regulatory T Cells Are Associated with Aggressive Features of Papillary Thyroid Microcarcinoma

(2014) Han Suk Ryu et al.   THYROID

Targeting EMT in cancer: opportunities for pharmacological intervention

(2014) Felicity M. Davis et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Core Needle Biopsy of Breast Cancer Tumors Increases Distant Metastases in a Mouse Model

(2014) Edward Gitau Mathenge et al.   NEOPLASIA

Tumor Cell Dissemination: Emerging Biological Insights from Animal Models and Cancer Patients

(2013) Yibin Kang et al.   CANCER CELL

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis

(2013) W. Liu et al.   CANCER RESEARCH

Hexokinase II in breast carcinoma: A potent prognostic factor associated with hypoxia-inducible factor-1α and Ki-67

(2013) Akiko Sato-Tadano et al.   CANCER SCIENCE

Prospective evaluation of serum sarcosine and risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

(2013) S. Koutros et al.   CARCINOGENESIS

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

In vitro models of the metastatic cascade: from local invasion to extravasation

(2013) S. Bersini et al.   DRUG DISCOVERY TODAY

Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

(2013) Luis Jaime Castro-Vega et al.   HUMAN MOLECULAR GENETICS

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding Metabolic Regulation and Its Influence on Cell Physiology

(2013) Christian M. Metallo et al.   MOLECULAR CELL

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

(2013) Irène Baccelli et al.   NATURE BIOTECHNOLOGY

Roadblocks to translational advances on metastasis research

(2013) Thomas Brabletz et al.   NATURE MEDICINE

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells

(2013) Thomas Green et al.   PROSTATE

Metabolomic signatures of aggressive prostate cancer

(2013) Jonathan E. McDunn et al.   PROSTATE

Identification and validation of dysregulated metabolic pathways in metastatic renal cell carcinoma

(2013) Nicole M. A. White et al.   TUMOR BIOLOGY

Evaluating cell lines as tumour models by comparison of genomic profiles

(2013) Silvia Domcke et al.   Nature Communications

L-Proline Induces a Mesenchymal-like Invasive Program in Embryonic Stem Cells by Remodeling H3K9 and H3K36 Methylation

(2013) Stefania Comes et al.   Stem Cell Reports

Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration

(2012) Christine A. Caneba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

(2012) Masato Ogura et al.   BIOCHEMICAL JOURNAL

Cancer stem cells and EMT in carcinoma

(2012) Adrian Biddle et al.   CANCER AND METASTASIS REVIEWS

Proline Oxidase Promotes Tumor Cell Survival in Hypoxic Tumor Microenvironments

(2012) W. Liu et al.   CANCER RESEARCH

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

(2012) H. Yang et al.   CLINICAL CANCER RESEARCH

Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells

(2012) Cheng-Fu Zhou et al.   IUBMB LIFE

Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)

(2012) Alexandra R. Grassian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer

(2012) Xiwei Wu et al.   Journal of Translational Medicine

Glucose Oxidation Modulates Anoikis and Tumor Metastasis

(2012) S. Kamarajugadda et al.   MOLECULAR AND CELLULAR BIOLOGY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Differential Expression of Metabolic Genes in Tumor and Stromal Components of Primary and Metastatic Loci in Pancreatic Adenocarcinoma

(2012) Nina V. Chaika et al.   PLoS One

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum sarcosine increases the accuracy of prostate cancer detection in patients with total serum PSA less than 4.0 ng/ml

(2012) Giuseppe Lucarelli et al.   PROSTATE

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Signaling in Control of Cell Growth and Metabolism

(2012) P. S. Ward et al.   Cold Spring Harbor Perspectives in Biology

Fully automated solid-phase microextraction–fast gas chromatography–mass spectrometry method using a new ionic liquid column for high-throughput analysis of sarcosine and N-ethylglycine in human urine and urinary sediments

(2011) F. Bianchi et al.   ANALYTICA CHIMICA ACTA

GC/MS-based metabolomic approach to validate the role of urinary sarcosine and target biomarkers for human prostate cancer by microwave-assisted derivatization

(2011) Hao Wu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

High-Throughput Selection, Enumeration, Electrokinetic Manipulation, and Molecular Profiling of Low-Abundance Circulating Tumor Cells Using a Microfluidic System

(2011) Udara Dharmasiri et al.   ANALYTICAL CHEMISTRY

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Mutations in isocitrate dehydrogenase 2 accelerate glioma cell migration via matrix metalloproteinase-2 and 9

(2011) Yuejun Fu et al.   BIOTECHNOLOGY LETTERS

Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

(2011) Kenneth L. Scott et al.   CANCER CELL

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Dissecting the Oncogenic and Tumorigenic Potential of Differentiated Human Induced Pluripotent Stem Cells and Human Embryonic Stem Cells

(2011) Z. Ghosh et al.   CANCER RESEARCH

Phosphoglucose Isomerase/Autocrine Motility Factor Mediates Epithelial-Mesenchymal Transition Regulated by miR-200 in Breast Cancer Cells

(2011) A. Ahmad et al.   CANCER RESEARCH

Reduction of metastasis using a non-volatile buffer

(2011) Arig Ibrahim Hashim et al.   CLINICAL & EXPERIMENTAL METASTASIS

Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification

(2011) Caryl J. Antalis et al.   CLINICAL & EXPERIMENTAL METASTASIS

Indoleamine 2,3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients

(2011) Reinhart Speeckaert et al.   EUROPEAN JOURNAL OF CANCER

HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells

(2011) Giuseppina Comito et al.   FREE RADICAL BIOLOGY AND MEDICINE

Is sarcosine a biomarker for prostate cancer?

(2011) Haleem J. Issaq et al.   JOURNAL OF SEPARATION SCIENCE

The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer

(2011) Yoo Hyun Song et al.   MODERN PATHOLOGY

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production

(2011) P S Ward et al.   ONCOGENE

Serum Methionine Metabolites Are Risk Factors for Metastatic Prostate Cancer Progression

(2011) Sally Stabler et al.   PLoS One

Metabolomic Profiling Reveals a Role for Androgen in Activating Amino Acid Metabolism and Methylation in Prostate Cancer Cells

(2011) Nagireddy Putluri et al.   PLoS One

Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)- -TrCP, sequentially regulate glycolysis during the cell cycle

(2011) S. Tudzarova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Discriminating Isogenic Cancer Cells and Identifying Altered Unsaturated Fatty Acid Content as Associated with Metastasis Status, Using K-Means Clustering and Partial Least Squares-Discriminant Analysis of Raman Maps

(2010) Martin Hedegaard et al.   ANALYTICAL CHEMISTRY

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

(2010) Michael Dewaele et al.   Autophagy

Fish oil prevents breast cancer cell metastasis to bone

(2010) Chandi Charan Mandal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

(2010) Sirkku Pollari et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Indoleamine 2,3-Dioxygenase

(2010) Hatem Soliman et al.   CANCER JOURNAL

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in Urine After Digital Rectal Examination Fails as a Marker in Prostate Cancer Detection and Identification of Aggressive Tumours. Eur Urol 2010;58:12–8

(2010) Amitha K Hewavitharana   EUROPEAN UROLOGY

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Metabolism strikes back: metabolic flux regulates cell signaling

(2010) C. M. Metallo et al.   GENES & DEVELOPMENT

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Sarcosine in Prostate Cancer Tissue is Not a Differential Metabolite for Prostate Cancer Aggressiveness and Biochemical Progression

(2010) Florian Jentzmik et al.   JOURNAL OF UROLOGY

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

(2010) Kathryn E. Wellen et al.   MOLECULAR CELL

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Docosahexaenoic Acid Induces Apoptosis in MCF-7 Cells In Vitro and In Vivo via Reactive Oxygen Species Formation and Caspase 8 Activation

(2010) Ki Sung Kang et al.   PLoS One

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

(2010) K. A. Janeway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multiplex model of combining gene-based, protein-based, and metabolite-based with positive and negative markers in urine for the early diagnosis of prostate cancer

(2010) Da-Long Cao et al.   PROSTATE

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer

(2009) Aaron S Mansfield et al.   BMC CANCER

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Gene expression profiles and breast cancer metastasis: a genetic perspective

(2009) Kent W. Hunter et al.   CLINICAL & EXPERIMENTAL METASTASIS

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Upregulation of glycolytic enzymes in proteins secreted from human colon cancer cells with 5-fluorouracil resistance

(2009) Young-Kyoung Shin et al.   ELECTROPHORESIS

Phosphoglucose isomerase enhances colorectal cancer metastasis

(2009) Tsutsumi   INTERNATIONAL JOURNAL OF ONCOLOGY

IDO Mediates TLR9-Driven Protection from Experimental Autoimmune Diabetes

(2009) F. Fallarino et al.   JOURNAL OF IMMUNOLOGY

Indoleamine 2,3-Dioxygenase+ Cells Correspond to the BDCA2+ Plasmacytoid Dendritic Cells in Human Melanoma Sentinel Nodes

(2009) Gianni Gerlini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tumour seeding in a case of malignant melanoma due to fine needle aspiration of a lymph node

(2009) A.J. Robinson et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

(2009) Arun Sreekumar et al.   NATURE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases

(2009) Derek M. Dykxhoorn et al.   PLoS One

Expression Patterns in Mouse Embryos of Neuroleukin/Glucose-6-Phosphate Isomerase and Autocrine Motility Factor Receptor

(2008) A. Repiso et al.   ANATOMIA HISTOLOGIA EMBRYOLOGIA

Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases

(2008) Monica Zerilli et al.   CANCER

Molecular mechanisms of metastasis

(2008) Georg F. Weber   CANCER LETTERS

Epithelial-Mesenchymal Transition Induced by Growth Suppressor p12CDK2-AP1 Promotes Tumor Cell Local Invasion but Suppresses Distant Colony Growth

(2008) T. Tsuji et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival

(2008) E Giannoni et al.   CELL DEATH AND DIFFERENTIATION

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metastasis is promoted by a bioenergetic switch: New targets for progressive renal cell cancer

(2008) Sigrun Langbein et al.   INTERNATIONAL JOURNAL OF CANCER

Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells

(2008) Xiaojun Xu et al.   INTERNATIONAL JOURNAL OF CANCER

Expanding chemical biology of 2-oxoglutarate oxygenases

(2008) Christoph Loenarz et al.   Nature Chemical Biology

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

Metastasis: a therapeutic target for cancer

(2008) Patricia S Steeg et al.   Nature clinical practice. Oncology