Impact of l-Arginine Metabolism on Immune Response and Anticancer Immunotherapy

COX2/mPGES1/PGE2pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells

(2017) Victor Prima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting iNOS to increase efficacy of immunotherapies

(2017) Suhendan Ekmekcioglu et al.   Human Vaccines & Immunotherapeutics

Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma

(2017) Alexandre Reuben et al.   npj Genomic Medicine

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma

(2016) S. Ekmekcioglu et al.   CLINICAL CANCER RESEARCH

Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation

(2015) Muly Tham et al.   Oncotarget

l-Arginine and its metabolites in kidney and cardiovascular disease

(2014) Ada Popolo et al.   AMINO ACIDS

L-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

(2014) M. Fletcher et al.   CANCER RESEARCH

Developing an Irreversible Inhibitor of Human DDAH-1, an Enzyme Upregulated in Melanoma

(2014) Yun Wang et al.   ChemMedChem

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression

(2014) J. L. Heinecke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Pathways: Inflammation-Associated Nitric-Oxide Production as a Cancer-Supporting Redox Mechanism and a Potential Therapeutic Target

(2013) E. A. Grimm et al.   CLINICAL CANCER RESEARCH

Nitric oxide-based protein modification: formation and site-specificity of protein S-nitrosylation

(2013) Izabella Kovacs et al.   Frontiers in Plant Science

Altered functions of natural killer cells in response to L-Arginine availability

(2012) Bruno Lamas et al.   CELLULAR IMMUNOLOGY

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

The role of melanoma tumor-derived nitric oxide in the tumor inflammatory microenvironment: Its impact on the chemokine expression profile, including suppression of CXCL10

(2011) Keiji Tanese et al.   INTERNATIONAL JOURNAL OF CANCER

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Protein tyrosine nitration in cellular signal transduction pathways

(2010) Vasily A. Yakovlev et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via L-Arginine Metabolism

(2009) L. A. Norian et al.   CANCER RESEARCH

Prognostic significance of tumor iNOS and COX-2 in stage III malignant cutaneous melanoma

(2008) C. Christian Johansson et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Arginine Deprivation as a Targeted Therapy for Cancer

(2008) L. Feun et al.   CURRENT PHARMACEUTICAL DESIGN

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE