Kynurenines in the CNS: recent advances and new questions

Mitochondrial Disturbances, Tryptophan Metabolites and Neurodegeneration: Medicinal Chemistry Aspects

(2012) L. Szalardy et al.   CURRENT MEDICINAL CHEMISTRY

Manipulating Kynurenic Acid Levels in the Brain – On the Edge Between Neuroprotection and Cognitive Dysfunction

(2012) Levente Szalardy et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

(2012) Ute F. Röhrig et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel kynurenic acid analog (SZR104) inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study

(2012) Ildikó Demeter et al.   JOURNAL OF NEURAL TRANSMISSION

Pre-specified subgroup analyses of a placebo-controlled phase III trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis

(2012) Aaron E Miller et al.   Multiple Sclerosis Journal

Long-term follow-up of a phase 2 study of oral teriflunomide in relapsing multiple sclerosis: safety and efficacy results up to 8.5 years

(2012) Christian Confavreux et al.   Multiple Sclerosis Journal

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Teriflunomide added to interferon-  in relapsing multiple sclerosis: A randomized phase II trial

(2012) M. S. Freedman et al.   NEUROLOGY

Placebo-Controlled Trial of Oral Laquinimod for Multiple Sclerosis

(2012) Giancarlo Comi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors

(2011) David Meininger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen

(2011) Jason R. Smith et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

(2011) Susanna Campesan et al.   CURRENT BIOLOGY

Kynurenine Metabolites and Migraine: Experimental Studies and Therapeutic Perspectives

(2011) Annamaria Fejes et al.   Current Neuropharmacology

Meta-analysis of genome-wide association for migraine in six population-based European cohorts

(2011) Lannie Ligthart et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia

(2011) Levente Gellért et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kynurenines and headache

(2011) Árpád Párdutz et al.   JOURNAL OF NEURAL TRANSMISSION

The kynurenine system and immunoregulation

(2011) Yvette Mándi et al.   JOURNAL OF NEURAL TRANSMISSION

The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment

(2011) Allison B Gold et al.   Journal of Neuroinflammation

Age Dependency of Inhibition of  7 Nicotinic Receptors and Tonically Active N-Methyl-D-aspartate Receptors by Endogenously Produced Kynurenic Acid in the Brain

(2011) M. Alkondon et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

(2011) Daniel I Chasman et al.   NATURE GENETICS

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils

(2011) Zoltán Tiszlavicz et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis

(2011) Paul O'Connor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vitamin D, invariant natural killer T-cells and experimental autoimmune disease

(2011) Margherita T. Cantorna et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Synthesis and Pharmacological Evaluation of Some 4-Oxo-quinoline-2-carboxylic Acid Derivatives as Anti-inflammatory and Analgesic Agents

(2010) Orazio Mazzoni et al.   ARCHIV DER PHARMAZIE

Protective effect of systemic l-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25–35) in rat hippocampus

(2010) Paul Carrillo-Mora et al.   BEHAVIOURAL BRAIN RESEARCH

Expression of functional GPR35 in human iNKT cells

(2010) Silvia Fallarini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

(2010) Eduard Dolušić et al.   BIOORGANIC & MEDICINAL CHEMISTRY

S-Benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase

(2010) Kenji Matsuno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

(2010) X. Liu et al.   BLOOD

Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: Pharmacophore modeling and molecular docking studies

(2010) Shalini John et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity

(2010) Jietang Mai   Frontiers in Bioscience-Landmark

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Rational Design of Indoleamine 2,3-Dioxygenase Inhibitors

(2010) Ute F. Röhrig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington’s disease

(2010) Dénes Zádori et al.   JOURNAL OF NEURAL TRANSMISSION

Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis

(2010) Yiquan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Hydroxyamidine Inhibitors of Indoleamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors

(2010) H. K. Koblish et al.   MOLECULAR CANCER THERAPEUTICS

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1

(2010) Verneri Anttila et al.   NATURE GENETICS

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

(2010) Yutang Wang et al.   NATURE MEDICINE

Protective effect of l-kynurenine and probenecid on 6-hydroxydopamine-induced striatal toxicity in rats: Implications of modulating kynurenate as a protective strategy

(2010) Daniela Silva-Adaya et al.   NEUROTOXICOLOGY AND TERATOLOGY

Is Toxoplasma gondii a Causal Agent in Migraine?

(2009) Emel Koseoglu et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

The Selenazal Drug Ebselen Potently Inhibits Indoleamine 2,3-Dioxygenase by Targeting Enzyme Cysteine Residues

(2009) Andrew C. Terentis et al.   BIOCHEMISTRY

Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives

(2009) F. Fulop et al.   CURRENT MEDICINAL CHEMISTRY

Kynurenate Derivative Attenuates the Nitroglycerin-Induced CamKIIα and CGRP Expression Changes

(2009) Enikő Vámos et al.   HEADACHE

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

(2009) Eddy W. Yue et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel kynurenic acid analogue: a comparison with kynurenic acid. An in vitro electrophysiological study

(2009) Máté Marosi et al.   JOURNAL OF NEURAL TRANSMISSION

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

N-Methyl-d-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat

(2009) g. varga et al.   NEUROGASTROENTEROLOGY AND MOTILITY

l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus

(2009) Enikő Vámos et al.   NEUROPHARMACOLOGY

The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis

(2009) Yiquan Chen et al.   NEUROTOXICITY RESEARCH

Plectosphaeroic Acids A, B, and C, Indoleamine 2,3-Dioxygenase Inhibitors Produced in Culture by a Marine Isolate of the FungusPlectosphaerella cucumerina

(2009) Gavin Carr et al.   ORGANIC LETTERS

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

The pentylenetetrazole-induced activity in the hippocampus can be inhibited by the conversion of l-kynurenine to kynurenic acid: An in vitro study

(2008) Eva Rozsa et al.   BRAIN RESEARCH BULLETIN

IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

(2008) Stefan Löb et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Kynurenic acid attenuates MPP+-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway

(2008) Do Yeon Lee et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain

(2008) Xiao-Xiu Qu et al.   EXPERIMENTAL NEUROLOGY

Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage

(2008) Jasminka Mizdrak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Indoleamine 2,3-Dioxygenase Inhibitory Analogues of the Sponge Alkaloid Exiguamine A

(2008) Gavin Carr et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure Based Development of Phenylimidazole-Derived Inhibitors of Indoleamine 2,3-Dioxygenase

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of theHomo sapiensKynureninase-3-Hydroxyhippuric Acid Inhibitor Complex: Insights into the Molecular Basis Of Kynureninase Substrate Specificity†

(2008) Santiago Lima et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Janus-face kynurenic acid

(2008) Éva Rózsa et al.   JOURNAL OF NEURAL TRANSMISSION

Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) G Comi et al.   LANCET

Neuroprotection achieved in the ischaemic rat cortex with l-kynurenine sulphate

(2008) Hermina Robotka et al.   LIFE SCIENCES

Biomimetic synthesis of the IDO inhibitors exiguamine A and B

(2008) Matthew Volgraf et al.   Nature Chemical Biology

Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus

(2008) Katalin Sas et al.   NEUROBIOLOGY OF DISEASE

The kynurenate analog SZR-72 prevents the nitroglycerol-induced increase of c-fos immunoreactivity in the rat caudal trigeminal nucleus: Comparative studies of the effects of SZR-72 and kynurenic acid

(2008) E. Knyihar-Csillik et al.   NEUROSCIENCE RESEARCH

Th17 Cells and Autoimmune Encephalomyelitis (EAE/MS)

(2008) Toshimasa Aranami et al.   ALLERGOLOGY INTERNATIONAL

Effects of Mitochondria and O-Methoxybenzoylalanine on 3-Hydroxyanthranilic Acid Dioxygenase Activity and Quinolinic Acid Synthesis

(2003) Alberto Chiarugi et al.   JOURNAL OF NEUROCHEMISTRY