Amino acid metabolism in hematologic malignancies and the era of targeted therapy

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

(2019) Courtney L. Jones et al.   BLOOD

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy

(2019) Mark A. Gregory et al.   CLINICAL CANCER RESEARCH

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glutaminolysis is a metabolic dependency in FLT3ITDacute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

(2018) Paolo Gallipoli et al.   BLOOD

Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia

(2018) Mark A. Gregory et al.   EXPERIMENTAL HEMATOLOGY

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2018) Courtney L. Jones et al.   CANCER CELL

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

(2018) Francis Mussai et al.   INTERNATIONAL JOURNAL OF CANCER

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia

(2018) Peter van Galen et al.   Cell Reports

Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1–Deficient Thoracic Cancers

(2017) Emma Beddowes et al.   JOURNAL OF CLINICAL ONCOLOGY

Drug-induced amino acid deprivation as strategy for cancer therapy

(2017) Marcus Kwong Lam Fung et al.   Journal of Hematology & Oncology

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Amino acid deprivation using enzymes as a targeted therapy for cancer and viral infections

(2016) H. S. Fernandes et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation

(2016) Y. Taya et al.   SCIENCE

A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas

(2016) Gregory R Bean et al.   Cell Death & Disease

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

(2016) Polina Matre et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target

(2015) F. Mussai et al.   BLOOD

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

(2015) N. Jacque et al.   BLOOD

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo

(2015) F. Miraki-Moud et al.   BLOOD

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

PEGylation and pharmacological characterization of a potential anti-tumor drug, an engineered arginine deiminase originated from Pseudomonas plecoglossicida

(2015) Long Zhang et al.   CANCER LETTERS

Glutaminase activity determines cytotoxicity of l-asparaginases on most leukemia cell lines

(2015) Jean Hugues Parmentier et al.   LEUKEMIA RESEARCH

Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines

(2015) Wei-Wen Chien et al.   Scientific Reports

The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells

(2014) W. K. Chan et al.   BLOOD

Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling

(2014) Jiangbo Liu et al.   BMC CANCER

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy against Brain Tumors

(2014) Eduard H. Panosyan et al.   MOLECULAR CANCER RESEARCH

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

(2013) F. Mussai et al.   BLOOD

Asparaginase unveils glutamine-addicted AML

(2013) I. Samudio et al.   BLOOD

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Adipocytes Cause Leukemia Cell Resistance to L-Asparaginase via Release of Glutamine

(2013) E. A. Ehsanipour et al.   CANCER RESEARCH

Loss of p53 and altered miR15-a/16-1→MCL-1 pathway in CLL: insights from TCL1-Tg:p53 −/− mouse model and primary human leukemia cells

(2013) J Liu et al.   LEUKEMIA

Nitric oxide and cancer: a review

(2013) Sheetal Korde Choudhari et al.   World Journal of Surgical Oncology

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

(2012) W.-B. Tsai et al.   CANCER RESEARCH

Erwinia asparaginase in pediatric acute lymphoblastic leukemia

(2012) Wanda Salzer et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

(2012) Patrick A. Ott et al.   INVESTIGATIONAL NEW DRUGS

Withdrawal of Essential Amino Acids Increases Autophagy by a Pathway Involving Ca2+/Calmodulin-dependent Kinase Kinase-β (CaMKK-β)

(2012) Ghita Ghislat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Polyethylene Glycol-conjugated L-asparaginase Versus Native L-asparaginase in Combination With Standard Agents for Children With Acute Lymphoblastic Leukemia in Second Bone Marrow Relapse

(2011) Joanne Kurtzberg et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

(2011) P. T. Mungai et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Purification and characterization of glutaminase-free l-asparaginase from Pectobacterium carotovorum MTCC 1428

(2010) Sanjay Kumar et al.   BIORESOURCE TECHNOLOGY

Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity

(2010) M. N. Offman et al.   BLOOD

Pegylated arginase I: a potential therapeutic approach in T-ALL

(2010) C. P. Hernandez et al.   BLOOD

A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

(2010) T-S Yang et al.   BRITISH JOURNAL OF CANCER

Phase II Study of Pegylated Arginine Deiminase for Nonresectable and Metastatic Hepatocellular Carcinoma

(2010) Evan S. Glazer et al.   JOURNAL OF CLINICAL ONCOLOGY

Vincristine but not imatinib could suppress mesenchymal niche's support to lymphoid leukemic cells

(2010) Kwong-Lam Fung et al.   LEUKEMIA & LYMPHOMA

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Arginine Deprivation as a Targeted Therapy for Cancer

(2008) L. Feun et al.   CURRENT PHARMACEUTICAL DESIGN

Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study

(2008) I M Appel et al.   LEUKEMIA