Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Plasticity of myeloid-derived suppressor cells in cancer

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Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

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Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Cancer immunotherapy using checkpoint blockade

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Metabolic Kinases Moonlighting as Protein Kinases

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Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

(2018) Benjamin Knier et al.   NATURE IMMUNOLOGY

Circulating CD14+ HLA-DR−/low myeloid-derived suppressor cells predicted early recurrence of hepatocellular carcinoma after surgery

(2017) Xing-Hui Gao et al.   HEPATOLOGY RESEARCH

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

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Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Myeloid-derived suppressor cells correlate with patient outcomes in hepatic arterial infusion chemotherapy for hepatocellular carcinoma

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L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

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Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans

(2016) Owen R. Kinsky et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

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Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

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Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease

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Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

Immunometabolism governs dendritic cell and macrophage function

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Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

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Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

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Methylglyoxal, the dark side of glycolysis

(2015) Igor Allaman et al.   Frontiers in Neuroscience

A Mass Spectrometric-Derived Cell Surface Protein Atlas

(2015) Damaris Bausch-Fluck et al.   PLoS One

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Regulatory T cells in cancer immunotherapy

(2014) Hiroyoshi Nishikawa et al.   CURRENT OPINION IN IMMUNOLOGY

Accurate Determination of Reference Materials and Natural Isolates by Means of Quantitative 1H NMR Spectroscopy

(2014) Oliver Frank et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells

(2014) F. Qiu et al.   Science Signaling

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Increase in CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis

(2013) Fumitaka Arihara et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion

(2013) Bastian Höchst et al.   JOURNAL OF HEPATOLOGY

A “Turn-On” Fluorescent Sensor for Methylglyoxal

(2013) Tina Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

(2013) Li-Rung Huang et al.   NATURE IMMUNOLOGY

Genetic Characteristics of the Human Hepatic Stellate Cell Line LX-2

(2013) Ralf Weiskirchen et al.   PLoS One

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

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Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

The Dicarbonyl Proteome

(2008) Naila Rabbani et al.   Annals of the New York Academy of Sciences

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A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY