The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics

Peroxide-cleavable linkers for antibody–drug conjugates

(2023) Nicola Ashman et al.   CHEMICAL COMMUNICATIONS

pH-triggered cancer-targeting polymers: From extracellular accumulation to intracellular release

(2023) Rizwan Ullah Khan et al.   Nano Research

Antibody–drug conjugates and bispecific antibodies targeting cancers: applications of click chemistry

(2023) Yeji Hong et al.   ARCHIVES OF PHARMACAL RESEARCH

Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy

(2023) Wei Du et al.   BIOMATERIALS

Antibody–Biopolymer Conjugates in Oncology: A Review

(2023) Vivek P. Chavda et al.   MOLECULES

Evolving Treatment Landscape of HER2-mutant Non-Small Cell Lung Cancer: Trastuzumab Deruxtecan and Beyond

(2023) Ioannis A. Vathiotis et al.   Cancers

Smart Nanomedicine to Enable Crossing Blood–Brain Barrier Delivery of Checkpoint Blockade Antibody for Immunotherapy of Glioma

(2022) Hairong Wang et al.   ACS Nano

Intracellular Co-delivery of native antibody and siRNA for combination therapy by using biodegradable silica nanocapsules

(2022) Peiyan Yuan et al.   BIOMATERIALS

An update on cell-penetrating peptides with intracellular organelle targeting

(2022) Carmine Pasquale Cerrato et al.   Expert Opinion on Drug Delivery

IgNAR antibody: Structural features, diversity and applications

(2022) Zunera Khalid et al.   FISH & SHELLFISH IMMUNOLOGY

Fabrication of Fragment Antibody–Enzyme Complex as a Sensing Element for Immunosensing

(2022) Miho Oda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning

(2022) David Prihoda et al.   mAbs

Antibodies to watch in 2022

(2022) Hélène Kaplon et al.   mAbs

Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells

(2022) Ole Tietz et al.   Nature Chemistry

Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics

(2022) Yue Sun et al.   Nature Chemistry

Molecular Spatiomics by Proximity Labeling

(2022) Myeong-Gyun Kang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Site-Specific Chemoenzymatic Conjugation of High-Affinity M6P Glycan Ligands to Antibodies for Targeted Protein Degradation

(2022) Xiao Zhang et al.   ACS Chemical Biology

Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins

(2022) Josef A. Gramespacher et al.   ACS Chemical Biology

Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and Stemness

(2022) Ada Nowosad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An antibody Fc engineered for conditional antibody-dependent cellular cytotoxicity at the low tumor microenvironment pH

(2022) Yutong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

μMap-Red: Proximity Labeling by Red Light Photocatalysis

(2022) Benito F. Buksh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single Mutation on Trastuzumab Modulates the Stability of Antibody–Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry

(2022) Xhenti Ferhati et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection of cell–cell interactions via photocatalytic cell tagging

(2022) Rob C. Oslund et al.   Nature Chemical Biology

Top companies and drugs by sales in 2021

(2022) Lisa Urquhart   NATURE REVIEWS DRUG DISCOVERY

COVID-19 therapeutics: Challenges and directions for the future

(2022) Philip C. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibodies in the intracellular domain

(2022) William A. McEwan   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

(2022) Ranjith Kumar Kankala et al.   JOURNAL OF NANOBIOTECHNOLOGY

Structure-Property Relationship for Different Mesoporous Silica Nanoparticles and its Drug Delivery Applications: A Review

(2022) Parya Kazemzadeh et al.   Frontiers in Chemistry

Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging

(2022) Ziqi Liu et al.   Chem

Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

(2022) Yamin Li et al.   Acta Pharmaceutica Sinica B

Radiolabeled Antibodies for Cancer Imaging and Therapy

(2022) Sagun Parakh et al.   Cancers

Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System

(2022) Ildikó Szabó et al.   Pharmaceutics

Endocytosis‐Independent and Cancer‐Selective Cytosolic Protein Delivery via Reversible Tagging with LAT1 substrate

(2022) Ziyin Zhao et al.   ADVANCED MATERIALS

A Traceless Site‐Specific Conjugation on Native Antibodies Enables Efficient One‐Step Payload Assembly

(2022) Yue Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Approaches and materials for endocytosis-independent intracellular delivery of proteins

(2022) Nanxi Chen et al.   BIOMATERIALS

Designing antibodies as therapeutics

(2022) Paul J. Carter et al.   CELL

Chemical and Enzymatic Methods for Post-Translational Protein–Protein Conjugation

(2022) Ross J. Taylor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Room-Temperature Grafting from Synthesis of Protein–Polydisulfide Conjugates via Aggregation-Induced Polymerization

(2022) Jianhua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic insights into the rational design of masked antibodies

(2022) Carolina T. Orozco et al.   mAbs

Avidity in antibody effector functions and biotherapeutic drug design

(2022) Simone C. Oostindie et al.   NATURE REVIEWS DRUG DISCOVERY

Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance

(2022) Xinlei Zhuang et al.   Nature Communications

Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes

(2022) Dingdong Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody targeting of E3 ubiquitin ligases for receptor degradation

(2022) Hadir Marei et al.   NATURE

Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins

(2022) Katarina Pance et al.   NATURE BIOTECHNOLOGY

Targeted activation in localized protein environments via deep red photoredox catalysis

(2022) Nicholas Eng Soon Tay et al.   Nature Chemistry

Ozoralizumab: First Approval

(2022) Susan J. Keam   DRUGS

Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial

(2022) Sara A Hurvitz et al.   LANCET

Monoclonal antibody therapeutics for infectious diseases: Beyond normal human immunoglobulin

(2022) Ryota Otsubo et al.   PHARMACOLOGY & THERAPEUTICS

Proximity ligation assay: an ultrasensitive method for protein quantification and its applications in pathogen detection

(2021) Pengzhi Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Design of polymers for intracellular protein and peptide delivery

(2021) Yiyun Cheng   CHINESE JOURNAL OF CHEMISTRY

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

(2021) Adam D. Cotton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deciphering molecular interactions by proximity labeling

(2021) Wei Qin et al.   NATURE METHODS

Nanomaterials for T-cell cancer immunotherapy

(2021) Ningqiang Gong et al.   Nature Nanotechnology

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

(2021) Paul-Albert Koenig et al.   SCIENCE

Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation

(2021) Harini Narayanan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues

(2021) Marcus P Kelly et al.   Journal for ImmunoTherapy of Cancer

The renaissance of chemically generated bispecific antibodies

(2021) Peter Szijj et al.   Nature Reviews Chemistry

Metal–Organic Frameworks for Drug Delivery: A Design Perspective

(2021) Harrison D. Lawson et al.   ACS Applied Materials & Interfaces

Recent Advances in Polymeric Nanoparticles for Enhanced Fluorescence and Photoacoustic Imaging

(2021) Sing Yee Ong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Achievements and Challenges in Prolonging the Serum Half-Lives of Therapeutic IgG Antibodies Through Fc Engineering

(2021) Sanghwan Ko et al.   BIODRUGS

Design of Polymeric Carriers for Intracellular Peptide Delivery in Oncology Applications

(2021) Shixian Lv et al.   CHEMICAL REVIEWS

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties

(2021) Peter S. Dragovich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unlocking the potential of antibody–drug conjugates for cancer therapy

(2021) Joshua Z. Drago et al.   Nature Reviews Clinical Oncology

Target-induced clustering activates Trim-Away of pathogens and proteins

(2021) Jingwei Zeng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges

(2021) Weisen Zhang et al.   Advanced Science

Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins

(2021) Yaxian Zhou et al.   ACS Central Science

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis

(2021) Capucine L. Grandjean et al.   Science Advances

Antibody-Oligonucleotide Conjugates: A Twist to Antibody-Drug Conjugates

(2021) Julien Dugal-Tessier et al.   Journal of Clinical Medicine

Nanogel‐Facilitated Protein Intracellular Specific Degradation through Trim‐Away

(2021) Binglin Sui et al.   ADVANCED FUNCTIONAL MATERIALS

Oligonucleotide Bioconjugation with Bifunctional Palladium Reagents

(2021) Muhammad Jbara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Approval success rates of drug candidates based on target, action, modality, application, and their combinations

(2021) Shingo Yamaguchi et al.   CTS-Clinical and Translational Science

Progress in tumour-targeted drug delivery based on cell-penetrating peptides

(2021) Xinru Kong et al.   JOURNAL OF DRUG TARGETING

Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery

(2021) Junping Pei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen

(2021) Keita Nakane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

(2021) Green Ahn et al.   Nature Chemical Biology

FDA approves 100th monoclonal antibody product

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Selective and noncovalent targeting of RAS mutants for inhibition and degradation

(2021) Kai Wen Teng et al.   Nature Communications

Biomaterials‐Based Delivery of Therapeutic Antibodies for Cancer Therapy

(2021) Qian‐Ni Ye et al.   Advanced Healthcare Materials

Metal–Organic Framework-Based Composites for Protein Delivery and Therapeutics

(2021) Yan Guo et al.   ACS Biomaterials-Science & Engineering

Bispecific Antibodies: From Research to Clinical Application

(2021) Jiabing Ma et al.   Frontiers in Immunology

The Masking Game: Design of Activatable Antibodies and Mimetics for Selective Therapeutics and Cell Control

(2021) Roberta Lucchi et al.   ACS Central Science

Unleashing the Power of Bond Cleavage Chemistry in Living Systems

(2021) Jie Wang et al.   ACS Central Science

Antibody‒drug conjugates: Recent advances in linker chemistry

(2021) Zheng Su et al.   Acta Pharmaceutica Sinica B

Interrogating biological systems using visible-light-powered catalysis

(2021) Keun Ah Ryu et al.   Nature Reviews Chemistry

The Chemistry Behind ADCs

(2021) Vesela Kostova et al.   Pharmaceuticals

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

(2021) Bing-Mae Chen et al.   ACS Nano

Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

(2021) Rumiana Tenchov et al.   ACS Nano

Mito‐Bomb: Targeting Mitochondria for Cancer Therapy

(2021) Xiaolu Guo et al.   ADVANCED MATERIALS

A Wireframe DNA Cube: Antibody Conjugate for Targeted Delivery of Multiple Copies of Monomethyl Auristatin E

(2021) Anders Märcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides

(2021) Takahiro Iwata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐labelled Oligonucleotides

(2021) Juraj Konč et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1,3‐Diketone‐Modified Nucleotides and DNA for Cross‐Linking with Arginine‐Containing Peptides and Proteins

(2021) Denise‐Liu' Leone et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Affinity-Based Methods for Site-Specific Conjugation of Antibodies

(2021) Emma von Witting et al.   BIOCONJUGATE CHEMISTRY

Types of nuclear localization signals and mechanisms of protein import into the nucleus

(2021) Juane Lu et al.   Cell Communication and Signaling

Cell‐Penetrating Mitochondrion‐Targeting Ligands for the Universal Delivery of Small Molecules, Proteins and Nanomaterials

(2021) Qicai Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Strategies for targeting undruggable targets

(2021) Gong Zhang et al.   Expert Opinion on Drug Discovery

Principles and Current Clinical Landscape of Multispecific Antibodies against Cancer

(2021) Mariam Elshiaty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploiting Protein N-Terminus for Site-Specific Bioconjugation

(2021) Lucia De Rosa et al.   MOLECULES

Cytosolic Protein Delivery for Intracellular Antigen Targeting Using Supercharged Polypeptide Delivery Platform

(2021) Qun Wang et al.   NANO LETTERS

An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin

(2021) Elena Rosini et al.   Nanomedicine-Nanotechnology Biology and Medicine

Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy

(2021) Rachel Yamin et al.   NATURE

Switching on prodrugs using radiotherapy

(2021) Jin Geng et al.   Nature Chemistry

Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool

(2021) Muhammad Imran Sajid et al.   PEPTIDES

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

(2021) Chisato M. Yamazaki et al.   Nature Communications

Protease-Activation of Fc-Masked Therapeutic Antibodies to Alleviate Off-Tumor Cytotoxicity

(2021) Adrian Elter et al.   Frontiers in Immunology

Rational Design of Poly(disulfide)s as a Universal Platform for Delivery of CRISPR-Cas9 Machineries toward Therapeutic Genome Editing

(2021) Jiajing Guo et al.   ACS Central Science

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Switchable immune modulator for tumor-specific activation of anticancer immunity

(2021) Yu Zhao et al.   Science Advances

Bispecific Antibodies: A Smart Arsenal for Cancer Immunotherapies

(2021) Gihoon You et al.   Vaccines

Recent advances in protein modifications techniques for the targeting N‐terminal cysteine

(2021) Nicholas Asiimwe et al.   Peptide Science

Strategies and Applications of Antigen-Binding Fragment (Fab) Production in Escherichia coli

(2021) Hui Chen et al.   Pharmaceutical Fronts

“Clickable” ZIF-8 for Cell-Type-Specific Delivery of Functional Proteins

(2021) Jian Liu et al.   ACS Chemical Biology

Cell-penetrating peptides in protein mimicry and cancer therapeutics

(2021) Matjaž Zorko et al.   ADVANCED DRUG DELIVERY REVIEWS

Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway

(2021) Katelyn Cassidy et al.   BIOCHEMISTRY

Genetic and Covalent Protein Modification Strategies to Facilitate Intracellular Delivery

(2021) Justin M. Horn et al.   BIOMACROMOLECULES

In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s

(2021) Yulong Kong et al.   CHEMICAL COMMUNICATIONS

Cell-penetrating poly(disulfide)-based nanoquenchers (qCPDs) for self-monitoring of intracellular gene delivery

(2021) Wenjie Lang et al.   CHEMICAL COMMUNICATIONS

Engineered Cell‐Penetrating Peptides for Mitochondrion‐Targeted Drug Delivery in Cancer Therapy

(2021) Qicai Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Factors influencing the choice of monoclonal antibodies for antibody–drug conjugates

(2021) Md. Mahbub Hasan et al.   DRUG DISCOVERY TODAY

Agonist antibody discovery: Experimental, computational, and rational engineering approaches

(2021) John S. Schardt et al.   DRUG DISCOVERY TODAY

Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations

(2021) Małgorzata Kus-Liśkiewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeted Fluorogenic Cyanine Carbamates Enable In Vivo Analysis of Antibody–Drug Conjugate Linker Chemistry

(2021) Syed Muhammad Usama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation

(2021) Heng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody–oligonucleotide conjugates enter the clinic

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease

(2021) Eva Nordström et al.   NEUROBIOLOGY OF DISEASE

Fc-engineered antibodies with immune effector functions completely abolished

(2021) Ian Wilkinson et al.   PLoS One

Engineered antibody fusion proteins for targeted disease therapy

(2021) Aliyah B. Silver et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A chemical tool for blue light-inducible proximity photo-crosslinking in live cells

(2021) Pratyush Kumar Mishra et al.   Chemical Science

Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks

(2021) Maik Müller et al.   Nature Communications

Vaccinal antibodies: Fc antibody engineering to improve the antiviral antibody response and induce vaccine-like effects

(2021) Dhuha H Nawab   Human Vaccines & Immunotherapeutics

Organelle-level precision with next-generation targeting technologies

(2021) Anand Saminathan et al.   Nature Reviews Materials

Current and Emerging Strategies for Enhancing Antibody Delivery to the Brain

(2021) Rinie Bajracharya et al.   Pharmaceutics

A Promising Intracellular Protein-Degradation Strategy: TRIMbody-Away Technique Based on Nanobody Fragment

(2021) Gang Chen et al.   Biomolecules

Enabling the next steps in cancer immunotherapy: from antibody-based bispecifics to multispecifics, with an evolving role for bioconjugation chemistry

(2021) Fabien Thoreau et al.   RSC Chemical Biology

Generation of bispecific antibodies using chemical conjugation methods

(2021) Nazzareno Dimasi et al.   Drug Discovery Today: Technologies

Nanoneedle Platforms: The Many Ways to Pierce the Cell Membrane

(2020) Gen He et al.   ADVANCED FUNCTIONAL MATERIALS

Aggregation-Induced Emission: New Vistas at Aggregate Level

(2020) Ben Zhong Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Smart Design of Nanomaterials for Mitochondria-Targeted Nanotherapeutics

(2020) Shao Q. Yao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody glycosylation: impact on antibody drug characteristics and quality control

(2020) Ziyan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Detection and destruction of HER2‐positive cancer cells by Ultra Quenchbody‐siRNA complex

(2020) Jinhua Dong et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recent progress in antitumor functions of the intracellular antibodies

(2020) Yunfeng Lin et al.   DRUG DISCOVERY TODAY

Cryopolymerization of 1,2-Dithiolanes for the Facile and Reversible Grafting-from Synthesis of Protein–Polydisulfide Conjugates

(2020) Jianhua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Cytosolic Delivery of Proteins through Coengineering of Proteins and Polymeric Delivery Vehicles

(2020) Yi-Wei Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action

(2020) Xuesai Zhang et al.   MOLECULAR IMMUNOLOGY

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

(2020) John D. Martin et al.   Nature Reviews Clinical Oncology

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Microenvironment mapping via Dexter energy transfer on immune cells

(2020) Jacob B. Geri et al.   SCIENCE

Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

(2020) Yingqian Zhang et al.   Nature Communications

Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

(2020) Imran Ali et al.   Polymers

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

(2020) Marı́a Maneiro et al.   ACS Chemical Biology

Nanocarrier‐Mediated Cytosolic Delivery of Biopharmaceuticals

(2020) Wei He et al.   ADVANCED FUNCTIONAL MATERIALS

Recent progress in transglutaminase-mediated assembly of antibody-drug conjugates

(2020) Hendrik Schneider et al.   ANALYTICAL BIOCHEMISTRY

Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

(2020) Romain Tessier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Methods for protein delivery into cells: from current approaches to future perspectives

(2020) Chalmers Chau et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology

(2020) Congcong Zhang et al.   BIODRUGS

Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics

(2020) Heliang Li et al.   Cellular & Molecular Immunology

ImmunoPET: Concept, Design, and Applications

(2020) Weijun Wei et al.   CHEMICAL REVIEWS

Trastuzumab Deruxtecan: First Approval

(2020) Susan J. Keam   DRUGS

Small molecules, big impact: 20 years of targeted therapy in oncology

(2020) Philippe L Bedard et al.   LANCET

Top companies and drugs by sales in 2019

(2020) Lisa Urquhart   NATURE REVIEWS DRUG DISCOVERY

On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency

(2020) Igor Dovgan et al.   Scientific Reports

Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application

(2020) Jing Xie et al.   Frontiers in Pharmacology

FcγR Binding and ADCC Activity of Human IgG Allotypes

(2020) Steven W. de Taeye et al.   Frontiers in Immunology

Computational Design of an Allosteric Antibody Switch by Deletion and Rescue of a Complex Structural Constellation

(2020) Jittasak Khowsathit et al.   ACS Central Science

Surface-Mediated Intracellular Delivery by Physical Membrane Disruption

(2020) Yangcui Qu et al.   ACS Applied Materials & Interfaces

Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

(2020) David C. Luther et al.   ADVANCED DRUG DELIVERY REVIEWS

Development of a Versatile and Modular Linker for Antibody–Drug Conjugates Based on Oligonucleotide Strand Pairing

(2020) Nai-Shu Hsu et al.   BIOCONJUGATE CHEMISTRY

Novel HER2‐targeted therapies for HER2‐positive metastatic breast cancer

(2020) Siddharth Kunte et al.   CANCER

Postmarketing safety‐related regulatory actions for new therapeutic biologics approved in the U.S. 2002 ‐ 2014: Similarities and differences with new molecular entities

(2020) Ilynn Bulatao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A High-Denticity Chelator Based on Desferrioxamine for Enhanced Coordination of Zirconium-89

(2020) Elaheh Khozeimeh Sarbisheh et al.   INORGANIC CHEMISTRY

ARX788, a Site-specific anti-HER2 Antibody Drug Conjugate, Demonstrates Potent and Selective Activity in HER2 Low and T-DM1 Resistant Breast and Gastric Cancers

(2020) Lillian Skidmore et al.   MOLECULAR CANCER THERAPEUTICS

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

New class of molecule targets proteins outside cells for degradation

(2020) Claire Whitworth et al.   NATURE

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

(2020) Tao Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS

(2020) Nicolas Bery et al.   Nature Communications

Development of light-responsive protein binding in the monobody non-immunoglobulin scaffold

(2020) César Carrasco-López et al.   Nature Communications

Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting

(2020) Mahmoud Labib et al.   Nature Biomedical Engineering

Recent progress in the molecular imaging of therapeutic monoclonal antibodies

(2020) Kaifeng He et al.   Journal of Pharmaceutical Analysis

Recent Advances in Stimuli-Responsive Platforms for Cancer Immunotherapy

(2020) Ling Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

When liposomes met antibodies: Drug delivery and beyond

(2020) Jiaxing Di et al.   ADVANCED DRUG DELIVERY REVIEWS

Cellular‐ and Subcellular‐Targeted Delivery Using a Simple All‐in‐One Polymeric Nanoassembly

(2020) Jingjing Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanobodies: The Future of Antibody-Based Immune Therapeutics

(2020) Nuthan V. Bathula et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status

(2020) Tarek Mohamed Abd El-Aziz et al.   INFECTION GENETICS AND EVOLUTION

Toward Drug-Like Multispecific Antibodies by Design

(2020) Manali S. Sawant et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phage Display Derived Monoclonal Antibodies: From Bench to Bedside

(2020) Mohamed A. Alfaleh et al.   Frontiers in Immunology

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

(2020) Wen Shi Lee et al.   Nature Microbiology

Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery

(2020) Ji Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Tuning of Domain Stoichiometry in Nanobody–Enzyme Megamolecules

(2020) Kevin J. Metcalf et al.   BIOCONJUGATE CHEMISTRY

An overview of process development for antibody-drug conjugates produced by chemical conjugation technology

(2020) Yutaka Matsuda et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Antibody and antibody fragments for cancer immunotherapy

(2020) Weizhi Chen et al.   JOURNAL OF CONTROLLED RELEASE

Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery

(2020) Bethany Almeida et al.   MOLECULES

Cell-Permeant Bioadaptors for Cytosolic Delivery of Native Antibodies: A “Mix-and-Go” Approach

(2020) Shubo Du et al.   ACS Central Science

Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States

(2020) Shuhui Lim et al.   ACS Central Science

Nanobodies Right in the Middle: Intrabodies as Toolbox to Visualize and Modulate Antigens in the Living Cell

(2020) Teresa R. Wagner et al.   Biomolecules

An Inside Job: Applications of Intracellular Single Domain Antibodies

(2020) Eline Soetens et al.   Biomolecules

Extracellular vesicles: A bright star of nanomedicine

(2020) Peipei Wu et al.   BIOMATERIALS

Optimization of Enzymatic Antibody Fragmentation for Yield, Efficiency, and Binding Affinity

(2019) Andrew W. L. Kinman et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Chemical Conjugation of Antibodies by Using Affinity Peptide for the Development of Therapeutic Antibody Format

(2019) Satoshi Kishimoto et al.   BIOCONJUGATE CHEMISTRY

Controlled EGFR ligand display on cancer suicide enzymes via UAA engineering for enhanced intracellular delivery in breast cancer cells

(2019) Rachel M Lieser et al.   BIOCONJUGATE CHEMISTRY

New therapeutic perspectives to manage refractory immune checkpoint-related toxicities

(2019) Filipe Martins et al.   LANCET ONCOLOGY

Antibody–Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity

(2019) Dario Neri   Cancer Immunology Research

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

Antibody-Drug Conjugate-Based Therapeutics: State of the Science

(2019) Michael J Birrer et al.   JNCI-Journal of the National Cancer Institute

DNA-Functionalized Metal–Organic Framework Nanoparticles for Intracellular Delivery of Proteins

(2019) Shunzhi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme-Mediated Intercellular Proximity Labeling for Detecting Cell–Cell Interactions

(2019) Yun Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adeno-Associated Virus Delivery of Anti-HIV Monoclonal Antibodies Can Drive Long-Term Virologic Suppression

(2019) José M. Martinez-Navio et al.   IMMUNITY

Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential

(2019) Khushboo Singh et al.   BIOCONJUGATE CHEMISTRY

Membrane Electroporation and Electropermeabilization: Mechanisms and Models

(2019) Tadej Kotnik et al.   Annual Review of Biophysics

AJICAP: Affinity Peptide Mediated Regiodivergent Functionalization of Native Antibodies

(2019) Kei Yamada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy

(2019) Lei Han et al.   ADVANCED MATERIALS

A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System

(2019) Di Wu et al.   ADVANCED MATERIALS

Esterification Delivers a Functional Enzyme into a Human Cell

(2019) Valerie T. Ressler et al.   ACS Chemical Biology

Contemporary approaches to site-selective protein modification

(2019) Emily A. Hoyt et al.   Nature Reviews Chemistry

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

(2019) Nadine Eliane Schmit et al.   ACS Chemical Biology

Mitochondria-Targeting, Intracellular Delivery of Native Proteins Using Biodegradable Silica Nanoparticles

(2019) Peiyan Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C-Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation

(2019) Marion Garreau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual Site-Specific Antibody Conjugates for Sequential and Orthogonal Cargo Release

(2019) Dana N. Thornlow et al.   BIOCONJUGATE CHEMISTRY

Understanding Cell Penetration of Cyclic Peptides

(2019) Patrick G. Dougherty et al.   CHEMICAL REVIEWS

Complement System: a Neglected Pathway in Immunotherapy

(2019) Anne Bordron et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations

(2019) Roman V. Kholodenko et al.   CURRENT MEDICINAL CHEMISTRY

Targets for MAbs: innovative approaches for their discovery & validation, LabEx MAbImprove 6th antibody industrial symposium, June 25-26, 2018, Montpellier, France

(2019) Pierre Martineau et al.   mAbs

A review of bispecific antibodies and antibody constructs in oncology and clinical challenges

(2019) Frans V. Suurs et al.   PHARMACOLOGY & THERAPEUTICS

Antibody and antibody derivatives as cancer therapeutics

(2019) Keith J. Arlotta et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates

(2019) Marc-André Kasper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents

(2019) Igor Dovgan et al.   BIOCONJUGATE CHEMISTRY

Cyclic Cell‐Penetrating Peptides with Single Hydrophobic Groups

(2019) Jian Song et al.   CHEMBIOCHEM

Considerations for the Design of Antibody-Based Therapeutics

(2019) Dennis R. Goulet et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life

(2019) Brian C. Mackness et al.   mAbs

Cyclic Cell-Penetrating Peptides As Efficient Intracellular Drug Delivery Tools

(2019) Shang Eun Park et al.   MOLECULAR PHARMACEUTICS

Randomized phase I clinical trial of anti–α‐synuclein antibody BIIB054

(2019) Miroslaw Brys et al.   MOVEMENT DISORDERS

Click chemistry targets antibody-drug conjugates for the clinic

(2019) Mark Peplow   NATURE BIOTECHNOLOGY

Pre-market development times for biologic versus small-molecule drugs

(2019) Reed F. Beall et al.   NATURE BIOTECHNOLOGY

Bispecific antibodies: a mechanistic review of the pipeline

(2019) Aran F. Labrijn et al.   NATURE REVIEWS DRUG DISCOVERY

Antibody therapeutics and immunoregulation in cancer and autoimmune disease

(2019) Masahiro Yasunaga   SEMINARS IN CANCER BIOLOGY

Gold nanoparticles in chemo-, immuno-, and combined therapy: review [Invited]

(2019) L. A. Dykman et al.   Biomedical Optics Express

Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life

(2019) Kevin O. Saunders   Frontiers in Immunology

Understanding Fc Receptor Involvement in Inflammatory Diseases: From Mechanisms to New Therapeutic Tools

(2019) Sanae Ben Mkaddem et al.   Frontiers in Immunology

Novel Silyl Ether-Based Acid-Cleavable Antibody-MMAE Conjugates with Appropriate Stability and Efficacy

(2019) Yanming Wang et al.   Cancers

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

(2019) Dangge Wang et al.   Science Immunology

Rational Design of Nanocarriers for Intracellular Protein Delivery

(2019) Xiaofei Qin et al.   ADVANCED MATERIALS

Antibody–drug conjugates for cancer

(2019) Cindy H Chau et al.   LANCET

TRIM21—From Intracellular Immunity to Therapy

(2019) Stian Foss et al.   Frontiers in Immunology

Novel Human Bispecific Aptamer–Antibody Conjugates for Efficient Cancer Cell Killing

(2019) Margherita Passariello et al.   Cancers

Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice

(2019) Jing Wen et al.   Nature Biomedical Engineering

Site-Specific Encoding of Photoactivity in Antibodies Enables Light-Mediated Antibody-Antigen Binding on Live Cells

(2019) Thomas Bridge et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular targets as source for cleaner targets for the treatment of solid tumors

(2019) Hans-Peter Gerber et al.   BIOCHEMICAL PHARMACOLOGY

Fast and Efficient Fc-Specific Photoaffinity Labeling To Produce Antibody–DNA Conjugates

(2019) Christiane Stiller et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody–Drug Conjugates

(2019) Dobeen Hwang et al.   BIOCONJUGATE CHEMISTRY

Polymers for cytosolic protein delivery

(2019) Jia Lv et al.   BIOMATERIALS

Understanding how Fc-modification transforms a pathogenic HIT-like monoclonal antibody into a novel treatment for sepsis

(2019) Kandace Gollomp et al.   BLOOD

Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity

(2019) Thomas H. Pillow et al.   ChemMedChem

Boosting therapeutic potency of antibodies by taming Fc domain functions

(2019) Tae Hyun Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Architecture-Controlled Ring-Opening Polymerization for Dynamic Covalent Poly(disulfide)s

(2019) Yun Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications

(2019) Xin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment

(2019) Traian Sulea et al.   mAbs

Antibody-Drug Conjugates: A Comprehensive Review

(2019) Puregmaa Khongorzul et al.   MOLECULAR CANCER RESEARCH

Optimizing Lysosomal Activation of Antibody–Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers

(2019) Paulin L. Salomon et al.   MOLECULAR PHARMACEUTICS

Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins

(2019) Daseuli Yu et al.   NATURE METHODS

Cytosolic delivery of inhibitory antibodies with cationic lipids

(2019) Hejia Henry Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing

(2019) Liqiang Pan et al.   Advanced Science

Computationally designed antibody–drug conjugates self-assembled via affinity ligands

(2019) Nimish Gupta et al.   Nature Biomedical Engineering

Photobodies: Light-Activatable Single-Domain Antibody Fragments

(2019) Benedikt Jedlitzke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

(2019) Peter S. Dragovich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Competition-Based Universal Photonic Crystal Biosensors by Using Antibody–Antigen Interaction

(2019) Junjie Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable Bivalent Peptide–DNA Locks for pH-Based Control of Antibody Activity

(2019) Wouter Engelen et al.   ACS Central Science

Bispecific antibodies in cancer immunotherapy

(2019) Christoph Rader   CURRENT OPINION IN BIOTECHNOLOGY

Rapid detection of the neonicotinoid insecticide imidacloprid using a quenchbody assay

(2018) Shitao Zhao et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Intracellular Delivery of Native Proteins Facilitated by Cell-Penetrating Poly(disulfide)s

(2018) Linghui Qian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanobodies: Chemical Functionalization Strategies and Intracellular Applications

(2018) Dominik Schumacher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Getting in: emerging methods and design principles for cell-penetrant peptides

(2018) Leila Peraro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Dual Labeling of Proteins on Cysteine Residues with Chlorotetrazines

(2018) Coline Canovas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoquencher-Based Selective Imaging of Protein Glutathionylation in Live Mammalian Cells

(2018) Xin Mao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

(2018) Mark Barok et al.   BMC CANCER

Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation

(2018) Grace H. Pham et al.   CHEMBIOCHEM

Single-site labeling of lysine in proteins through a metal-free multicomponent approach

(2018) Maheshwerreddy Chilamari et al.   CHEMICAL COMMUNICATIONS

Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

(2018) Federica Scaletti et al.   CHEMICAL SOCIETY REVIEWS

Advanced physical techniques for gene delivery based on membrane perforation

(2018) Xiaofan Du et al.   DRUG DELIVERY

Functionalized extracellular vesicles as advanced therapeutic nanodelivery systems

(2018) Mei Lu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Glycosylated Cell-Penetrating Poly(disulfide)s: Multifunctional Cellular Uptake at High Solubility

(2018) Paola Morelli et al.   HELVETICA CHIMICA ACTA

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

(2018) Łukasz Opaliński et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemo- and Regioselective Lysine Modification on Native Proteins

(2018) Maria J. Matos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomineralized Metal-Organic Framework Nanoparticles Enable Intracellular Delivery and Endo-Lysosomal Release of Native Active Proteins

(2018) Ting-Ting Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a Light-Controlled Nanoplatform for Direct Nuclear Delivery of Molecular and Nanoscale Materials

(2018) Ya-Xuan Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-terminal α-amino group modification of antibodies using a site-selective click chemistry method

(2018) De-zhi Li et al.   mAbs

The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity

(2018) Natasha A. Pereira et al.   mAbs

Liposomal nanoparticle armed with bivalent bispecific single-domain antibodies, novel weapon in HER2 positive cancerous cell lines targeting

(2018) Shahryar Khoshtinat Nikkhoi et al.   MOLECULAR IMMUNOLOGY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

The promise and challenges of immune agonist antibody development in cancer

(2018) Patrick A. Mayes et al.   NATURE REVIEWS DRUG DISCOVERY

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

(2018) Chao Wang et al.   Science Translational Medicine

The Increasingly Human and Profitable Monoclonal Antibody Market

(2018) António L. Grilo et al.   TRENDS IN BIOTECHNOLOGY

Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

(2018) Raffaella Rossin et al.   Nature Communications

Bispecific antibodies: design, therapy, perspectives

(2018) Sergey Sedykh et al.   Drug Design Development and Therapy

A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway

(2018) Jun-Fang Zhang et al.   Theranostics

Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human Antibodies

(2018) Weihsu C. Chen et al.   Frontiers in Immunology

Monoclonal Antibody Therapies for Hematological Malignancies: Not Just Lineage-Specific Targets

(2018) Carlos Cuesta-Mateos et al.   Frontiers in Immunology

Antibody-cytokine fusion proteins: Biopharmaceuticals with immunomodulatory properties for cancer therapy

(2018) Cornelia Hutmacher et al.   ADVANCED DRUG DELIVERY REVIEWS

Antibody-Bridged Beacon for Homogeneous Detection of Small Molecules

(2018) Xiaowen Yan et al.   ANALYTICAL CHEMISTRY

Chemoenzymatic Methods for the Synthesis of Glycoproteins

(2018) Chao Li et al.   CHEMICAL REVIEWS

Cancer cell nucleus-targeting nanocomposites for advanced tumor therapeutics

(2018) Limin Pan et al.   CHEMICAL SOCIETY REVIEWS

Bioconjugation with Maleimides: A useful Tool for Chemical Biology

(2018) Pedro Miguel pimenta Gois et al.   CHEMISTRY-A EUROPEAN JOURNAL

Monitoring T cell–dendritic cell interactions in vivo by intercellular enzymatic labelling

(2018) Giulia Pasqual et al.   NATURE

A proximity-tagging system to identify membrane protein–protein interactions

(2018) Qiang Liu et al.   NATURE METHODS

Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies

(2018) A. Klein et al.   Chemical Science

Synthetic materials at the forefront of gene delivery

(2018) Irene Lostalé-Seijo et al.   Nature Reviews Chemistry

Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing

(2018) Jin Chang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Convenient and Universal Fabrication Method for Antibody–Enzyme Complexes as Sensing Elements Using the SpyCatcher/SpyTag System

(2018) Hayato Kimura et al.   ANALYTICAL CHEMISTRY

Recent Progress in Chemical Modification of Proteins

(2018) Seiji SAKAMOTO et al.   ANALYTICAL SCIENCES

Radiochemistry in a flash: photochemical conjugation and one-pot radiolabelling of antibodies for immuno-PET

(2018) Malay Patra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proximity-Induced Site-Specific Antibody Conjugation

(2018) Chenfei Yu et al.   BIOCONJUGATE CHEMISTRY

Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads

(2018) Amit Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Developing an antibody-drug conjugate approach to selective inhibition of an extracellular protein

(2018) Elizabeth Love et al.   CHEMBIOCHEM

Selective delivery of doxorubicin to EGFR+ cancer cells by Cetuximab-DNA conjugates

(2018) Kurt Vesterager Gothelf et al.   CHEMBIOCHEM

Shark IgNAR-derived binding domains as potential diagnostic and therapeutic agents

(2018) Hanover Matz et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering

(2018) Kenta Haraya et al.   Drug Metabolism and Pharmacokinetics

Emicizumab, a humanized bispecific antibody to coagulation factors IXa and X with a factor VIIIa-cofactor activity

(2018) Takehisa Kitazawa et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Bypassing Endocytosis: Direct Cytosolic Delivery of Proteins

(2018) Shubo Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potent Protein Delivery into Mammalian Cells via a Supercharged Polypeptide

(2018) Jun Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems

(2018) Tomonori Tamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering therapeutic bispecific antibodies using CrossMab technology

(2018) Christian Klein et al.   METHODS

A Review on Electroporation-Based Intracellular Delivery

(2018) Junfeng Shi et al.   MOLECULES

Polymer–drug conjugate therapeutics: advances, insights and prospects

(2018) Iriny Ekladious et al.   NATURE REVIEWS DRUG DISCOVERY

Targeted Intracellular Delivery of Antibodies: The State of the Art

(2018) Tatiana A. Slastnikova et al.   Frontiers in Pharmacology

Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates

(2017) Sergii Kolodych et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glycosylation of IgG-Fc: a molecular perspective

(2017) Masato Kiyoshi et al.   INTERNATIONAL IMMUNOLOGY

Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload

(2017) Yanming Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug Conjugates

(2017) Ying Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery

(2017) Girgis Obaid et al.   JOURNAL OF BIOMEDICAL OPTICS

Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future

(2017) Heather E. Vezina et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Targeted cancer therapy through antibody fragments-decorated nanomedicines

(2017) Abbas Alibakhshi et al.   JOURNAL OF CONTROLLED RELEASE

Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

(2017) BinQing Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Hexa-rhodium Metallopeptide Catalyst for Site-Specific Functionalization of Natural Antibodies

(2017) Jun Ohata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones

(2017) Yingqian Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags

(2017) Rui Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cytosolic Delivery of Proteins by Bioreversible Esterification

(2017) Kalie A. Mix et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The making of bispecific antibodies

(2017) Ulrich Brinkmann et al.   mAbs

Bispecific Antibodies and Antibody–Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs

(2017) Julian Andreev et al.   MOLECULAR CANCER THERAPEUTICS

Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity

(2017) Daniela Kalafatovic et al.   MOLECULES

Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries

(2017) Joel W Blanchard et al.   NATURE BIOTECHNOLOGY

Targeting the N terminus for site-selective protein modification

(2017) Christian B Rosen et al.   Nature Chemical Biology

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

(2017) Misao Akishiba et al.   Nature Chemistry

Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials

(2017) Steven Bloom et al.   Nature Chemistry

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells

(2017) Henry D. Herce et al.   Nature Chemistry

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Next generation antibody drugs: pursuit of the 'high-hanging fruit'

(2017) Paul J. Carter et al.   NATURE REVIEWS DRUG DISCOVERY

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?

(2017) Michaela Seeling et al.   Nature Reviews Rheumatology

Stimuli-responsive polymers and their applications

(2017) Menglian Wei et al.   Polymer Chemistry

Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer Therapy

(2017) Christian Kellner et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

(2017) Yong Tae Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

Affibody Molecules in Biotechnological and Medical Applications

(2017) Stefan Ståhl et al.   TRENDS IN BIOTECHNOLOGY

The Immunoregulatory Roles of Antibody Glycosylation

(2017) Madeleine F. Jennewein et al.   TRENDS IN IMMUNOLOGY

A red-emissive antibody–AIEgen conjugate for turn-on and wash-free imaging of specific cancer cells

(2017) Xiujuan Shi et al.   Chemical Science

Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates

(2017) Alex R. Nanna et al.   Nature Communications

Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates

(2017) Muhammad Kalim et al.   Drug Design Development and Therapy

Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody

(2017) Eifion Robinson et al.   RSC Advances

A quantitative comparison of cytosolic delivery via different protein uptake systems

(2017) Wouter P. R. Verdurmen et al.   Scientific Reports

Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models

(2017) Chunlei Guo et al.   Theranostics

Development of a CHO-Based Cell-Free Platform for Synthesis of Active Monoclonal Antibodies

(2017) Rey W. Martin et al.   ACS Synthetic Biology

Recent Advances in the Generation of Antibody-Nanomaterial Conjugates

(2017) Amal J. Sivaram et al.   Advanced Healthcare Materials

Current progress in innovative engineered antibodies

(2017) William R. Strohl   Protein & Cell

Therapeutic Antibodies against Intracellular Tumor Antigens

(2017) Iva Trenevska et al.   Frontiers in Immunology

Antibody or Antibody Fragments: Implications for Molecular Imaging and Targeted Therapy of Solid Tumors

(2017) Katerina T. Xenaki et al.   Frontiers in Immunology

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

(2017) Peter Bannas et al.   Frontiers in Immunology

Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains

(2017) I-Ju Chen et al.   Scientific Reports

Ultrastable and Biofunctionalizable Gold Nanoparticles

(2016) Akash Gupta et al.   ACS Applied Materials & Interfaces

Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer

(2016) Haiqiang Cao et al.   ACS Nano

Covalent and Oriented Surface Immobilization of Antibody Using Photoactivatable Antibody Fc-Binding Protein Expressed in Escherichia coli

(2016) Yeolin Lee et al.   ANALYTICAL CHEMISTRY

Orthogonal Cysteine Protection Enables Homogeneous Multi-Drug Antibody-Drug Conjugates

(2016) Matthew R. Levengood et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell-Penetrating Poly(disulfide) Assisted Intracellular Delivery of Mesoporous Silica Nanoparticles for Inhibition of miR-21 Function and Detection of Subsequent Therapeutic Effects

(2016) Changmin Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drugging Undruggable Molecular Cancer Targets

(2016) John S. Lazo et al.   Annual Review of Pharmacology and Toxicology

Immuno-PCR: achievements and perspectives

(2016) D. Y. Ryazantsev et al.   BIOCHEMISTRY-MOSCOW

Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs

(2016) Jeffrey C. Kern et al.   BIOCONJUGATE CHEMISTRY

Future of nanotherapeutics: Targeting the cellular sub-organelles

(2016) Xiaowei Ma et al.   BIOMATERIALS

Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads

(2016) Takashi Nakada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Therapeutic monoclonal antibodies and derivatives: Historical perspectives and future directions

(2016) Kyla R. Rodgers et al.   BIOTECHNOLOGY ADVANCES

Immune-related adverse events with immune checkpoint blockade: a comprehensive review

(2016) J.M. Michot et al.   EUROPEAN JOURNAL OF CANCER

Opportunities and challenges for TCR mimic antibodies in cancer therapy

(2016) Aaron Y. Chang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cell-penetrating peptides with intracellular organelle targeting

(2016) Carmine Pasquale Cerrato et al.   Expert Opinion on Drug Delivery

The ubiquitin-proteasome system and autophagy: Coordinated and independent activities

(2016) Victoria Cohen-Kaplan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

An l- to d-Amino Acid Conversion in an Endosomolytic Analog of the Cell-penetrating Peptide TAT Influences Proteolytic Stability, Endocytic Uptake, and Endosomal Escape

(2016) Kristina Najjar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding

(2016) Emma Davé et al.   mAbs

Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins

(2016) Prince Awuah et al.   MOLECULAR CANCER THERAPEUTICS

Mechanisms of Resistance to Antibody–Drug Conjugates

(2016) Frank Loganzo et al.   MOLECULAR CANCER THERAPEUTICS

A New Triglycyl Peptide Linker for Antibody–Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells

(2016) Rajeeva Singh et al.   MOLECULAR CANCER THERAPEUTICS

Altering Antibody–Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability

(2016) Kevin J. Hamblett et al.   MOLECULAR PHARMACEUTICS

Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins

(2016) David J Marshall et al.   MOLECULAR THERAPY

First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers

(2016) Dale B. Schenk et al.   MOVEMENT DISORDERS

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

(2016) Chao Wang et al.   NANO LETTERS

In vitro and ex vivo strategies for intracellular delivery

(2016) Martin P. Stewart et al.   NATURE

Development and application of bond cleavage reactions in bioorthogonal chemistry

(2016) Jie Li et al.   Nature Chemical Biology

Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy

(2016) Yusuke Sakiyama et al.   Nature Nanotechnology

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

Ethynyl benziodoxolones: functional terminators for cell-penetrating poly(disulfide)s

(2016) Paola Morelli et al.   Polymer Chemistry

Precision glycocalyx editing as a strategy for cancer immunotherapy

(2016) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Nanostructures Carrying Stoichiometrically Definable Antibodies

(2016) Magdiel Inggrid Setyawati et al.   Small

Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry

(2016) Padma Akkapeddi et al.   Chemical Science

Next-generation disulfide stapling: reduction and functional re-bridging all in one

(2016) Maximillian T. W. Lee et al.   Chemical Science

Straightforward Glycoengineering Approach to Site-Specific Antibody–Pyrrolobenzodiazepine Conjugates

(2016) Pamela Thompson et al.   ACS Medicinal Chemistry Letters

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

(2016) Kyoji Tsuchikama et al.   Protein & Cell

Leveraging the attributes of biologics and small molecules, and releasing the bottlenecks: a new wave of revolution in drug development

(2016) Charles Oo et al.   Expert Review of Clinical Pharmacology

Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm?

(2016) Andrea L.J. Marschall et al.   Computational and Structural Biotechnology Journal

Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry

(2015) Jessica R. McCombs et al.   AAPS Journal

The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy

(2015) Jonathan T. Sockolosky et al.   ADVANCED DRUG DELIVERY REVIEWS

IgG subclass specificity to C1q determined by surface plasmon resonance using Protein L capture technique

(2015) Rekha Patel et al.   ANALYTICAL BIOCHEMISTRY

Protein Delivery System Containing a Nickel-Immobilized Polymer for Multimerization of Affinity-Purified His-Tagged Proteins Enhances Cytosolic Transfer

(2015) Viktoriia Postupalenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Breakable Hybrid Organosilica Nanocapsules for Protein Delivery

(2015) Eko Adi Prasetyanto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Perspective on the Structure and Receptor Binding Properties of Immunoglobulin G Fc

(2015) Quinlin M. Hanson et al.   BIOCHEMISTRY

Hydrolytically Stable Site-Specific Conjugation at the N-Terminus of an Engineered Antibody

(2015) Pamela Thompson et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

(2015) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Antibody-drug conjugates as novel anti-cancer chemotherapeutics

(2015) C. Peters et al.   BIOSCIENCE REPORTS

Releasing the Brakes on Cancer Immunotherapy

(2015) Dan R. Littman   CELL

Cellular uptake: lessons from supramolecular organic chemistry

(2015) Giulio Gasparini et al.   CHEMICAL COMMUNICATIONS

Protein–polymer conjugation—moving beyond PEGylation

(2015) Yizhi Qi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases

(2015) Yuping Lai et al.   INTERNATIONAL IMMUNOLOGY

A Fusion Protein of RGD4C and β-Lactamase Has a Favorable Targeting Effect in Its Use in Antibody Directed Enzyme Prodrug Therapy

(2015) Hao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Site-Specific PEGylation of Therapeutic Proteins

(2015) Jonathan Dozier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides

(2015) R. James Christie et al.   JOURNAL OF CONTROLLED RELEASE

PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo

(2015) Kadi-Liis Veiman et al.   JOURNAL OF CONTROLLED RELEASE

Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo

(2015) Margie Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of Cell-Surface Receptor Dynamics through Covalent Labeling by Catalyst-Tethered Antibody

(2015) Takahiro Hayashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intracellular Delivery of Functional Proteins and Native Drugs by Cell-Penetrating Poly(disulfide)s

(2015) Jiaqi Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

 De novoisolation of antibodies with pH-dependent binding properties

(2015) Pauline Bonvin et al.   mAbs

Influence of molecular size on tissue distribution of antibody fragments

(2015) Zhe Li et al.   mAbs

Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation

(2015) Michal Bassani-Sternberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

(2015) Vashti Irani et al.   MOLECULAR IMMUNOLOGY

In vivo imaging with antibodies and engineered fragments

(2015) Amanda C. Freise et al.   MOLECULAR IMMUNOLOGY

Antibody Conjugates with Unnatural Amino Acids

(2015) Trevor J. Hallam et al.   MOLECULAR PHARMACEUTICS

Light-Controlled Delivery of Monoclonal Antibodies for Targeted Photoinactivation of Ki-67

(2015) Sijia Wang et al.   MOLECULAR PHARMACEUTICS

Organometallic palladium reagents for cysteine bioconjugation

(2015) Ekaterina V. Vinogradova et al.   NATURE

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

(2015) James I MacDonald et al.   Nature Chemical Biology

Site-selective protein-modification chemistry for basic biology and drug development

(2015) Nikolaus Krall et al.   Nature Chemistry

Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

(2015) Nicolas Chuard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

(2015) Pietro Sormanni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic antibodies: their mechanisms of action and the pathological findings they induce in toxicity studies

(2015) Masami Suzuki et al.   Journal of Toxicologic Pathology

Proximity-dependent initiation of hybridization chain reaction

(2015) Björn Koos et al.   Nature Communications

History of passive antibody administration for prevention and treatment of infectious diseases

(2015) Barney S. Graham et al.   Current Opinion in HIV and AIDS

NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

(2015) Wei Wang   Frontiers in Immunology

T cell receptor mimic antibodies for cancer therapy

(2015) Leonid Dubrovsky et al.   OncoImmunology

Targeted delivery of protein and gene medicines through the blood-brain barrier

(2015) WM Pardridge   CLINICAL PHARMACOLOGY & THERAPEUTICS

Preparation of Well-Defined Antibody-Drug Conjugates through Glycan Remodeling and Strain-Promoted Azide-Alkyne Cycloadditions

(2014) Xiuru Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy

(2014) Ming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From fluorescence polarization to Quenchbody: Recent progress in fluorescent reagentless biosensors based on antibody and other binding proteins

(2014) Hiroshi Ueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bridging Disulfides for Stable and Defined Antibody Drug Conjugates

(2014) George Badescu et al.   BIOCONJUGATE CHEMISTRY

Selective Irreversible Chemical Tagging of Cysteine with 3-Arylpropiolonitriles

(2014) Oleksandr Koniev et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Antibody–Drug Conjugation through Glycoengineering

(2014) Qun Zhou et al.   BIOCONJUGATE CHEMISTRY

Promises and Pitfalls of Intracellular Delivery of Proteins

(2014) Ailing Fu et al.   BIOCONJUGATE CHEMISTRY

Nucleic acid-mediated intracellular protein delivery by lipid-like nanoparticles

(2014) Ahmed A. Eltoukhy et al.   BIOMATERIALS

Trastuzumab emtansine: mechanisms of action and drug resistance

(2014) Mark Barok et al.   BREAST CANCER RESEARCH

Immunoglobulin Replacement Therapy: A Twenty-Year Review and Current Update

(2014) Monika Saeedian et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

(2014) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering

(2014) Yuan Wang et al.   JOURNAL OF DRUG TARGETING

Natural Antibodies Bridge Innate and Adaptive Immunity

(2014) Saswati Panda et al.   JOURNAL OF IMMUNOLOGY

Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s

(2014) Giulio Gasparini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody

(2014) Céline Monnet et al.   mAbs

Antibodies directed against receptor tyrosine kinases

(2014) Bénédicte FAUVEL et al.   mAbs

Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

(2014) Victoria Hung et al.   MOLECULAR CELL

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

(2014) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT

(2014) Ralf Jungmann et al.   NATURE METHODS

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

(2014) Felix F. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Homogenous 96-Plex PEA Immunoassay Exhibiting High Sensitivity, Specificity, and Excellent Scalability

(2014) Erika Assarsson et al.   PLoS One

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer

(2014) Ross Stewart et al.   Journal for ImmunoTherapy of Cancer

“Breeding” Diagnostic Antibodies for Higher Assay Performance: A 250-Fold Affinity-Matured Antibody Mutant Targeting a Small Biomarker

(2013) Hiroyuki Oyama et al.   ANALYTICAL CHEMISTRY

Rapid, Stable, Chemoselective Labeling of Thiols with Julia-Kocieński-like Reagents: A Serum-Stable Alternative to Maleimide-Based Protein Conjugation

(2013) Narihiro Toda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolic Engineering of Monoclonal Antibody Carbohydrates for Antibody–Drug Conjugation

(2013) Nicole M. Okeley et al.   BIOCONJUGATE CHEMISTRY

Enzyme-Mediated Methodology for the Site-Specific Radiolabeling of Antibodies Based on Catalyst-Free Click Chemistry

(2013) Brian M. Zeglis et al.   BIOCONJUGATE CHEMISTRY

Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site

(2013) Nathan J. Alves et al.   BIOMATERIALS

Antibody humanization methods – a review and update

(2013) Yaghoub Safdari et al.   Biotechnology & Genetic Engineering Reviews

Anti-TNF Antibodies in Inflammatory Bowel Disease: Do We Finally Know How it Works?

(2013) Angelos Oikonomopoulos et al.   CURRENT DRUG TARGETS

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

Controversies in IgG replacement therapy in patients with antibody deficiency diseases

(2013) Erwin W. Gelfand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sub-150nm mesoporous silica nanoparticles with tunable pore sizes and well-ordered mesostructure for protein encapsulation

(2013) Jinlou Gu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Substrate-Initiated Synthesis of Cell-Penetrating Poly(disulfide)s

(2013) Eun-Kyoung Bang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Protein Transamination Using N-Methylpyridinium-4-carboxaldehyde

(2013) Leah S. Witus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Antibody–Polymer Conjugates for siRNA Delivery

(2013) Hua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Approaches to improve tumor accumulation and interactions between monoclonal antibodies and immune cells

(2013) Fabrizio Marcucci et al.   mAbs

Targeting endogenous nuclear antigens by electrotransfer of monoclonal antibodies in living cells

(2013) Guillaume Freund et al.   mAbs

Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis

(2013) Pauline A. van Schouwenburg et al.   Nature Reviews Rheumatology

Developing Therapeutic Antibodies for Neurodegenerative Disease

(2013) Y. Joy Yu et al.   Neurotherapeutics

Antibody Therapeutics in Cancer

(2013) M. X. Sliwkowski et al.   SCIENCE

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Reversible blocking of antibodies using bivalent peptide–DNA conjugates allows protease-activatable targeting

(2013) Brian M. G. Janssen et al.   Chemical Science

Microneedles for drug and vaccine delivery

(2012) Yeu-Chun Kim et al.   ADVANCED DRUG DELIVERY REVIEWS

Reagents for Astatination of Biomolecules. 6. An Intact Antibody Conjugated with a Maleimido-closo-Decaborate(2-) Reagent via Sulfhydryl Groups Had Considerably Higher Kidney Concentrations than the Same Antibody Conjugated with an Isothiocyanato-closo-Decaborate(2-) Reagent via Lysine Amines

(2012) D. Scott Wilbur et al.   BIOCONJUGATE CHEMISTRY

DOTAGA-Trastuzumab. A New Antibody Conjugate Targeting HER2/Neu Antigen for Diagnostic Purposes

(2012) Mathieu Moreau et al.   BIOCONJUGATE CHEMISTRY

Influence of architecture of high molecular weight linear and branched polyglycerols on their biocompatibility and biodistribution

(2012) Muhammad Imran ul-haq et al.   BIOMATERIALS

Antigen Shedding May Improve Efficiencies for Delivery of Antibody-Based Anticancer Agents in Solid Tumors

(2012) Y. Pak et al.   CANCER RESEARCH

Antibody-Based Immunotherapy of Cancer

(2012) Louis M. Weiner et al.   CELL

Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format

(2012) Kathrin Zuberbühler et al.   CHEMICAL COMMUNICATIONS

Cellular Uptake Mechanisms and Endosomal Trafficking of Supercharged Proteins

(2012) David B. Thompson et al.   CHEMISTRY & BIOLOGY

Monoclonal antibody therapeutics: history and future

(2012) Nicholas APS Buss et al.   CURRENT OPINION IN PHARMACOLOGY

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

(2012) Tengfei Li et al.   FASEB JOURNAL

CD20 mAb-mediated C3b deposition and complement dependent cytotoxicity of tumor cells is enhanced by blocking the action of Factor I

(2012) Ronald P. Taylor et al.   IMMUNOBIOLOGY

Recombinant peptide constructs for targeted cell penetrating peptide-mediated delivery

(2012) Jennica L. Zaro et al.   JOURNAL OF CONTROLLED RELEASE

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Aglycosylated antibodies and antibody fragments produced in a scalable in vitro transcription-translation system

(2012) Gang Yin et al.   mAbs

Antibody-enabled small-molecule drug discovery

(2012) Alastair D. G. Lawson   NATURE REVIEWS DRUG DISCOVERY

Immuno-Hybridization Chain Reaction for Enhancing Detection of Individual Cytokine-Secreting Human Peripheral Mononuclear Cells

(2011) Jonghoon Choi et al.   ANALYTICAL CHEMISTRY

Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage

(2011) Brenda A. Kellogg et al.   BIOCONJUGATE CHEMISTRY

Near-Infrared pH-Activatable Fluorescent Probes for Imaging Primary and Metastatic Breast Tumors

(2011) Hyeran Lee et al.   BIOCONJUGATE CHEMISTRY

Synthesis of Metal-Organic Frameworks (MOFs): Routes to Various MOF Topologies, Morphologies, and Composites

(2011) Norbert Stock et al.   CHEMICAL REVIEWS

Tailoring nanocarriers for intracellular protein delivery

(2011) Zhen Gu et al.   CHEMICAL SOCIETY REVIEWS

A Class of Human Proteins that Deliver Functional Proteins into Mammalian Cells In Vitro and In Vivo

(2011) James J. Cronican et al.   CHEMISTRY & BIOLOGY

Antibody Conjugate Therapeutics: Challenges and Potential

(2011) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Nuclear drug delivery for cancer chemotherapy

(2011) Meihua Sui et al.   JOURNAL OF CONTROLLED RELEASE

Identification of Amino Acid Residues Responsible for the Release of Free Drug from an Antibody–Drug Conjugate Utilizing Lysine–Succinimidyl Ester Chemistry

(2011) Hung-Wei Chih et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

“Quenchbodies”: Quench-Based Antibody Probes That Show Antigen-Dependent Fluorescence

(2011) Ryoji Abe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multiplexed Homogeneous Proximity Ligation Assays for High-throughput Protein Biomarker Research in Serological Material

(2011) Martin Lundberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood

(2011) Martin Lundberg et al.   NUCLEIC ACIDS RESEARCH

Immuno-PCR: a promising ultrasensitive diagnostic method to detect antigens and antibodies

(2011) Nada Malou et al.   TRENDS IN MICROBIOLOGY

Potent Delivery of Functional Proteins into Mammalian Cellsin Vitroandin VivoUsing a Supercharged Protein

(2010) James J. Cronican et al.   ACS Chemical Biology

Antibody engineering toward high-sensitivity high-throughput immunosensing of small molecules

(2010) Norihiro Kobayashi et al.   ANALYST

Efficient Delivery of Bioactive Antibodies into the Cytoplasm of Living Cells by Charge-Conversional Polyion Complex Micelles

(2010) Yan Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetics of reduction of tyrosine phenoxyl radicals by glutathione

(2010) Lisa K. Folkes et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

How viruses access the nucleus

(2010) Sarah Cohen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intracellular Delivery of a Protein Antigen with an Endosomal-Releasing Polymer Enhances CD8 T-Cell Production and Prophylactic Vaccine Efficacy

(2010) Suzanne Foster et al.   BIOCONJUGATE CHEMISTRY

Gold nanostructures: a class of multifunctional materials for biomedical applications

(2010) Claire M. Cobley et al.   CHEMICAL SOCIETY REVIEWS

Proximity ligation assays: a recent addition to the proteomics toolbox

(2010) Irene Weibrecht et al.   Expert Review of Proteomics

Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications

(2010) J. Löfblom et al.   FEBS LETTERS

Adaptive immunity

(2010) Francisco A. Bonilla et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intracellular Delivery of a Membrane-Impermeable Enzyme in Active Form Using Functionalized Gold Nanoparticles

(2010) Partha Ghosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human immunoglobulin allotypes

(2010) Roy Jefferis et al.   mAbs

High sensitivity detection of cancer in vivo using a dual-controlled activation fluorescent imaging probe based on H-dimer formation and pH activation

(2010) Mikako Ogawa et al.   Molecular BioSystems

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

CD20-Targeted Therapy: The Next Generation of Antibodies

(2010) Tom van Meerten et al.   SEMINARS IN HEMATOLOGY

Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC

(2010) Akito Natsume   Drug Design Development and Therapy

H-Type Dimer Formation of Fluorophores: A Mechanism for Activatable,in VivoOptical Molecular Imaging

(2009) Mikako Ogawa et al.   ACS Chemical Biology

Photoactivable Antibody Binding Protein: Site-Selective and Covalent Coupling of Antibody

(2009) Yongwon Jung et al.   ANALYTICAL CHEMISTRY

Antigen Peptide-Based Immunosensors for Rapid Detection of Antibodies and Antigens

(2009) Ling Tian et al.   ANALYTICAL CHEMISTRY

Charge-Conversional Polyionic Complex Micelles-Efficient Nanocarriers for Protein Delivery into Cytoplasm

(2009) Yan Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New Strategy for the Extension of the Serum Half-Life of Antibody Fragments

(2009) Sabrina Trüssel et al.   BIOCONJUGATE CHEMISTRY

β-Lactam-based approach for the chemical programming of aldolase antibody 38C2

(2009) Julia I. Gavrilyuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antibody-Directed Enzyme Prodrug Therapy: A Promising Approach for a Selective Treatment of Cancer Based on Prodrugs and Monoclonal Antibodies

(2009) Lutz F. Tietze et al.   Chemical Biology & Drug Design

New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging

(2009) Hisataka Kobayashi et al.   CHEMICAL REVIEWS

Electron-Deficient Alkynes as Cleavable Reagents for the Modification of Cysteine-Containing Peptides in Aqueous Medium

(2009) Hoi-Yan Shiu et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo

(2009) H. Ikeda et al.   CLINICAL CANCER RESEARCH

In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies

(2009) M. Ogawa et al.   MOLECULAR CANCER THERAPEUTICS

Development trends for therapeutic antibody fragments

(2009) Aaron L Nelson et al.   NATURE BIOTECHNOLOGY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Two routes for production and purification of Fab fragments in biopharmaceutical discovery research: Papain digestion of mAb and transient expression in mammalian cells

(2009) Yonghong Zhao et al.   PROTEIN EXPRESSION AND PURIFICATION

Comparison of Cellular Uptake Using 22 CPPs in 4 Different Cell Lines

(2008) Judith Mueller et al.   BIOCONJUGATE CHEMISTRY

Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates

(2008) Stephen C. Alley et al.   BIOCONJUGATE CHEMISTRY

The Impact of PEGylation on Biological Therapies

(2008) Francesco M Veronese et al.   BIODRUGS

Single-cell microinjection technology in cell biology

(2008) Yan Zhang et al.   BIOESSAYS

Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes

(2008) Fong-Yu Cheng et al.   BIOMATERIALS

Engineered Antibodies of IgG1/IgG3 Mixed Isotype with Enhanced Cytotoxic Activities

(2008) A. Natsume et al.   CANCER RESEARCH

Fully human antibodies from transgenic mouse and phage display platforms

(2008) Nils Lonberg   CURRENT OPINION IN IMMUNOLOGY

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

(2008) Alain Beck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes

(2008) Yasuteru Urano et al.   NATURE MEDICINE

Strategies for discovering novel cancer biomarkers through utilization of emerging technologies

(2008) Vathany Kulasingam et al.   Nature clinical practice. Oncology