Randomized phase I clinical trial of anti–α‐synuclein antibody BIIB054

Targeted Therapies for Parkinson's Disease: From Genetics to the Clinic

(2018) S. Pablo Sardi et al.   MOVEMENT DISORDERS

Medical and surgical management of advanced Parkinson's disease

(2018) Angelo Antonini et al.   MOVEMENT DISORDERS

The Parkinson Pandemic—A Call to Action

(2018) E. Ray Dorsey et al.   JAMA Neurology

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

(2018) Bradley R. Groveman et al.   Acta Neuropathologica Communications

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

(2018) Andreas Weihofen et al.   NEUROBIOLOGY OF DISEASE

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

(2017) Mohammad Shahnawaz et al.   JAMA Neurology

Pre-existing Antibody: Biotherapeutic Modality-Based Review

(2016) Boris Gorovits et al.   AAPS Journal

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

(2016) Graham Fairfoul et al.   Annals of Clinical and Translational Neurology

The epidemiology of silent brain infarction: a systematic review of population-based cohorts

(2014) Jonathon P Fanning et al.   BMC Medicine

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

(2014) Veronica Lindström et al.   NEUROBIOLOGY OF DISEASE

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Nathanael L. Dirks et al.   CLINICAL PHARMACOKINETICS

Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results

(2008) Christopher G. Goetz et al.   MOVEMENT DISORDERS