Biomaterials‐Based Delivery of Therapeutic Antibodies for Cancer Therapy

Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy

(2021) Cheng-Tao Jiang et al.   Nature Communications

Protein Binding Affinity of Polymeric Nanoparticles as a Direct Indicator of Their Pharmacokinetics

(2020) Zhi-Ting Cao et al.   ACS Nano

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

(2020) S. Depil et al.   NATURE REVIEWS DRUG DISCOVERY

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

(2020) Candice R. Gurbatri et al.   Science Translational Medicine

Targeted anti–IL-1β platelet microparticles for cardiac detoxing and repair

(2020) Zhenhua Li et al.   Science Advances

Bifunctional N-Heterocyclic Carbenes Derived from l-Pyroglutamic Acid and Their Applications in Enantioselective Organocatalysis

(2020) Xiang-Yu Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis

(2020) Young-Hyeon An et al.   ACS Nano

Nanobody‐Ferritin Conjugate for Targeted Photodynamic Therapy

(2020) Manman Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

The clearance and biodistribution of magnetic composite nanoparticles in healthy and osteoarthritic rat knees

(2020) Brittany D. Partain et al.   JOURNAL OF CONTROLLED RELEASE

Multispecific drugs herald a new era of biopharmaceutical innovation

(2020) Raymond J. Deshaies   NATURE

Top companies and drugs by sales in 2019

(2020) Lisa Urquhart   NATURE REVIEWS DRUG DISCOVERY

Bispecific Antibodies for Multiple Myeloma: A Review of Targets, Drugs, Clinical Trials, and Future Directions

(2020) Chiara Caraccio et al.   Frontiers in Immunology

Multifunctional surface microrollers for targeted cargo delivery in physiological blood flow

(2020) Yunus Alapan et al.   Science Robotics

Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

(2020) David C. Luther et al.   ADVANCED DRUG DELIVERY REVIEWS

Ionic Liquids and Deep Eutectic Solvents for Enhanced Delivery of Antibodies in the Gastrointestinal Tract

(2020) Pavimol Angsantikul et al.   ADVANCED FUNCTIONAL MATERIALS

Advances in Antimicrobial Microneedle Patches for Combating Infections

(2020) Rezvan Jamaledin et al.   ADVANCED MATERIALS

Nanoscale Metal–Organic Framework Co-delivers TLR-7 Agonists and Anti-CD47 Antibodies to Modulate Macrophages and Orchestrate Cancer Immunotherapy

(2020) Kaiyuan Ni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy

(2020) Kin Man Au et al.   Science Advances

A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control

(2020) Bo Zhi Chen et al.   Science Advances

Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

(2020) Mohammad Hosein Ayoubi‐Joshaghani et al.   ADVANCED FUNCTIONAL MATERIALS

A Multistage Cooperative Nanoplatform Enables Intracellular Co‐Delivery of Proteins and Chemotherapeutics for Cancer Therapy

(2020) Peng Zhang et al.   ADVANCED MATERIALS

Clinical benefit of immune checkpoint inhibitors approved by US Food and Drug Administration

(2020) Fei Liang et al.   BMC CANCER

100th Anniversary of Macromolecular Science Viewpoint: Biological Stimuli-Sensitive Polymer Prodrugs and Nanoparticles for Tumor-Specific Drug Delivery

(2020) Huanli Sun et al.   ACS Macro Letters

Engineering Prodrug Nanomedicine for Cancer Immunotherapy

(2020) Bin Yang et al.   Advanced Science

Antibody and antibody fragments for cancer immunotherapy

(2020) Weizhi Chen et al.   JOURNAL OF CONTROLLED RELEASE

Carrier-free nanoassembly of doxorubicin prodrug and siRNA for combinationally inducing immunogenic cell death and reversing immunosuppression

(2020) Senbiao Chen et al.   Nano Today

Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery

(2019) Zhe Li et al.   Expert Opinion on Drug Delivery

Vesicular Antibodies: A Bioactive Multifunctional Combination Platform for Targeted Therapeutic Delivery and Cancer Immunotherapy

(2019) Xue Liu et al.   ADVANCED MATERIALS

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

(2019) Huitong Ruan et al.   ADVANCED MATERIALS

Mitochondria-Targeting, Intracellular Delivery of Native Proteins Using Biodegradable Silica Nanoparticles

(2019) Peiyan Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody- drug conjugates

(2019) Donglu Zhang et al.   DRUG METABOLISM AND DISPOSITION

Recent advances of microneedles for biomedical applications: drug delivery and beyond

(2019) Jian Yang et al.   Acta Pharmaceutica Sinica B

High Co-loading Capacity and Stimuli-Responsive Release Based on Cascade Reaction of Self-Destructive Polymer for Improved Chemo-Photodynamic Therapy

(2019) Menglin Wang et al.   ACS Nano

Platelets as platforms for inhibition of tumor recurrence post-physical therapy by delivery of anti-PD-L1 checkpoint antibody

(2019) Xiao Han et al.   JOURNAL OF CONTROLLED RELEASE

Improving the Shape Yield and Long-Term Stability of Gold Nanoprisms with Poly(vinylpyrrolidone)

(2019) Katherinne I. Requejo et al.   LANGMUIR

Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy

(2019) Qian Chen et al.   NANO LETTERS

Bispecific antibodies: a mechanistic review of the pipeline

(2019) Aran F. Labrijn et al.   NATURE REVIEWS DRUG DISCOVERY

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

(2019) Dangge Wang et al.   Science Immunology

Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem

(2019) Jiayan Lang et al.   ACS Nano

Rational Design of Nanocarriers for Intracellular Protein Delivery

(2019) Xiaofei Qin et al.   ADVANCED MATERIALS

Antibody–drug conjugates for cancer

(2019) Cindy H Chau et al.   LANCET

Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti‐Metastatic Immunotherapy

(2019) Zheng Wang et al.   Advanced Science

Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice

(2019) Jing Wen et al.   Nature Biomedical Engineering

A Nanoscale Metal-Organic Framework to Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy

(2019) Kaiyuan Ni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polymers for cytosolic protein delivery

(2019) Jia Lv et al.   BIOMATERIALS

Myeloid immunosuppression and immune checkpoints in the tumor microenvironment

(2019) Kyohei Nakamura et al.   Cellular & Molecular Immunology

Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

(2019) Liping Huang et al.   Nature Communications

Hydrogel microparticles for biomedical applications

(2019) Andrew C. Daly et al.   Nature Reviews Materials

Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

(2019) Weidong Nie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-organic frameworks for stimuli-responsive drug delivery

(2019) Ying Wang et al.   BIOMATERIALS

An Injectable Cytokine Trap for Local Treatment of Autoimmune Disease

(2019) Colin R. Zamecnik et al.   BIOMATERIALS

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

(2019) Sarwish Rafiq et al.   Nature Reviews Clinical Oncology

A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy

(2018) Yu Mi et al.   ADVANCED MATERIALS

Advances in Biomaterials for Drug Delivery

(2018) Owen S. Fenton et al.   ADVANCED MATERIALS

Cytokine induced killer cells-assisted delivery of chlorin e6 mediated self-assembled gold nanoclusters to tumors for imaging and immuno-photodynamic therapy

(2018) Fangfang Xia et al.   BIOMATERIALS

Block Copolymer Micelles in Nanomedicine Applications

(2018) Horacio Cabral et al.   CHEMICAL REVIEWS

Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy

(2018) Chih-Sheng Chiang et al.   Nature Nanotechnology

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

(2018) Chao Wang et al.   Science Translational Medicine

Antibody-cytokine fusion proteins: Biopharmaceuticals with immunomodulatory properties for cancer therapy

(2018) Cornelia Hutmacher et al.   ADVANCED DRUG DELIVERY REVIEWS

Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC

(2018) Scott J. Antonia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multi-Stimuli-Responsive Polymer Particles, Films, and Hydrogels for Drug Delivery

(2018) Xiao Fu et al.   Chem

Tumor-Acidity-Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles To Overcome Delivery Barriers in Cancer Nanomedicine

(2018) Jin-Zhi Du et al.   ACCOUNTS OF CHEMICAL RESEARCH

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer

(2018) Feng Chen et al.   Nature Communications

Nanocarriers and Their Loading Strategies

(2018) Neng Wang et al.   Advanced Healthcare Materials

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

(2018) Quanyin Hu et al.   Nature Biomedical Engineering

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

(2017) Shuaijian Ni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microneedles-Based Transdermal Drug Delivery Systems: A Review

(2017) Ying Hao et al.   Journal of Biomedical Nanotechnology

The making of bispecific antibodies

(2017) Ulrich Brinkmann et al.   mAbs

Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies

(2017) Elie Dheilly et al.   MOLECULAR THERAPY

Next generation antibody drugs: pursuit of the 'high-hanging fruit'

(2017) Paul J. Carter et al.   NATURE REVIEWS DRUG DISCOVERY

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

(2017) Daniela Schmid et al.   Nature Communications

Recent Advances in the Generation of Antibody-Nanomaterial Conjugates

(2017) Amal J. Sivaram et al.   Advanced Healthcare Materials

The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade

(2017) Howard Y. Li et al.   Cancer Immunology Research

Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

(2017) Suping Li et al.   Nature Biomedical Engineering

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

(2016) Yanqi Ye et al.   ACS Nano

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

(2016) Meromit Singer et al.   CELL

Nanoparticles for the delivery of therapeutic antibodies: Dogma or promising strategy?

(2016) Flávia Sousa et al.   Expert Opinion on Drug Delivery

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

(2016) Muhammad Umair et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Antibody–drug conjugates for cancer therapy

(2016) Anish Thomas et al.   LANCET ONCOLOGY

Use of aptamers in immunoassays

(2016) Roald Nezlin   MOLECULAR IMMUNOLOGY

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

(2016) Quanyin Hu et al.   NANO LETTERS

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

(2016) Chao Wang et al.   NANO LETTERS

Mechanism of hard-nanomaterial clearance by the liver

(2016) Kim M. Tsoi et al.   NATURE MATERIALS

Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies

(2016) Christopher B. Howard et al.   Advanced Healthcare Materials

Bioresponsive materials

(2016) Yue Lu et al.   Nature Reviews Materials

DNA-Directed Antibody Immobilization for Enhanced Detection of Single Viral Pathogens

(2015) Elif Seymour et al.   ANALYTICAL CHEMISTRY

Identification of a peptide ligand for antibody immobilization on biosensor surfaces

(2015) Ran-Ji Yoo et al.   BioChip Journal

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages: A Potent Effector Mechanism of Monoclonal Antibody Therapy of Cancer

(2015) N. Gul et al.   CANCER RESEARCH

Biomedical applications of hydrogels: A review of patents and commercial products

(2015) Enrica Caló et al.   EUROPEAN POLYMER JOURNAL

Exosome mediated communication within the tumor microenvironment

(2015) Lara Milane et al.   JOURNAL OF CONTROLLED RELEASE

A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells

(2015) Emily C Piccione et al.   mAbs

IgG Fc-binding peptide (FcBP)-tat conjugate as a smart antibody carrier into live cells

(2015) Hyo Jin Kang et al.   MACROMOLECULAR RESEARCH

Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization

(2015) C. Chiappini et al.   NATURE MATERIALS

Hydrogels and Scaffolds for Immunomodulation

(2014) Ankur Singh et al.   ADVANCED MATERIALS

The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery

(2014) Lauren A. Austin et al.   ARCHIVES OF TOXICOLOGY

Multi-Specific Antibodies for Cancer Immunotherapy

(2014) Ron D. Jachimowicz et al.   BIODRUGS

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

(2014) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage

(2013) Amr S. Abu Lila et al.   JOURNAL OF CONTROLLED RELEASE

Approaches to improve tumor accumulation and interactions between monoclonal antibodies and immune cells

(2013) Fabrizio Marcucci et al.   mAbs

Antibody biodistribution coefficients

(2013) Dhaval K. Shah et al.   mAbs

Enhanced drug delivery via hyperthermal membrane disruption using targeted gold nanoparticles with PEGylated Protein-G as a cofactor

(2013) Xinghua Sun et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting of Primary Breast Cancers and Metastases in a Transgenic Mouse Model Using Rationally Designed Multifunctional SPIONs

(2012) Forrest M. Kievit et al.   ACS Nano

Controlled antibody/(bio-) conjugation of inorganic nanoparticles for targeted delivery

(2012) Jose-Maria Montenegro et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

(2012) Fangqiong Tang et al.   ADVANCED MATERIALS

Antibody-Conjugated Nanoparticles for Therapeutic Applications

(2012) M. M. Cardoso et al.   CURRENT MEDICINAL CHEMISTRY

Combination strategies to enhance antitumor ADCC

(2012) Holbrook E Kohrt et al.   Immunotherapy

Controlled release of Rituximab from gold nanoparticles for phototherapy of malignant cells

(2012) Gili Bisker et al.   JOURNAL OF CONTROLLED RELEASE

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Monolayer coated gold nanoparticles for delivery applications

(2011) Subinoy Rana et al.   ADVANCED DRUG DELIVERY REVIEWS

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

(2011) Barbara Molon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody Adsorption and Orientation on Hydrophobic Surfaces

(2011) Meredith E. Wiseman et al.   LANGMUIR

Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates

(2011) Tanya Stuchinskaya et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species

(2010) Xinglu Huang et al.   BIOMATERIALS

Avidin-biotin technology in targeted therapy

(2010) Hanna P Lesch et al.   Expert Opinion on Drug Delivery

Nature and Strength of M−S Bonds (M = Au, Ag, and Cu) in Binary Alloy Gold Clusters

(2010) A. H. Pakiari et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance

(2010) Hiroshi Tanaka et al.   NATURE MEDICINE

Optimizing immobilization on two-dimensional carboxyl surface: pH dependence of antibody orientation and antigen binding capacity

(2009) Zhichao Pei et al.   ANALYTICAL BIOCHEMISTRY

Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery

(2009) Shaojun Guo et al.   BIOMATERIALS

Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy

(2009) E. Martinelli et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells

(2008) Paul A. McCarron et al.   BIOCONJUGATE CHEMISTRY

Simultaneous intracellular delivery of targeting antibodies and functional nanoparticles with engineered protein G system

(2008) Yong Taik Lim et al.   BIOMATERIALS

Application of Nanotechnology in Cancer Therapy and Imaging

(2008) X. Wang et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties

(2008) S Kumar et al.   Nature Protocols