Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Is COVID-19 receiving ADE from other coronaviruses?

(2020) Jason A. Tetro   MICROBES AND INFECTION

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

(2020) Bin Zhang et al.   CHEST

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility

(2020) Jasper Fuk-Woo Chan et al.   CLINICAL INFECTIOUS DISEASES

Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019

(2020) Juanjuan Zhao et al.   CLINICAL INFECTIOUS DISEASES

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The convalescent sera option for containing COVID-19

(2020) Arturo Casadevall et al.   JOURNAL OF CLINICAL INVESTIGATION

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

(2020) Rui Shi et al.   NATURE

Human neutralizing antibodies elicited by SARS-CoV-2 infection

(2020) Bin Ju et al.   NATURE

Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

(2020) Tommy Tsan-Yuk Lam et al.   NATURE

Developing Covid-19 Vaccines at Pandemic Speed

(2020) Nicole Lurie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Against pandemic research exceptionalism

(2020) Alex John London et al.   SCIENCE

Development of an inactivated vaccine candidate for SARS-CoV-2

(2020) Qiang Gao et al.   SCIENCE

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study

(2020) Shufa Zheng et al.   BMJ-British Medical Journal

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

(2020) Kenrie P Y Hui et al.   Lancet Respiratory Medicine

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

(2020) Yunlong Cao et al.   CELL

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19

(2020) Ling Li et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Early safety indicators of COVID-19 convalescent plasma in 5000 patients

(2020) Michael J. Joyner et al.   JOURNAL OF CLINICAL INVESTIGATION

Viral dynamics in mild and severe cases of COVID-19

(2020) Yang Liu et al.   LANCET INFECTIOUS DISEASES

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

(2020) Quan-Xin Long et al.   NATURE MEDICINE

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

(2020) Philip J. M. Brouwer et al.   SCIENCE

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

A highly immunogenic, protective and safe adenovirus-based vaccine expressing MERS-CoV S1-CD40L fusion protein in transgenic human DPP4 mouse model

(2019) Anwar M Hashem et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics

(2019) Katie L. Winarski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function

(2019) Andrew R. Crowley et al.   Frontiers in Immunology

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

(2019) Yushun Wan et al.   JOURNAL OF VIROLOGY

Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience

(2018) Jae-Hoon Ko et al.   ANTIVIRAL THERAPY

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

(2018) Saranya Sridhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?

(2018) Carlos A. Sariol et al.   TRENDS IN MICROBIOLOGY

Evaluation of Antibody-Dependent Enhancement of SARS-CoV Infection in Rhesus Macaques Immunized with an Inactivated SARS-CoV Vaccine

(2018) Fan Luo et al.   VIROLOGICA SINICA

Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques

(2018) Matthew S. Parsons et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

(2017) Taia T. Wang et al.   SCIENCE

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

(2016) David J. DiLillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Vaccines against respiratory syncytial virus: The time has finally come

(2016) Barney S. Graham   VACCINE

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

(2016) Anurodh Shankar Agrawal et al.   Human Vaccines & Immunotherapeutics

Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates

(2016) Qidi Wang et al.   ACS Infectious Diseases

Influenza-Specific Antibody-Dependent Phagocytosis

(2016) Fernanda Ana-Sosa-Batiz et al.   PLoS One

Prior Immunization with Severe Acute Respiratory Syndrome (SARS)-Associated Coronavirus (SARS-CoV) Nucleocapsid Protein Causes Severe Pneumonia in Mice Infected with SARS-CoV

(2014) F. Yasui et al.   JOURNAL OF IMMUNOLOGY

The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis

(2014) John Mair-Jenkins et al.   JOURNAL OF INFECTIOUS DISEASES

Severe Acute Respiratory Syndrome-Associated Coronavirus Vaccines Formulated with Delta Inulin Adjuvants Provide Enhanced Protection while Ameliorating Lung Eosinophilic Immunopathology

(2014) Yoshikazu Honda-Okubo et al.   JOURNAL OF VIROLOGY

Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy

(2014) A. Hiatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus

(2014) Fumihiko Yasui et al.   VIROLOGY

Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus

(2014) Ming Yip et al.   Virology Journal

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

(2013) Jie Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

Adverse effects of plasma transfusion

(2012) Suchitra Pandey et al.   TRANSFUSION

Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH- and Cysteine Protease-Independent Fc R Pathway

(2011) M. Jaume et al.   JOURNAL OF VIROLOGY

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant

(2011) L. Zeitlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans

(2010) W. Dejnirattisai et al.   SCIENCE