Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation

Automated Transition State Search and Its Application to Diverse Types of Organic Reactions

(2017) Leif D. Jacobson et al.   Journal of Chemical Theory and Computation

Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody–drug conjugates

(2017) Feng Tang et al.   Nature Protocols

Current Status: Site-Specific Antibody Drug Conjugates

(2016) Dominik Schumacher et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Covalent Chemical Ligation Strategy for Mono- and Polyclonal Immunoglobulins at Their Nucleotide Binding Sites

(2015) Diana Lac et al.   BIOCONJUGATE CHEMISTRY

Antibody Conjugates with Unnatural Amino Acids

(2015) Trevor J. Hallam et al.   MOLECULAR PHARMACEUTICS

π-Clamp-mediated cysteine conjugation

(2015) Chi Zhang et al.   Nature Chemistry

Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics

(2015) Violette Gautier et al.   PROTEOMICS

Hydroprocessing of Jatropha Oil for Production of Green Diesel over Non-sulfided Ni-PTA/Al2O3 Catalyst

(2015) Jing Liu et al.   Scientific Reports

Protein and antibody functionalization using continuous flow microreactor technology

(2015) Meaghan M. Sebeika et al.   Journal of Flow Chemistry

Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency

(2015) Roger R. Beerli et al.   PLoS One

Cross-strand histidine–aromatic interactions enhance acyl-transfer rates in beta-hairpin peptide catalysts

(2014) M. Matsumoto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

SITE-SPECIFIC LABELING OF A PROTEIN LYSINE RESIDUE BY NOVEL KINETIC LABELING COMBINATORIAL LIBRARIES

(2014) Allen Krantz et al.   Computational and Structural Biotechnology Journal

Site-Selective Lysine Modification of Native Proteins and Peptides via Kinetically Controlled Labeling

(2012) Xi Chen et al.   BIOCONJUGATE CHEMISTRY

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Protein Chemical Modification on Endogenous Amino Acids

(2010) Emmanuel Baslé et al.   CHEMISTRY & BIOLOGY

Direct Observation of an Enamine Intermediate in Amine Catalysis

(2009) Xueyong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY