LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

(2020) Marı́a Maneiro et al.   ACS Chemical Biology

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Targeted glycan degradation potentiates the anticancer immune response in vivo

(2020) Melissa A. Gray et al.   Nature Chemical Biology

Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence

(2019) Ji-Hua Shi et al.   Cancer Medicine

Interactive Peptide Spectral Annotator: A Versatile Web-Based Tool for Proteomic Applications

(2019) Dain R. Brademan et al.   MOLECULAR & CELLULAR PROTEOMICS

ATTEC: a potential new approach to target proteinopathies

(2019) Zhaoyang Li et al.   Autophagy

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

Targeted protein degradation: expanding the toolbox

(2019) Matthieu Schapira et al.   NATURE REVIEWS DRUG DISCOVERY

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

Enhanced Global Post-translational Modification Discovery with MetaMorpheus

(2018) Stefan K. Solntsev et al.   JOURNAL OF PROTEOME RESEARCH

The dTAG system for immediate and target-specific protein degradation

(2018) Behnam Nabet et al.   Nature Chemical Biology

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

(2017) Byron H. Kwan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

(2017) Tracy S. Zimmermann et al.   MOLECULAR THERAPY

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

(2017) Kevin Fitzgerald et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation

(2016) Nick Cox et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Well-Defined Multivalent Ligands for Hepatocytes Targeting via Asialoglycoprotein Receptor

(2016) Xiangang Huang et al.   BIOCONJUGATE CHEMISTRY

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

A Calibration Routine for Efficient ETD in Large-Scale Proteomics

(2015) Christopher M. Rose et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

(2014) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

OPN and αvβ3 Expression are Predictors of Disease Severity and Worse Prognosis in Hepatocellular Carcinoma

(2014) Yi Jin et al.   PLoS One

Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates

(2013) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

(2013) G. Lu et al.   SCIENCE

EGFR activation is a potential determinant of primary resistance of hepatocellular carcinoma cells to sorafenib

(2012) Zakaria Ezzoukhry et al.   INTERNATIONAL JOURNAL OF CANCER

Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells

(2012) Marie-José Blivet-Van Eggelpoël et al.   JOURNAL OF HEPATOLOGY

Site-specific chemical protein conjugation using genetically encoded aldehyde tags

(2012) David Rabuka et al.   Nature Protocols

CD22 Is a Recycling Receptor That Can Shuttle Cargo between the Cell Surface and Endosomal Compartments of B Cells

(2010) M. K. O'Reilly et al.   JOURNAL OF IMMUNOLOGY

Engineered cystine knot peptides that bind αvβ3, αvβ5, and α5β1 integrins with low-nanomolar affinity

(2009) Richard H. Kimura et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS