Therapeutic Antibodies against Intracellular Tumor Antigens

A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens

(2017) Aaron Y. Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

(2017) Seung-Min Shin et al.   Nature Communications

A meta-analysis of HLA peptidome composition in different hematological entities: entity-specific dividing lines and "pan-leukemia" antigens

(2017) Linus Backert et al.   Oncotarget

Engineering chimeric human and mouse major histocompatibility complex (MHC) class I tetramers for the production of T-cell receptor (TCR) mimic antibodies

(2017) Demin Li et al.   PLoS One

Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics

(2016) Niloufar Ataie et al.   JOURNAL OF MOLECULAR BIOLOGY

Production and clinical development of nanoparticles for gene delivery

(2016) Jie Chen et al.   Molecular Therapy-Methods & Clinical Development

Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm?

(2016) Andrea L.J. Marschall et al.   Computational and Structural Biotechnology Journal

Confocal Imaging–Guided Laser Ablation of Basal Cell Carcinomas: An Ex Vivo Study

(2015) Heidy Sierra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential

(2015) Q Zhao et al.   LEUKEMIA

Specificin vivoknockdown of protein function by intrabodies

(2015) Andrea LJ Marschall et al.   mAbs

Macrophages are critical effectors of antibody therapies for cancer

(2015) Kipp Weiskopf et al.   mAbs

Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation

(2015) Michal Bassani-Sternberg et al.   MOLECULAR & CELLULAR PROTEOMICS

ImmTACs for targeted cancer therapy: Why, what, how, and which

(2015) Joanne Oates et al.   MOLECULAR IMMUNOLOGY

Liposome-based Formulation for Intracellular Delivery of Functional Proteins

(2015) Benoît Chatin et al.   Molecular Therapy-Nucleic Acids

T cell receptor mimic antibodies for cancer therapy

(2015) Leonid Dubrovsky et al.   OncoImmunology

Engineering the First Chimeric Antibody in Targeting Intracellular PRL-3 Oncoprotein for Cancer Therapy in Mice

(2015) Ke Guo et al.   Oncotarget

A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias

(2014) L. Dubrovsky et al.   BLOOD

MHC Class I Loss Is a Frequent Mechanism of Immune Escape in Papillary Thyroid Cancer That Is Reversed by Interferon and Selumetinib Treatment In Vitro

(2014) T. E. Angell et al.   CLINICAL CANCER RESEARCH

Construction and molecular characterization of a T-cell receptor-like antibody and CAR-T cells specific for minor histocompatibility antigen HA-1H

(2014) Y Inaguma et al.   GENE THERAPY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Survivin-specific T cell receptor targets tumor but not T cells

(2014) Caroline Arber et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Comparison of Engineered T Cells Carrying a Native TCR versus TCR-like Antibody–Based Chimeric Antigen Receptors Indicates Affinity/Avidity Thresholds

(2014) Ravit Oren et al.   JOURNAL OF IMMUNOLOGY

Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor

(2014) Ge Zhang et al.   Scientific Reports

Ligand-targeted liposome design: challenges and fundamental considerations

(2013) Gavin T. Noble et al.   TRENDS IN BIOTECHNOLOGY

Targeting protein–protein interactions as an anticancer strategy

(2013) Andrei A. Ivanov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Formation strategies, mechanism of intracellular delivery and potential clinical applications of pH-sensitive liposomes

(2013) Xin Liu et al.   Asian Journal of Pharmaceutical Sciences

Suppression, subversion and escape: the role of regulatory T cells in cancer progression

(2012) K. Oleinika et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

T-cell-receptor-like antibodies – generation, function and applications

(2012) Rony Dahan et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

PLGA-based nanoparticles: An overview of biomedical applications

(2012) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells

(2011) A. Sergeeva et al.   BLOOD

TCR-like Biomolecules Target Peptide/MHC Class I Complexes on the Surface of Infected and Cancerous Cells

(2011) Jon A. Weidanz et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

TCR Mimic Monoclonal Antibodies Induce Apoptosis of Tumor Cells via Immune Effector-Independent Mechanisms

(2011) B. Verma et al.   JOURNAL OF IMMUNOLOGY

An HLA-Presented Fragment of Macrophage Migration Inhibitory Factor Is a Therapeutic Target for Invasive Breast Cancer

(2011) O. Hawkins et al.   JOURNAL OF IMMUNOLOGY

Targeting Intracellular Oncoproteins with Antibody Therapy or Vaccination

(2011) K. Guo et al.   Science Translational Medicine

Intracellular antibodies and cancer: New technologies offer therapeutic opportunities

(2010) David Pérez-Martínez et al.   BIOESSAYS

Direct visualization of the dynamics of antigen presentation in human cells infected with cytomegalovirus revealed by antibodies mimicking TCR specificity

(2010) Oryan Makler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A census of predicted mutational epitopes suitable for immunologic cancer control

(2010) René L. Warren et al.   HUMAN IMMUNOLOGY

Technologies for MHC class I immunoproteomics

(2010) Rieuwert Hoppes et al.   Journal of Proteomics

Targeting Hepatitis B Virus-Infected Cells with a T-Cell Receptor-Like Antibody

(2010) K. S. R. Sastry et al.   JOURNAL OF VIROLOGY

Interfering with RAS–effector protein interactions prevent RAS-dependent tumour initiation and causes stop–start control of cancer growth

(2010) T Tanaka et al.   ONCOGENE

Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment

(2009) Ayman El-Sayed et al.   AAPS Journal

Recent advances in the use of cell-penetrating peptides for medical and biological applications☆

(2009) Sonali B. Fonseca et al.   ADVANCED DRUG DELIVERY REVIEWS

Direct discovery and validation of a peptide/MHC epitope expressed in primary human breast cancer cells using a TCRm monoclonal antibody with profound antitumor properties

(2009) Bhavna Verma et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Expression Hierarchy of T Cell Epitopes from Melanoma Differentiation Antigens: Unexpected High Level Presentation of Tyrosinase-HLA-A2 Complexes Revealed by Peptide-Specific, MHC-Restricted, TCR-Like Antibodies

(2009) Yael Michaeli et al.   JOURNAL OF IMMUNOLOGY

Erratum: Mechanisms of regulated unconventional protein secretion

(2009) Walter Nickel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Correction for Stewart-Jones et al., Rational development of high-affinity T-cell receptor-like antibodies

(2009)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammatory Response to Cell Death

(2008) Kenneth L. Rock et al.   Annual Review of Pathology-Mechanisms of Disease

PRL PTPs: mediators and markers of cancer progression

(2008) Darrell C. Bessette et al.   CANCER AND METASTASIS REVIEWS

Antitumor Activity of Immunotoxins with T-Cell Receptor-like Specificity against Human Melanoma Xenografts

(2008) E. Klechevsky et al.   CANCER RESEARCH

Optimized stability retention of a monoclonal antibody in the PLGA nanoparticles

(2008) Sejin Son et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

How a T Cell Receptor-like Antibody Recognizes Major Histocompatibility Complex-bound Peptide

(2008) Tatiana Mareeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessing vaccine potency using TCRmimic antibodies

(2008) Francisca A. Neethling et al.   VACCINE

Functional Intracellular Antibody Fragments Do Not Require Invariant Intra-domain Disulfide Bonds

(2007) Tomoyuki Tanaka et al.   JOURNAL OF MOLECULAR BIOLOGY