Types of nuclear localization signals and mechanisms of protein import into the nucleus

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression

(2020) Abiola Abdulrahman Ayanlaja et al.   Cell Communication and Signaling

Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha

(2020) Natália E. Bernardes et al.   Scientific Reports

C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

(2020) Lindsey R Hayes et al.   eLife

Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis

(2020) Gaoxingyu Huang et al.   CELL RESEARCH

Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex

(2020) Yanqing Zhang et al.   CELL RESEARCH

Nuclear import of NLS- RARα is mediated by importin α/β

(2020) Jiao Ye et al.   CELLULAR SIGNALLING

SUMOylation Is Required for ERK5 Nuclear Translocation and ERK5-Mediated Cancer Cell Proliferation

(2020) Tatiana Erazo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of mRNA export through API5 and nuclear FGF2 interaction

(2020) Seoung Min Bong et al.   NUCLEIC ACIDS RESEARCH

Dissecting the Roles of Cse1 and Nup2 in Classical NLS‐Cargo Release in vivo

(2020) Allison Lange et al.   TRAFFIC

Phosphorylation within the bipartite NLS alters the localization and toxicity of the ER stress response factor DDIT3/CHOP

(2020) Jonathan C. Bartko et al.   CELLULAR SIGNALLING

Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions

(2020) Saskia Hutten et al.   Cell Reports

Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-α

(2019) Yoshiyuki Matsuura   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells

(2019) Jai-Hong Cheng et al.   Virology Journal

Development of a novel DsRed-NLS vector with a monopartite classical nuclear localization signal

(2019) Hee Sang You et al.   3 Biotech

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

(2019) Sinan Kilic et al.   EMBO JOURNAL

Competitive inhibition by NAG-1/GDF-15 NLS peptide enhances its anti-cancer activity

(2019) Jaehak Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of the Importin-β binding domain in nuclear import receptor KPNA7

(2019) Luke T. Oostdyk et al.   BIOCHEMICAL JOURNAL

Mechanisms Mediating Nuclear Trafficking Involved in Viral Propagation by DNA Viruses

(2019) Guohui Li et al.   Viruses-Basel

Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation

(2019) Shotaro Yamano et al.   EXPERIMENTAL CELL RESEARCH

IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers

(2019) Monika Mis et al.   JOURNAL OF CELL BIOLOGY

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

(2018) Mario Hofweber et al.   CELL

The Rules and Functions of Nucleocytoplasmic Shuttling Proteins

(2018) Xuekun Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Piwi Nuclear Localization and Its Regulatory Mechanism in Drosophila Ovarian Somatic Cells

(2018) Ryu Yashiro et al.   Cell Reports

Oligohistidine and targeting peptide functionalized TAT-NLS for enhancing cellular uptake and promoting angiogenesis in vivo

(2018) Qian Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

Importin α: functions as a nuclear transport factor and beyond

(2018) Masahiro OKA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2

(2018) Matthew J. Lyst et al.   Cell Reports

Karyopherins regulate nuclear pore complex barrier and transport function

(2017) Larisa E. Kapinos et al.   JOURNAL OF CELL BIOLOGY

TP53 and 53BP1 Reunited

(2017) Thierry Soussi et al.   TRENDS IN CELL BIOLOGY

The role of nuclear localization signal in parvovirus life cycle

(2017) Peng Liu et al.   Virology Journal

Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1

(2017) Rajeshwer S. Sankhala et al.   Nature Communications

Extensive cargo identification reveals distinct biological roles of the 12 importin pathways

(2017) Makoto Kimura et al.   eLife

Identification of nuclear localization signals in the human homeoprotein MSX1

(2017) Akio Shibata et al.   Biochemistry and Cell Biology

Nuclear localization signal sequence is required for VACM-1/CUL5-dependent regulation of cellular growth

(2016) Angelica N. Willis et al.   CELL AND TISSUE RESEARCH

Importin α: a key molecule in nuclear transport and non-transport functions

(2016) Yoichi Miyamoto et al.   JOURNAL OF BIOCHEMISTRY

The nuclear pore complex: understanding its function through structural insight

(2016) Martin Beck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Super-resolution 3D tomography of interactions and competition in the nuclear pore complex

(2016) Jiong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

(2016) Sergio P. Acebron et al.   TRENDS IN CELL BIOLOGY

Super-resolution 3D tomography of interactions and competition in the nuclear pore complex

(2016) Jiong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nucleocytoplasmic transport inC9orf72-mediated ALS/FTD

(2016) Ke Zhang et al.   Nucleus

Nucleocytoplasmic transport inC9orf72-mediated ALS/FTD

(2016) Ke Zhang et al.   Nucleus

Efficient and dynamic nuclear localization of green fluorescent protein via RNA binding

(2015) Akira Kitamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation Controls the Nuclear-Cytoplasmic Shuttling of Influenza A Virus Nucleoprotein

(2015) Weinan Zheng et al.   JOURNAL OF VIROLOGY

Nucleocytoplasmic Shuttling of Influenza A Virus Proteins

(2015) Jing Li et al.   Viruses-Basel

Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

(2015) Alan R Lowe et al.   eLife

Components and regulation of nuclear transport processes

(2014) Bastien Cautain et al.   FEBS Journal

Transportin-1 and Transportin-2: Protein nuclear import and beyond

(2014) Laure Twyffels et al.   FEBS LETTERS

WITHDRAWN: The hydrophobic rich N- and C-terminal tails of beta-catenin facilitate nuclear import of beta-catenin

(2014) Manisha Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beta-Like Importins Mediate the Nuclear Translocation of Mitogen-Activated Protein Kinases

(2013) E. Zehorai et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure-function relationship of the nuclear localization signal sequence of parathyroid hormone-related protein

(2012) Keiichic Ohshima et al.   BIOMEDICAL RESEARCH-TOKYO

A PY-nuclear localization signal is required for nuclear accumulation of HCMV UL79 protein

(2012) Lin Wang et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

A Proline-Tyrosine Nuclear Localization Signal (PY-NLS) Is Required for the Nuclear Import of Fission Yeast PAB2, but Not of Human PABPN1

(2012) Pierre-Luc Mallet et al.   TRAFFIC

Specific Armadillo Repeat Sequences Facilitate β-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358

(2011) Manisha Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The importin β binding domain as a master regulator of nucleocytoplasmic transport

(2010) Kaylen Lott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear import by karyopherin-βs: Recognition and inhibition

(2010) Yuh Min Chook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The nuclear pore complex: bridging nuclear transport and gene regulation

(2010) Caterina Strambio-De-Castillia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NLStradamus: a simple Hidden Markov Model for nuclear localization signal prediction

(2009) Alex N Nguyen Ba et al.   BMC BIOINFORMATICS

Strong expression of chemokine receptor CXCR4 by renal cell carcinoma cells correlates with metastasis

(2009) Linhui Wang et al.   CLINICAL & EXPERIMENTAL METASTASIS

Flexible Gates: Dynamic Topologies and Functions for FG Nucleoporins in Nucleocytoplasmic Transport

(2009) Laura J. Terry et al.   EUKARYOTIC CELL

The Nuclear Pore Complex Has Entered the Atomic Age

(2009) Stephen G. Brohawn et al.   STRUCTURE

A PY-NLS Nuclear Targeting Signal Is Required for Nuclear Localization and Function of theSaccharomyces cerevisiaemRNA-binding Protein Hrp1

(2008) Allison Lange et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importin-β: Structural and Dynamic Determinants of a Molecular Spring

(2008) Ulrich Zachariae et al.   STRUCTURE

Probing Intranuclear Environments at the Single-Molecule Level

(2007) David Grünwald et al.   BIOPHYSICAL JOURNAL