Targeting the N terminus for site-selective protein modification

Capture and Recycling of Sortase A through Site-Specific Labeling with Lithocholic Acid

(2016) Christian B. Rosen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-terminal specific conjugation of extracellular matrix proteins to 2-pyridinecarboxaldehyde functionalized polyacrylamide hydrogels

(2016) Jessica P. Lee et al.   BIOMATERIALS

New developments for antibody-drug conjugate-based therapeutic approaches

(2016) Bart ECG de Goeij et al.   CURRENT OPINION IN IMMUNOLOGY

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

(2016) Peter L. Turecek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In Vivo Site-Specific Protein Tagging with Diverse Amines Using an Engineered Sortase Variant

(2016) Jeff E. Glasgow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-selective incorporation and ligation of protein aldehydes

(2016) Richard J. Spears et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fast and selective labeling of N-terminal cysteines at neutral pH via thiazolidino boronate formation

(2016) Anupam Bandyopadhyay et al.   Chemical Science

Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation

(2016) Hélio Faustino et al.   Chemical Science

Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry

(2015) Paresh Agarwal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific N-Terminal Labeling of Peptides and Proteins using Butelase 1 and Thiodepsipeptide

(2015) Giang K. T. Nguyen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sortase A-Mediated N-Terminal Modification of Cowpea Chlorotic Mottle Virus for Highly Efficient Cargo Loading

(2015) Lise Schoonen et al.   BIOCONJUGATE CHEMISTRY

Conjugation of PolyPEG to Interferon Alpha Extends Serum Half-Life while Maintaining Low Viscosity of the Conjugate

(2015) B. Podobnik et al.   BIOCONJUGATE CHEMISTRY

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Site-Specific PEGylation of Therapeutic Proteins

(2015) Jonathan Dozier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Optimization and Expansion of a Site-Selective N-Methylpyridinium-4-carboxaldehyde-Mediated Transamination for Bacterially Expressed Proteins

(2015) Kanwal S. Palla et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aldehyde Capture Ligation for Synthesis of Native Peptide Bonds

(2015) Monika Raj et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging and manipulating proteins in live cells through covalent labeling

(2015) Lin Xue et al.   Nature Chemical Biology

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

(2015) James I MacDonald et al.   Nature Chemical Biology

Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins

(2015) Yael David et al.   Nature Chemistry

Selective, rapid and optically switchable regulation of protein function in live mammalian cells

(2015) Yu-Hsuan Tsai et al.   Nature Chemistry

Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

(2015) Estela Haldón et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects

(2015) Sylvia Varland et al.   PROTEOMICS

A peptide N-terminal protection strategy for comprehensive glycoproteome analysis using hydrazide chemistry based method

(2015) Junfeng Huang et al.   Scientific Reports

2013 Statistics for Global Prescription Medications: CNS Therapeutics Maintain a Leading Position among Small Molecule Therapeutics

(2014) Craig W. Lindsley   ACS Chemical Neuroscience

N-Terminal Modification of Proteins with o-Aminophenols

(2014) Allie C. Obermeyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

(2014) Giang K T Nguyen et al.   Nature Chemical Biology

Site-Specific Chemoenzymatic Labeling of Aerolysin Enables the Identification of New Aerolysin Receptors

(2014) Irene Wuethrich et al.   PLoS One

Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling

(2014) A. P. Wiita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Terminal Labeling of Peptides by Trypsin-Catalyzed Ligation for Quantitative Proteomics

(2013) Yanbo Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Imaging of Cancer Cells Using a Bacteriophage-Based129Xe NMR Biosensor

(2013) Krishnan K. Palaniappan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced Catalysis of Oxime-Based Bioconjugations by Substituted Anilines

(2013) Michaela Wendeler et al.   BIOCONJUGATE CHEMISTRY

Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches

(2013) Wiktor Szymański et al.   CHEMICAL REVIEWS

Site-Specific Protein Transamination Using N-Methylpyridinium-4-carboxaldehyde

(2013) Leah S. Witus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Labeling Proteins with Fluorophore/Thioamide Förster Resonant Energy Transfer Pairs by Combining Unnatural Amino Acid Mutagenesis and Native Chemical Ligation

(2013) Rebecca F. Wissner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific N-terminal labeling of proteins using sortase-mediated reactions

(2013) Christopher S Theile et al.   Nature Protocols

Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions

(2013) Carla P Guimaraes et al.   Nature Protocols

Mutant methionyl-tRNA synthetase from bacteria enables site-selective N-terminal labeling of proteins expressed in mammalian cells

(2013) J. T. Ngo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythropoietin Derived by Chemical Synthesis

(2013) P. Wang et al.   SCIENCE

N-Terminal Labeling of Filamentous Phage To Create Cancer Marker Imaging Agents

(2012) Zachary M. Carrico et al.   ACS Nano

Efficient N-Terminal Labeling of Proteins by Use of Sortase

(2012) Daniel J. Williamson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Method for Site-Specific 18F-Labeling of Biomolecules Using the Rapid Condensation Reaction between 2-Cyanobenzothiazole and Cysteine

(2012) Jongho Jeon et al.   BIOCONJUGATE CHEMISTRY

Modification of N-Terminal α-Amino Groups of Peptides and Proteins Using Ketenes

(2012) Anna On-Yee Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recyclable Thermoresponsive Polymer–Cellulase Bioconjugates for Biomass Depolymerization

(2012) Katherine J. Mackenzie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Detection by Nanopores Equipped with Aptamers

(2012) Dvir Rotem et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR

(2012) S. A. Kazane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetically modified Fc domains as building blocks for immunotherapy applications

(2012) Chawita Netirojjanakul et al.   Chemical Science

Making and Breaking Peptide Bonds: Protein Engineering Using Sortase

(2011) Maximilian Wei-Lin Popp et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioconjugation via azide–Staudinger ligation: an overview

(2011) Christine I. Schilling et al.   CHEMICAL SOCIETY REVIEWS

Genetically Encoded 1,2-Aminothiols Facilitate Rapid and Site-Specific Protein Labeling via a Bio-orthogonal Cyanobenzothiazole Condensation

(2011) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry

(2011) William P Heal et al.   Nature Protocols

Metal-free and pH-controlled introduction of azides in proteins

(2011) Sanne Schoffelen et al.   Chemical Science

Site-selective dual modification of periplasmic binding proteins for sensing applications

(2010) Amanda P. Crochet et al.   BIOSENSORS & BIOELECTRONICS

Protein Chemical Modification on Endogenous Amino Acids

(2010) Emmanuel Baslé et al.   CHEMISTRY & BIOLOGY

Identification of Highly Reactive Sequences For PLP-Mediated Bioconjugation Using a Combinatorial Peptide Library

(2010) Leah S. Witus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

(2009) Hongjun Ren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sortase-Mediated Ligation: A Gift from Gram-Positive Bacteria to Protein Engineering

(2009) Shinya Tsukiji et al.   CHEMBIOCHEM

Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity

(2009) John M. Antos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters

(2009) Guillaume Charron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoscale Protein Assemblies from a Circular Permutant of the Tobacco Mosaic Virus

(2009) Michel T. Dedeo et al.   NANO LETTERS

A biocompatible condensation reaction for controlled assembly of nanostructures in living cells

(2009) Gaolin Liang et al.   Nature Chemistry

Protein-Cross-Linked Polymeric Materials through Site-Selective Bioconjugation

(2008) Aaron P. Esser-Kahn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrolytic Stability of Hydrazones and Oximes

(2008) Jeet Kalia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini

(2008) Sami Mahrus et al.   CELL

Specific N-terminal protein labelling: use of FMDV 3Cpro protease and native chemical ligation

(2008) Gillian K. Busch et al.   CHEMICAL COMMUNICATIONS

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Metallothionein-Cross-Linked Hydrogels for the Selective Removal of Heavy Metals from Water

(2008) Aaron P. Esser-Kahn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase

(2007) Angelo Fontana et al.   ADVANCED DRUG DELIVERY REVIEWS