Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Two-Stage Strategy for Development of Proteolysis Targeting Chimeras and its Application for Estrogen Receptor Degraders

(2020) Brett L. Roberts et al.   ACS Chemical Biology

Chemical Synthesis and Biological Application of Modified Oligonucleotides

(2020) Daniel A. Glazier et al.   BIOCONJUGATE CHEMISTRY

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor

(2019) Elise Bouffard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of selective small molecule MDM2 degraders based on nutlin

(2019) Bo Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeted protein degradation: expanding the toolbox

(2019) Matthieu Schapira et al.   NATURE REVIEWS DRUG DISCOVERY

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

Development of the first small molecule histone deacetylase 6 (HDAC6) degraders

(2018) Ka Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chiral reagents in glycosylation and modification of carbohydrates

(2018) Hao-Yuan Wang et al.   CHEMICAL SOCIETY REVIEWS

Efficient therapy for refractory Pompe disease by mannose 6-phosphate analogue grafting on acid α-glucosidase

(2018) Ilaria Basile et al.   JOURNAL OF CONTROLLED RELEASE

Recent advances in site-selective functionalization of carbohydrates mediated by organocatalysts

(2018) Stephanie A. Blaszczyk et al.   CARBOHYDRATE RESEARCH

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

(2017) Karsten Schmidt et al.   NUCLEIC ACIDS RESEARCH

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

(2016) Vipul Agarwal et al.   CHEMICAL COMMUNICATIONS

Controlled Synthesis of End-Functionalized Mannose-6-phosphate Glycopolypeptides for Lysosome Targeting

(2016) Soumen Das et al.   ACS Macro Letters

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration

(2014) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

(2014) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

Liposomes containing mannose-6-phosphate-cholesteryl conjugates for lysosome-specific delivery

(2014) E. Crucianelli et al.   RSC Advances

Liver-targeting of primaquine-(poly-γ-glutamic acid) and its degradation in rat hepatocytes

(2013) Noboru Tomiya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Comprehensive Mathematical Model for Three-Body Binding Equilibria

(2013) Eugene F. Douglass et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Endocytosis and autophagy: Shared machinery for degradation

(2012) Christopher A. Lamb et al.   BIOESSAYS

N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers

(2011) Scott H. Medina et al.   BIOMATERIALS