Antibody or Antibody Fragments: Implications for Molecular Imaging and Targeted Therapy of Solid Tumors

Rapid Visualization of Human Tumor Xenografts through Optical Imaging with a Near-Infrared Fluorescent Anti–Epidermal Growth Factor Receptor Nanobody

(2018) Sabrina Oliveira et al.   Molecular Imaging

Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins

(2017) Cátia Cantante et al.   JOURNAL OF BIOTECHNOLOGY

Half-life extended biotherapeutics

(2016) Roland E. Kontermann   EXPERT OPINION ON BIOLOGICAL THERAPY

EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

(2016) Pieter B.A.A. van Driel et al.   JOURNAL OF CONTROLLED RELEASE

Human Serum Albumin and HER2-Binding Affibody Fusion Proteins for Targeted Delivery of Fatty Acid-Modified Molecules and Therapy

(2016) Daoyuan Dong et al.   MOLECULAR PHARMACEUTICS

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

(2015) Hiroshi Maeda   ADVANCED DRUG DELIVERY REVIEWS

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

(2015) Andreas Plückthun   Annual Review of Pharmacology and Toxicology

Alternative molecular formats and therapeutic applications for bispecific antibodies

(2015) Christoph Spiess et al.   MOLECULAR IMMUNOLOGY

Design considerations for nanotherapeutics in oncology

(2015) Triantafyllos Stylianopoulos et al.   Nanomedicine-Nanotechnology Biology and Medicine

A spectrophotometer-based diffusivity assay reveals that diffusion hindrance of small molecules in extracellular matrix gels used in 3D cultures is dominated by viscous effects

(2014) Roland Galgoczy et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Bispecific antibody platforms for cancer immunotherapy

(2014) Roeland Lameris et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls

(2014) Hideaki Nakamura et al.   Expert Opinion on Drug Delivery

Rapid optical imaging of human breast tumour xenografts using anti-HER2 VHHs site-directly conjugated to IRDye 800CW for image-guided surgery

(2013) Marta Kijanka et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Single-chain Variable Fragment Albumin Fusions Bind the Neonatal Fc Receptor (FcRn) in a Species-dependent Manner

(2013) Jan Terje Andersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocytosis of EGFR requires its kinase activity and N-terminal transmembrane dimerization motif

(2013) R. Heukers et al.   JOURNAL OF CELL SCIENCE

Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib

(2012) Rama H Grantab et al.   BMC CANCER

Odyssey of a cancer nanoparticle: From injection site to site of action

(2012) Joseph W. Nichols et al.   Nano Today

A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth

(2011) Rob C. Roovers et al.   INTERNATIONAL JOURNAL OF CANCER

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy

(2011) Xinran Xiang et al.   PLoS One

Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice

(2010) Lea Olive Tchouate Gainkam et al.   Contrast Media & Molecular Imaging

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein

(2010) J. Hopp et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

(2009) M. M. Schmidt et al.   MOLECULAR CANCER THERAPEUTICS

Development trends for therapeutic antibody fragments

(2009) Aaron L Nelson et al.   NATURE BIOTECHNOLOGY

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

(2008) Greg M. Thurber et al.   ADVANCED DRUG DELIVERY REVIEWS

Quantitative Spatiotemporal Analysis of Antibody Fragment Diffusion and Endocytic Consumption in Tumor Spheroids

(2008) G. M. Thurber et al.   CANCER RESEARCH

Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

(2008) B. M. Tijink et al.   MOLECULAR CANCER THERAPEUTICS

Factors determining antibody distribution in tumors

(2008) G THURBER et al.   TRENDS IN PHARMACOLOGICAL SCIENCES