Development and application of bond cleavage reactions in bioorthogonal chemistry

Second Generation TQ-Ligation for Cell Organelle Imaging

(2015) Xiaoyun Zhang et al.   ACS Chemical Biology

A rapid response “Turn-On” fluorescent probe for nitroreductase detection and its application in hypoxic tumor cell imaging

(2015) Jian Xu et al.   ANALYST

Bioorthogonal Enzymatic Activation of Caged Compounds

(2015) Cornelia Ritter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation

(2015) Joanna B. Pawlak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Bioorthogonal Reaction ofN-Oxide and Boron Reagents

(2015) Justin Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Remodeling of Cell-Surface Sialic Acids through a Palladium-Triggered Bioorthogonal Elimination Reaction

(2015) Jie Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

(2015) Jungeun Bae et al.   CHEMICAL COMMUNICATIONS

Illuminating biological processes through site-specific protein labeling

(2015) Gong Zhang et al.   CHEMICAL SOCIETY REVIEWS

Transition-metal-mediated uncaging in living human cells—an emerging alternative to photolabile protecting groups

(2015) Timo Völker et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

(2015) Gulen Yesilbag Tonga et al.   Nature Chemistry

Biomolecule-compatible chemical bond-formation and bond-cleavage reactions induced by visible light

(2015) Chenchen Hu et al.   TETRAHEDRON LETTERS

Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition

(2015) Siddharth S. Matikonda et al.   Chemical Science

Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy

(2015) Jason T. Weiss et al.   Scientific Reports

Optical Control of Protein Function through Unnatural Amino Acid Mutagenesis and Other Optogenetic Approaches

(2014) Austin S. Baker et al.   ACS Chemical Biology

Bioorthogonal Reactions for Labeling Proteins

(2014) Kathrin Lang et al.   ACS Chemical Biology

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

From the Human Genome to the Human Proteome

(2014) Javier Muñoz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Progress towards Bioorthogonal Catalysis with Organometallic Compounds

(2014) Timo Völker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Minimal Tags for Rapid Dual-Color Live-Cell Labeling and Super-Resolution Microscopy

(2014) Ivana Nikić et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanding and Reprogramming the Genetic Code of Cells and Animals

(2014) Jason W. Chin   Annual Review of Biochemistry

Pyrrolysyl-tRNA synthetase: An ordinary enzyme but an outstanding genetic code expansion tool

(2014) Wei Wan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Transition metal-mediated bioorthogonal protein chemistry in living cells

(2014) Maiyun Yang et al.   CHEMICAL SOCIETY REVIEWS

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

(2014) Craig S. McKay et al.   CHEMISTRY & BIOLOGY

Chemical Biology Strategies for Posttranslational Control of Protein Function

(2014) Rishi Rakhit et al.   CHEMISTRY & BIOLOGY

Palladium-mediated chemistry in living cells

(2014) Sunay V Chankeshwara et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine

(2014) Jason T. Weiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Concerted, Rapid, Quantitative, and Site-Specific Dual Labeling of Proteins

(2014) Amit Sachdeva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissecting motility signaling through activation of specific Src-effector complexes

(2014) Andrei V Karginov et al.   Nature Chemical Biology

Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells

(2014) Jie Li et al.   Nature Chemical Biology

Palladium-triggered deprotection chemistry for protein activation in living cells

(2014) Jie Li et al.   Nature Chemistry

A fluorescent off–on NBD-probe for F− sensing: theoretical validation and experimental studies

(2014) Arundhati Roy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms

(2014) P.-H. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioorthogonal chemistry in living organisms

(2014) Annika Borrmann et al.   Chemical Science

Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coli

(2014) Maiyun Yang et al.   Nature Communications

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

(2014) Jason T. Weiss et al.   Nature Communications

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Relative Performance of Alkynes in Copper-Catalyzed Azide–Alkyne Cycloaddition

(2013) Alexander A. Kislukhin et al.   BIOCONJUGATE CHEMISTRY

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Click Chemistry for Drug Development and Diverse Chemical–Biology Applications

(2013) Prakasam Thirumurugan et al.   CHEMICAL REVIEWS

trans-Cyclooctene—a stable, voracious dienophile for bioorthogonal labeling

(2013) Ramajeyam Selvaraj et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ligand-Free Palladium-Mediated Site-Specific Protein Labeling Inside Gram-Negative Bacterial Pathogens

(2013) Jie Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Bioorthogonal Ligation Enabled by Click Cycloaddition of o-Quinolinone Quinone Methide and Vinyl Thioether

(2013) Qiang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Water-Soluble, Donor-Acceptor Biphenyl Derivatives in the 2-(o-Nitrophenyl)propyl Series: Highly Efficient Two-Photon Uncaging of the Neurotransmitter γ-Aminobutyric Acid at λ=800 nm

(2012) Loïc Donato et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A fluorescent probe for rapid aqueous fluoride detection and cell imaging

(2012) Bowen Ke et al.   CHEMICAL COMMUNICATIONS

Metal complex catalysis in living biological systems

(2012) Pijus K. Sasmal et al.   CHEMICAL COMMUNICATIONS

Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy

(2012) Petr Klán et al.   CHEMICAL REVIEWS

Reaction-based small-molecule fluorescent probes for chemoselective bioimaging

(2012) Jefferson Chan et al.   Nature Chemistry

Direct protein control

(2012) Monya Baker   NATURE METHODS

Selective esterase-ester pair for targeting small molecules with cellular specificity

(2012) L. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioconjugation with Strained Alkenes and Alkynes

(2011) Marjoke F. Debets et al.   ACCOUNTS OF CHEMICAL RESEARCH

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Decade of Bioorthogonal Chemistry

(2011) Carolyn R. Bertozzi   ACCOUNTS OF CHEMICAL RESEARCH

Biomedical Applications of Tetrazine Cycloadditions

(2011) Neal K. Devaraj et al.   ACCOUNTS OF CHEMICAL RESEARCH

Photoinducible Bioorthogonal Chemistry: A Spatiotemporally Controllable Tool to Visualize and Perturb Proteins in Live Cells

(2011) Reyna K. V. Lim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Prodrugs for improving tumor targetability and efficiency

(2011) Rubi Mahato et al.   ADVANCED DRUG DELIVERY REVIEWS

Copper-Free Sonogashira Cross-Coupling for Functionalization of Alkyne-Encoded Proteins in Aqueous Medium and in Bacterial Cells

(2011) Nan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells

(2011) Arnaud Gautier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase

(2011) Jiaoyang Jiang et al.   Nature Chemical Biology

Palladium-mediated intracellular chemistry

(2011) Rahimi M. Yusop et al.   Nature Chemistry

A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system

(2011) Yiyun Chen et al.   Nature Chemistry

Prodrugs--from Serendipity to Rational Design

(2011) K. M. Huttunen et al.   PHARMACOLOGICAL REVIEWS

Biochemistry and cell signaling taught by bacterial effectors

(2011) Jixin Cui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Fluorescent detection of palladium species with an O-propargylated fluorescein

(2010) Mithun Santra et al.   CHEMICAL COMMUNICATIONS

Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans

(2010) David Soriano del Amo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Turning enzymes ON with small molecules

(2010) Julie A Zorn et al.   Nature Chemical Biology

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amino Acid-Protecting Groups

(2009) Albert Isidro-Llobet et al.   CHEMICAL REVIEWS

Adenylate-forming enzymes

(2009) Stefan Schmelz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Convenient Catalyst for Aqueous and Protein Suzuki−Miyaura Cross-Coupling

(2009) Justin M. Chalker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

(2009) L. Macomber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studies of a fluorogenic probe for palladium and platinum leading to a palladium-specific detection method

(2008) Amanda L. Garner et al.   CHEMICAL COMMUNICATIONS

Allyl Sulfides Are Privileged Substrates in Aqueous Cross-Metathesis: Application to Site-Selective Protein Modification

(2008) Yuya A. Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE