Contemporary approaches to site-selective protein modification

Constructing New Bioorthogonal Reagents and Reactions

(2018) R. David Row et al.   ACCOUNTS OF CHEMICAL RESEARCH

Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins

(2018) Weimin Xuan et al.   ACS Chemical Biology

Highly Reactive and Tracelessly Cleavable Cysteine-Specific Modification of Proteins via 4-Substituted Cyclopentenone

(2018) Jian Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational Tuning of Fluorobenzene Probes for Cysteine-Selective Protein Modification

(2018) Ahmed M. Embaby et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective Cysteine-Cyclooctyne Conjugation

(2018) Chi Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Dual Labeling of Proteins on Cysteine Residues with Chlorotetrazines

(2018) Coline Canovas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Three-Component Organometallic Tyrosine Bioconjugation

(2018) Jun Ohata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thiol-Reactive Bifunctional Chelators for the Creation of Site-Selectively Modified Radioimmunoconjugates with Improved Stability

(2018) Pierre Adumeau et al.   BIOCONJUGATE CHEMISTRY

“Tag and Modify” Protein Conjugation with Dynamic Covalent Chemistry

(2018) Maksymilia Zegota et al.   BIOCONJUGATE CHEMISTRY

FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody–Drug Conjugates

(2018) Byoung-Chul Lee et al.   BIOCONJUGATE CHEMISTRY

Tyrosinase-Mediated Bioconjugation. A Versatile Approach to Chimeric Macromolecules

(2018) Elita Montanari et al.   BIOCONJUGATE CHEMISTRY

Site-specific incorporation of quadricyclane into a protein and photocleavage of the quadricyclane ligation adduct

(2018) Frederick M. Tomlin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Site-selective installation of an electrophilic handle on proteins for bioconjugation

(2018) Bernadette Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthetic post-translational modification of histones

(2018) Simon Nadal et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Palladium Oxidative Addition Complexes for Peptide and Protein Cross-linking

(2018) Koji Kubota et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective Peptide Modification via Photocatalytic Tryptophan β-Position Conjugation

(2018) Younong Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemically Defined Antibody– and Small Molecule–Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis

(2018) Samuele Cazzamalli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemo- and Regioselective Lysine Modification on Native Proteins

(2018) Maria J. Matos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organometallic Gold(III) Reagents for Cysteine Arylation

(2018) Marco S. Messina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Radical Trifluoromethylation of Native Residues in Proteins

(2018) Mateusz Imiołek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast, irreversible modification of cysteines through strain releasing conjugate additions of cyclopropenyl ketones

(2018) Natalee J. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments

(2018) Michelle K. Greene et al.   Chemical Science

Antibody drug conjugates (ADCs) charged with HDAC inhibitor for targeted epigenetic modulation

(2018) Elena Cini et al.   Chemical Science

Scalable thioarylation of unprotected peptides and biomolecules under Ni/photoredox catalysis

(2018) Brandon A. Vara et al.   Chemical Science

Site-selective C–C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

(2018) Richard J. Spears et al.   Chemical Science

Transglutaminase mediated PEGylation of nanobodies for targeted nano-drug delivery

(2018) Tiantian Wu et al.   Journal of Materials Chemistry B

Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins

(2018) Seah Ling Kuan et al.   Advanced Science

Antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class

(2018) Hans-Georg Lerchen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoenzymatic Methods for the Synthesis of Glycoproteins

(2018) Chao Li et al.   CHEMICAL REVIEWS

Recent progress in enzymatic protein labelling techniques and their applications

(2018) Yi Zhang et al.   CHEMICAL SOCIETY REVIEWS

Anti-EGFR Affibodies with Site-Specific Photo-Cross-Linker Incorporation Show Both Directed Target-Specific Photoconjugation and Increased Retention in Tumors

(2018) Michael Brasino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Post-translational site-selective protein backbone α-deuteration

(2018) Sébastien R. G. Galan et al.   Nature Chemical Biology

Antibody–nucleotide conjugate as a substrate for DNA polymerases

(2018) J. Balintová et al.   Chemical Science

Arylation Chemistry for Bioconjugation

(2018) Bradley Pentelute et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proximity-Induced Site-Specific Antibody Conjugation

(2018) Chenfei Yu et al.   BIOCONJUGATE CHEMISTRY

Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology

(2018) Srinivasa Rao Adusumalli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A protein functionalization platform based on selective reactions at methionine residues

(2018) Michael T. Taylor et al.   NATURE

A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins

(2018) Daniel T. Cohen et al.   Nature Chemistry

A Chemoselective Rapid Azo-Coupling Reaction (CRACR) for Unclickable Bioconjugation

(2017) Partha Sarathi Addy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking

(2017) Yulin Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Hexa-rhodium Metallopeptide Catalyst for Site-Specific Functionalization of Natural Antibodies

(2017) Jun Ohata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclopropenones for Metabolic Targeting and Sequential Bioorthogonal Labeling

(2017) R. David Row et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones

(2017) Yingqian Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation

(2017) Allyson M. Freedy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cucurbit[6]uril-Promoted Click Chemistry for Protein Modification

(2017) Joel A. Finbloom et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific incorporation of phosphotyrosine using an expanded genetic code

(2017) Christian Hoppmann et al.   Nature Chemical Biology

Targeting the N terminus for site-selective protein modification

(2017) Christian B Rosen et al.   Nature Chemical Biology

Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials

(2017) Steven Bloom et al.   Nature Chemistry

Global profiling of lysine reactivity and ligandability in the human proteome

(2017) Stephan M. Hacker et al.   Nature Chemistry

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

(2017) Maurício Morais et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions

(2017) Anthony J. Rojas et al.   ORGANIC LETTERS

Redox-based reagents for chemoselective methionine bioconjugation

(2017) Shixian Lin et al.   SCIENCE

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst

(2017) Terence T.-L. Kwan et al.   Chemical Science

Selective N-terminal functionalization of native peptides and proteins

(2017) Diao Chen et al.   Chemical Science

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

(2017) Maximillian T. W. Lee et al.   Chemical Science

Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites

(2017) Jitka Dadová et al.   ACS Central Science

Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins

(2016) Weimin Xuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation

(2016) Zhipeng A. Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Precise Chemical Strategy To Alter the Receptor Specificity of the Adeno-Associated Virus

(2016) Rachel E. Kelemen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Conjugation of Peptides and Proteins via Rebridging of Disulfide Bonds Using the Thiol–Yne Coupling Reaction

(2016) Nils Griebenow et al.   BIOCONJUGATE CHEMISTRY

Systematic Investigation of EDC/sNHS-Mediated Bioconjugation Reactions for Carboxylated Peptide Substrates

(2016) Kyle A. Totaro et al.   BIOCONJUGATE CHEMISTRY

Coordination to Imidazole Ring Switches on Phosphorescence of Platinum Cyclometalated Complexes: The Route to Selective Labeling of Peptides and Proteins via Histidine Residues

(2016) Anastasia I. Solomatina et al.   BIOCONJUGATE CHEMISTRY

Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation

(2016) James T. Patterson et al.   BIOCONJUGATE CHEMISTRY

Phospha-Michael Addition as a New Click Reaction for Protein Functionalization

(2016) Yan-Jiun Lee et al.   CHEMBIOCHEM

Chemical Protein Modification through Cysteine

(2016) Smita B. Gunnoo et al.   CHEMBIOCHEM

Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome

(2016) Seah Ling Kuan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Sequence-Specific 2-Cyanobenzothiazole Ligation

(2016) Carlo P. Ramil et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins

(2016) Yohei Seki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Using Protein-Confined Proximity To Determine Chemical Reactivity

(2016) Tomonori Kobayashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Metal-Site-Guided Arylation of Proteins

(2016) Jens Willwacher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Enzyme Cascade for Selective Modification of Tyrosine Residues in Structurally Diverse Peptides and Proteins

(2016) Anna-Winona Struck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes

(2016) Yoshihiko Iwane et al.   Nature Chemistry

Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

A chemical biology route to site-specific authentic protein modifications

(2016) A. Yang et al.   SCIENCE

Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

(2016) T. H. Wright et al.   SCIENCE

Fast and selective labeling of N-terminal cysteines at neutral pH via thiazolidino boronate formation

(2016) Anupam Bandyopadhyay et al.   Chemical Science

Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides

(2016) Tao Wang et al.   Chemical Science

Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening

(2016) Maruthi Kumar Narayanam et al.   Chemical Science

Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry

(2016) Padma Akkapeddi et al.   Chemical Science

Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation

(2016) Hélio Faustino et al.   Chemical Science

Site-Specific Tandem Knoevenagel Condensation–Michael Addition To Generate Antibody–Drug Conjugates

(2016) Romas A. Kudirka et al.   ACS Medicinal Chemistry Letters

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

(2016) Barbara Bernardim et al.   Nature Communications

Combining Sense and Nonsense Codon Reassignment for Site-Selective Protein Modification with Unnatural Amino Acids

(2016) Zhenling Cui et al.   ACS Synthetic Biology

Tyrosine-Specific Chemical Modification with in Situ Hemin-Activated Luminol Derivatives

(2015) Shinichi Sato et al.   ACS Chemical Biology

Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones

(2015) Han Xiao et al.   ACS Chemical Biology

Incorporation of Unnatural Amino Acids in Response to the AGG Codon

(2015) Byeong Sung Lee et al.   ACS Chemical Biology

Rhodium(II) Metallopeptide Catalyst Design Enables Fine Control in Selective Functionalization of Natural SH3 Domains

(2015) Farrukh Vohidov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase

(2015) Dominik Schumacher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and Optimization of Glaser-Hay Bioconjugations

(2015) Jessica S. Lampkowski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Locked by Design: A Conformationally Constrained Transglutaminase Tag Enables Efficient Site-Specific Conjugation

(2015) Vanessa Siegmund et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific N-Terminal Labeling of Peptides and Proteins using Butelase 1 and Thiodepsipeptide

(2015) Giang K. T. Nguyen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exocyclic Olefinic Maleimides: Synthesis and Application for Stable and Thiol-Selective Bioconjugation

(2015) Dimpy Kalia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Coupling of Click Anchors to Proteins via Trypsiligase

(2015) Christoph Meyer et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues

(2015) Xiuling Li et al.   BIOCONJUGATE CHEMISTRY

Simultaneous Site-Specific Dual Protein Labeling Using Protein Prenyltransferases

(2015) Yi Zhang et al.   BIOCONJUGATE CHEMISTRY

Proximity-Induced Covalent Labeling of Proteins with a Reactive Fluorophore-Binding Peptide Tag

(2015) Murat Sunbul et al.   BIOCONJUGATE CHEMISTRY

Site Selective Azo Coupling for Peptide Cyclization and Affinity Labeling of an SH3 Protein

(2015) Feng Huang et al.   BIOCONJUGATE CHEMISTRY

Efficient Preparation of Site-Specific Antibody–Drug Conjugates Using Phosphopantetheinyl Transferases

(2015) Jan Grünewald et al.   BIOCONJUGATE CHEMISTRY

CBTF: New Amine-to-Thiol Coupling Reagent for Preparation of Antibody Conjugates with Increased Plasma Stability

(2015) Sergii Kolodych et al.   BIOCONJUGATE CHEMISTRY

Strain-Promoted Oxidation-Controlled Cyclooctyne–1,2-Quinone Cycloaddition (SPOCQ) for Fast and Activatable Protein Conjugation

(2015) Annika Borrmann et al.   BIOCONJUGATE CHEMISTRY

Incorporation of a Doubly Functionalized Synthetic Amino Acid into Proteins for Creating Chemical and Light-Induced Conjugates

(2015) Atsushi Yamaguchi et al.   BIOCONJUGATE CHEMISTRY

Multisite Clickable Modification of Proteins Using Lipoic Acid Ligase

(2015) Joseph G. Plaks et al.   BIOCONJUGATE CHEMISTRY

Sortase A-Mediated N-Terminal Modification of Cowpea Chlorotic Mottle Virus for Highly Efficient Cargo Loading

(2015) Lise Schoonen et al.   BIOCONJUGATE CHEMISTRY

Towards the computational design of protein post-translational regulation

(2015) Marta Strumillo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

(2015) Oleksandr Koniev et al.   CHEMICAL SOCIETY REVIEWS

Generating Site-Specifically Modified Proteins via a Versatile and Stable Nucleophilic Carbon Ligation

(2015) Romas Kudirka et al.   CHEMISTRY & BIOLOGY

Chemo- and Regioselective Ethynylation of Tryptophan-Containing Peptides and Proteins

(2015) Morten Borre Hansen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Origin of Orthogonality of Strain-Promoted Click Reactions

(2015) Johannes A. Wagner et al.   CHEMISTRY-A EUROPEAN JOURNAL

Multiply labeling proteins for studies of folding and stability

(2015) Conor M Haney et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Molecular recognition in protein modification with rhodium metallopeptides

(2015) Zachary T Ball   CURRENT OPINION IN CHEMICAL BIOLOGY

Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides

(2015) R. James Christie et al.   JOURNAL OF CONTROLLED RELEASE

C-Terminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action

(2015) Alexandre Murza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization and Expansion of a Site-Selective N-Methylpyridinium-4-carboxaldehyde-Mediated Transamination for Bacterially Expressed Proteins

(2015) Kanwal S. Palla et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Immunosuppressive Antibody–Drug Conjugate

(2015) Rongsheng E. Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Bioorthogonal Ligation of Cyclopropenones Mediated by Triarylphosphines

(2015) Hui-Wen Shih et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

1,2,4-Triazines Are Versatile Bioorthogonal Reagents

(2015) David N. Kamber et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organometallic palladium reagents for cysteine bioconjugation

(2015) Ekaterina V. Vinogradova et al.   NATURE

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

(2015) Sophie M. Lehar et al.   NATURE

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

(2015) James I MacDonald et al.   Nature Chemical Biology

Photo-lysine captures proteins that bind lysine post-translational modifications

(2015) Tangpo Yang et al.   Nature Chemical Biology

Recent advances in the molecular design of synthetic vaccines

(2015) Lyn H. Jones   Nature Chemistry

Site-selective protein-modification chemistry for basic biology and drug development

(2015) Nikolaus Krall et al.   Nature Chemistry

π-Clamp-mediated cysteine conjugation

(2015) Chi Zhang et al.   Nature Chemistry

Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

(2015) Estela Haldón et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Site-Specific Chemical Modification of Peptide and Protein by Thiazolidinediones

(2015) Peng Wang et al.   ORGANIC LETTERS

Diazo compounds for the bioreversible esterification of proteins

(2015) Nicholas A. McGrath et al.   Chemical Science

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

N-Terminal Protein Modification by Substrate-Activated Reverse Proteolysis

(2014) Sandra Liebscher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Allenamides as Orthogonal Handles for Selective Modification of Cysteine in Peptides and Proteins

(2014) Ata Abbas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cysteine-Selective Reactions for Antibody Conjugation

(2014) Pedro M. S. D. Cal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetically Encoding Photoswitchable Click Amino Acids inEscherichia coliand Mammalian Cells

(2014) Christian Hoppmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bridging Disulfides for Stable and Defined Antibody Drug Conjugates

(2014) George Badescu et al.   BIOCONJUGATE CHEMISTRY

Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy

(2014) L. Nathan Tumey et al.   BIOCONJUGATE CHEMISTRY

Selective Irreversible Chemical Tagging of Cysteine with 3-Arylpropiolonitriles

(2014) Oleksandr Koniev et al.   BIOCONJUGATE CHEMISTRY

Developments in the Field of Bioorthogonal Bond Forming Reactions—Past and Present Trends

(2014) Mathias King et al.   BIOCONJUGATE CHEMISTRY

Long-Term Stabilization of Maleimide–Thiol Conjugates

(2014) Shaun D. Fontaine et al.   BIOCONJUGATE CHEMISTRY

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

(2014) Kathrin Lang et al.   CHEMICAL REVIEWS

Transition metal-mediated bioorthogonal protein chemistry in living cells

(2014) Maiyun Yang et al.   CHEMICAL SOCIETY REVIEWS

N-Terminal Modification of Proteins with o-Aminophenols

(2014) Allie C. Obermeyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore

(2014) Zhiwei Zuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

(2014) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET

(2014) Kaihang Wang et al.   Nature Chemistry

Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation

(2014) Ampofo Darko et al.   Chemical Science

Strain-promoted sydnone bicyclo-[6.1.0]-nonyne cycloaddition

(2014) Stephen Wallace et al.   Chemical Science

Selective and reversible photochemical derivatization of cysteine residues in peptides and proteins

(2014) Selvanathan Arumugam et al.   Chemical Science

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Primary arylamine-based tyrosine-targeted protein modification

(2014) Lin Wang et al.   RSC Advances

Unnatural amino acid incorporation in E. coli: current and future applications in the design of therapeutic proteins

(2014) Kim Wals et al.   Frontiers in Chemistry

Genetic code expansion as a tool to study regulatory processes of transcription

(2014) Moritz J. Schmidt et al.   Frontiers in Chemistry

Protein Organic Chemistry and Applications for Labeling and Engineering in Live-Cell Systems

(2013) Yousuke Takaoka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic Labeling of Proteins: Techniques and Approaches

(2013) Mohammad Rashidian et al.   BIOCONJUGATE CHEMISTRY

A Need for Speed: Genetic Encoding of Rapid Cycloaddition Chemistries for Protein Labelling in Living Cells

(2012) Moritz J. Schmidt et al.   CHEMBIOCHEM

Site-Specific Traceless Coupling of Potent Cytotoxic Drugs to Recombinant Antibodies for Pharmacodelivery

(2012) Giulio Casi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A “Tag-and-Modify” Approach to Site-Selective Protein Modification

(2011) Justin M. Chalker et al.   ACCOUNTS OF CHEMICAL RESEARCH

Theranostics: Combining Imaging and Therapy

(2011) Sneha S. Kelkar et al.   BIOCONJUGATE CHEMISTRY

Bringing chemistry to life

(2011) Michael Boyce et al.   NATURE METHODS

Tyrosine Bioconjugation through Aqueous Ene-Type Reactions: A Click-Like Reaction for Tyrosine

(2010) Hitoshi Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonnatural Amino Acids for Site-Specific Protein Conjugation

(2009) Albert J. de Graaf et al.   BIOCONJUGATE CHEMISTRY

Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity

(2009) John M. Antos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facile Conversion of Cysteine and Alkyl Cysteines to Dehydroalanine on Protein Surfaces: Versatile and Switchable Access to Functionalized Proteins

(2008) Gonçalo J. L. Bernardes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY