Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans

Oxidative DNA Damage Is Prevented by Extracts of Olive Oil, Hydroxytyrosol, and Other Olive Phenolic Compounds in Human Blood Mononuclear Cells and HL60 Cells

(2018) Roberto Fabiani et al.   JOURNAL OF NUTRITION

The Substrate Specificity of Sirtuins

(2016) Poonam Bheda et al.   Annual Review of Biochemistry

AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives

(2016) Claudia Marinangeli et al.   CURRENT DRUG TARGETS

AMPK Function in Aging Process

(2016) Rocío Ruiz et al.   CURRENT DRUG TARGETS

Natural Polyphenols and their Synthetic Analogs as Emerging Anticancer Agents

(2016) Ramon Colomer et al.   CURRENT DRUG TARGETS

Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study

(2016) Xiaohui Guo et al.   Oxidative Medicine and Cellular Longevity

Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

(2016) Biplab Dasgupta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Olive oil consumption and risk of type 2 diabetes in US women

(2015) Marta Guasch-Ferré et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

Oleuropein aglycone in lipid bilayer membranes. A molecular dynamics study

(2015) Vicente Galiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Virgin olive oil: a key food for cardiovascular risk protection

(2015) María-Isabel Covas et al.   BRITISH JOURNAL OF NUTRITION

Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial

(2015) Stacey Lockyer et al.   BRITISH JOURNAL OF NUTRITION

Dietary polyphenols and chromatin remodeling

(2015) Gian Luigi Russo et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Oleuropein-Enriched Olive Leaf Extract Affects Calcium Dynamics and Impairs Viability of Malignant Mesothelioma Cells

(2015) Carla Marchetti et al.   Evidence-based Complementary and Alternative Medicine

Prediabetes and alzheimer's disease

(2015) Deepthi Rapaka et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

(2015) Yuliya Mikhed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oleuropein-Rich Diet Attenuates Hyperglycemia and Impaired Glucose Tolerance in Type 2 Diabetes Model Mouse

(2015) Kazutoshi Murotomi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Identification of compounds from high-fat and extra virgin olive oil-supplemented diets in whole mouse liver extracts and isolated mitochondria using mass spectrometry

(2015) Gustavo Aparecido dos Santos et al.   JOURNAL OF MASS SPECTROMETRY

Olive Oil Polyphenols Decrease LDL Concentrations and LDL Atherogenicity in Men in a Randomized Controlled Trial

(2015) Álvaro Hernáez et al.   JOURNAL OF NUTRITION

Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms

(2015) Andrea Di Francesco et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

AMPK and autophagy in glucose/glycogen metabolism

(2015) Joohun Ha et al.   MOLECULAR ASPECTS OF MEDICINE

Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line

(2015) CHUN-MEI YAN et al.   Molecular Medicine Reports

Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

(2015) Chloe Goldsmith et al.   MOLECULES

Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates

(2015) Ilaria Luccarini et al.   NEUROBIOLOGY OF AGING

Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial

(2015) A. Medina-Remón et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin-induced diabetes mellitus in experimental animals

(2015) SibghatullahMuhammad Ali Sangi et al.   Pharmacognosy Magazine

Effects of the Olive Tree Leaf Constituents on Myocardial Oxidative Damage and Atherosclerosis

(2015) Panagiotis Efentakis et al.   PLANTA MEDICA

Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms

(2015) I. Rodriguez-Ramiro et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Benefits of the Mediterranean Diet: Insights From the PREDIMED Study

(2015) Miguel A. Martínez-González et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

(2015) Stefania Rigacci et al.   Oncotarget

Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects

(2015) F Violi et al.   Nutrition & Diabetes

Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial

(2015) Estefanía Toledo et al.   JAMA Internal Medicine

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

The Role of Dietary Extra Virgin Olive Oil and Corn Oil on the Alteration of Epigenetic Patterns in the Rat DMBA-Induced Breast Cancer Model

(2015) Cristina Rodríguez-Miguel et al.   PLoS One

Components of a standardised olive leaf dry extract (Ph. Eur.) promote hypothiocyanite production by lactoperoxidase

(2014) Jörg Flemmig et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Olive Oil Polyphenols Enhance High-Density Lipoprotein Function in Humans

(2014) Álvaro Hernáez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells

(2014) Zeinab Korany Hassan et al.   Asian Pacific Journal of Cancer Prevention

Circulating cytokines in relation to the extent and composition of coronary atherosclerosis: Results from the ATHEROREMO-IVUS study

(2014) Linda C. Battes et al.   ATHEROSCLEROSIS

Beneficial properties of natural phenols: Highlight on protection against pathological conditions associated with amyloid aggregation

(2014) Massimo Stefani et al.   BIOFACTORS

Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study

(2014) Marta Guasch-Ferré et al.   BMC Medicine

Age-Related Increase in Levels of 5-Hydroxymethylcytosine in Mouse Hippocampus is Prevented by Caloric Restriction

(2014) Leonidas Chouliaras et al.   Current Alzheimer Research

Islet Amyloid Polypeptide (IAPP): A Second Amyloid in Alzheimer's Disease

(2014) Janelle Fawver et al.   Current Alzheimer Research

microRNAs as New Targets of Dietary Polyphenols

(2014) Cinta Blade et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Effect of the Mediterranean diet on heart failure biomarkers: a randomized sample from the PREDIMED trial

(2014) Montserrat Fitó et al.   EUROPEAN JOURNAL OF HEART FAILURE

Rapid down-regulation of hepatic lipid metabolism by phenolic fraction from extra virgin olive oil

(2014) Paola Priore et al.   EUROPEAN JOURNAL OF NUTRITION

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Olive Leaf Extract Attenuates Obesity in High-Fat Diet-Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis

(2014) Ying Shen et al.   Evidence-based Complementary and Alternative Medicine

Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols

(2014) Stefania Rigacci et al.   Expert Review of Neurotherapeutics

Mediterranean Diet and Healthy Ageing: A Sicilian Perspective

(2014) Sonya Vasto et al.   GERONTOLOGY

Epigenetic Targets of Polyphenols in Cancer

(2014) Pinglin Yang et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signaling molecules and cardiomyocyte metabolism

(2014) Ioanna Andreadou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Extra virgin olive oil phenols down-regulate lipid synthesis in primary-cultured rat-hepatocytes

(2014) Paola Priore et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oleuropein Induced Apoptosis in HeLa Cells via a Mitochondrial Apoptotic Cascade Associated With Activation of the c-Jun NH2-Terminal Kinase

(2014) Jie Yao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Resveratrol attenuates inflammation in the rat heart subjected to ischemia-reperfusion: Role of the TLR4/NF-κB signaling pathway

(2014) Jingbo Li et al.   Molecular Medicine Reports

Oleuropein attenuates visceral adiposity in high-fat diet-induced obese mice through the modulation of WNT10b- and galanin-mediated signalings

(2014) Narae Kuem et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Alzheimer's disease and epigenetic diet

(2014) Zeynep Sezgin et al.   NEUROCHEMISTRY INTERNATIONAL

The Natural Olive Constituent Oleuropein Induces Nutritional Cardioprotection in Normal and Cholesterol-Fed Rabbits: Comparison with Preconditioning

(2014) Ioanna Andreadou et al.   PLANTA MEDICA

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans

(2013) María-Jesús Oliveras-López et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Oleuropein Induces Anti-metastatic Effects in Breast Cancer

(2013) Zeinab K. Hassan et al.   Asian Pacific Journal of Cancer Prevention

Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols

(2013) Angelique Camilleri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

AMP-activated protein kinase (AMPK) beyond metabolism

(2013) Toran Sanli et al.   CANCER BIOLOGY & THERAPY

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

(2013) Javier A. Menendez et al.   CELL CYCLE

Epigenetic and Disease Targets by Polyphenols

(2013) Min-Hsiung Pan et al.   CURRENT PHARMACEUTICAL DESIGN

Olive oil has a beneficial effect on impaired glucose regulation and other cardiometabolic risk factors. Di@bet.es study

(2013) F Soriguer et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Bioavailability of phenolics from an oleuropein-rich olive (Olea europaea) leaf extract and its acute effect on plasma antioxidant status: comparison between pre- and postmenopausal women

(2013) R. García-Villalba et al.   EUROPEAN JOURNAL OF NUTRITION

Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma

(2013) Michaela Svobodova et al.   Genes and Nutrition

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

(2013) Massimo Stefani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The specific characteristics of DIC syndrome vary with different clinical settings in the newborn

(2013) Dmitry Ivanov et al.   Journal of Maternal-Fetal & Neonatal Medicine

Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial

(2013) Elena H Martínez-Lapiscina et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Olive oil polyphenols enhance the expression of cholesterol efflux related genes in vivo in humans. A randomized controlled trial

(2013) Marta Farràs et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Novel insights of dietary polyphenols and obesity

(2013) Shu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms

(2013) Vincent B. Owona Ayissi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaeaL.) leaf extract

(2013) Martin de Bock et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells

(2013) Adele Chimento et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nutrition and Healthy Ageing: Calorie Restriction or Polyphenol-Rich “MediterrAsian” Diet?

(2013) Kathrin Pallauf et al.   Oxidative Medicine and Cellular Longevity

Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease

(2013) Lina Adwan et al.   PHARMACOLOGY & THERAPEUTICS

Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway

(2013) Andrzej Parzonko et al.   PHYTOMEDICINE

Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial

(2013) Martin de Bock et al.   PLoS One

Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit

(2013) Luisa Diomede et al.   PLoS One

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Autophagy, polyphenols and healthy ageing

(2012) Kathrin Pallauf et al.   AGEING RESEARCH REVIEWS

Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer

(2012) Egeria Scoditti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Oleuropein, an Anti-oxidant Polyphenol Constituent of Olive Promotes α-Secretase Cleavage of the Amyloid Precursor Protein (AβPP)

(2012) Myrta Kostomoiri et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells

(2012) Maha H. Elamin et al.   FOOD AND CHEMICAL TOXICOLOGY

Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats

(2012) Julio Wainstein et al.   JOURNAL OF MEDICINAL FOOD

Modulation of Tau Protein Fibrillization by Oleocanthal

(2012) Maria Chiara Monti et al.   JOURNAL OF NATURAL PRODUCTS

A metabolite-profiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC–ESI-QTOF-MS

(2012) R. Quirantes-Piné et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans

(2012) Ana Cañuelo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Oleuropein reduces free fatty acid-induced lipogenesis via lowered extracellular signal-regulated kinase activation in hepatocytes

(2012) Wonhee Hur et al.   NUTRITION RESEARCH

Phenolic Secoiridoids in Extra Virgin Olive Oil Impede Fibrogenic and Oncogenic Epithelial-to-Mesenchymal Transition: Extra Virgin Olive Oil As a Source of Novel Antiaging Phytochemicals

(2012) Alejandro Vazquez-Martin et al.   REJUVENATION RESEARCH

A Diet Rich in Olive Oil Phenolics Reduces Oxidative Stress in the Heart of SAMP8 Mice by Induction of Nrf2-Dependent Gene Expression

(2012) Banu Bayram et al.   REJUVENATION RESEARCH

MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan

(2011) Ehab H. Sarsour et al.   AGE

p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis

(2011) P. Khanal et al.   CARCINOGENESIS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Polyphenolic Glycosides and Aglycones Utilize Opposing Pathways To Selectively Remodel and Inactivate Toxic Oligomers of Amyloid β

(2011) Ali Reza A. Ladiwala et al.   CHEMBIOCHEM

Naturally Occurring Iridoids and Secoiridoids. An Updated Review, Part 4

(2011) Biswanath Dinda et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Aβ(1-42) Aggregates into Non-Toxic Amyloid Assemblies in the Presence of the Natural Polyphenol Oleuropein Aglycon

(2011) Stefania Rigacci et al.   Current Alzheimer Research

Olive Oil and Haemostasis: Platelet Function, Thrombogenesis and Fibrinolysis

(2011) Javier Delgado-Lista et al.   CURRENT PHARMACEUTICAL DESIGN

Epigenetic changes induced by curcumin and other natural compounds

(2011) Simone Reuter et al.   Genes and Nutrition

Unusual Pungency from Extra-Virgin Olive Oil Is Attributable to Restricted Spatial Expression of the Receptor of Oleocanthal

(2011) C. Peyrot des Gachons et al.   JOURNAL OF NEUROSCIENCE

First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics

(2011) Baojian Wu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells

(2011) Riadh Drira et al.   LIFE SCIENCES

Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake

(2011) Aida Serra et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The postprandial inflammatory response after ingestion of heated oils in obese persons is reduced by the presence of phenol compounds

(2011) A. Perez-Herrera et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts

(2011) Jaouad Anter et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Oleuropein and derivatives from olives as Tau aggregation inhibitors

(2011) Anthony Daccache et al.   NEUROCHEMISTRY INTERNATIONAL

Olive oil consumption, plasma oleic acid, and stroke incidence: The Three-City Study

(2011) C. Samieri et al.   NEUROLOGY

The chemistry and biotransformation of tea constituents

(2011) Shengmin Sang et al.   PHARMACOLOGICAL RESEARCH

Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice

(2011) Robert Domitrović et al.   PHARMACOLOGICAL RESEARCH

Mediterranean diet pyramid today. Science and cultural updates

(2011) Anna Bach-Faig et al.   PUBLIC HEALTH NUTRITION

Polyphenolic Extracts from Olea europea L. Protect Against Cytokine-Induced β-Cell Damage Through Maintenance of Redox Homeostasis

(2011) Ahmet Cumaoğlu et al.   REJUVENATION RESEARCH

The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems

(2011) Stephen Barnes et al.   Food & Function

Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population

(2010) C. C. Tangney et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis

(2010) Francesco Sofi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

(2010) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The life span-prolonging effect of Sirtuin-1 is mediated by autophagy

(2010) Eugenia Morselli et al.   Autophagy

Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by nuclear magnetic resonance spectroscopy

(2010) Petros A. Galanakis et al.   BIOPOLYMERS

Hepatoprotective effect of oleuropein in mice: Mechanisms uncovered by gene expression profiling

(2010) Yunjung Kim et al.   Biotechnology Journal

Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil

(2010) Antonio Camargo et al.   BMC GENOMICS

Endothelial mitochondria and heart disease

(2010) S. M. Davidson   CARDIOVASCULAR RESEARCH

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial

(2010) Valentini Konstantinidou et al.   FASEB JOURNAL

Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells

(2010) Zouhaier Bouallagui et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells

(2010) Maria Notarnicola et al.   Genes and Nutrition

Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice

(2010) Soyoung Park et al.   JOURNAL OF HEPATOLOGY

Olive Leaf Extract Attenuates Cardiac, Hepatic, and Metabolic Changes in High Carbohydrate–, High Fat–Fed Rats

(2010) Hemant Poudyal et al.   JOURNAL OF NUTRITION

Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes

(2010) Geovana MX Ebaid et al.   Nutrition Journal

The Effect of Minor Constituents of Olive Oil on Cardiovascular Disease: New Findings

(2010) Francesco Visioli et al.   NUTRITION REVIEWS

Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase

(2010) J. Flemmig et al.   PHYTOMEDICINE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Simultaneous quantification of oleuropein and its metabolites in rat plasma by liquid chromatography electrospray ionization tandem mass spectrometry

(2009) Fotini N. Bazoti et al.   BIOMEDICAL CHROMATOGRAPHY

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

NAD+, Sirtuins, and Cardiovascular Disease

(2009) Nica Borradaile et al.   CURRENT PHARMACEUTICAL DESIGN

Olive Oil and Cognition: Results from the Three-City Study

(2009) Claudine Berr et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Variations of iridoid oleuropein in Italian olive varieties during growth and maturation

(2009) Alfonso Ranalli et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Antidiabetic and Antioxidant Effects of Hydroxytyrosol and Oleuropein from Olive Leaves in Alloxan-Diabetic Rats

(2009) Hedya Jemai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

(2009) Wenkai Li et al.   JOURNAL OF NEUROCHEMISTRY

Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes

(2009) Jiejie Hao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin☆

(2009) Stefania Rigacci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Detection of interactions of the β-amyloid peptide with small molecules employing transferred NOEs

(2009) Dimitra Benaki et al.   JOURNAL OF PEPTIDE SCIENCE

Stability of oleuropein in the human proximal gut

(2009) Constantinos Markopoulos et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Valproic Acid is Neuroprotective in the Rotenone Rat Model of Parkinson’s Disease: Involvement of α-Synuclein

(2009) Barbara Monti et al.   NEUROTOXICITY RESEARCH

Time Course of Changes in the Expression of Insulin Sensitivity-Related Genes after an Acute Load of Virgin Olive Oil

(2009) Valentini Konstantinidou et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Olive leaf extract prevents spontaneous occurrence of non-alcoholic steatohepatitis in SHR/NDmcr-cp rats

(2009) Katsuhisa Omagari et al.   PATHOLOGY

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

(2009) Jason Pitt et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis

(2008) Lihui Wang et al.   EUROPEAN JOURNAL OF NUTRITION

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT

Akt/FOXO3a/SIRT1-Mediated Cardioprotection byn-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival and Longevity

(2008) Samson Mathews Samuel et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Localization of the noncovalent binding site between amyloid-β-peptide and oleuropein using electrospray ionization FT-ICR mass spectrometry

(2008) Fotini N. Bazoti et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The use of diversity profiling to characterize chemical modulators of the histone deacetylases

(2008) Leonard Blackwell et al.   LIFE SCIENCES

Biological and Pharmacological Activities of Iridoids: Recent Developments

(2008) Rosa Tundis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY