Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

The role of inflammation in age-related disease

(2016) T. Kevin Howcroft et al.   Aging-US

Post-ischaemic silencing of p66Shcreduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

(2015) R.D. Spescha et al.   EUROPEAN HEART JOURNAL

Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells

(2015) Maria T. Mochin et al.   MICROVASCULAR RESEARCH

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Histone methylation and aging: Lessons learned from model systems

(2014) Brenna S. McCauley et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mito-nuclear interactions as drivers of gene movement on and off the X-chromosome

(2014) Björn Rogell et al.   BMC GENOMICS

Genetics and epigenetics of aging and longevity

(2014) Alexey Moskalev et al.   CELL CYCLE

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

(2014) Susanne Karbach et al.   CURRENT PHARMACEUTICAL DESIGN

mtDNA mutations in human aging and longevity: Controversies and new perspectives opened by high-throughput technologies

(2014) Federica Sevini et al.   EXPERIMENTAL GERONTOLOGY

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

(2014) Rachel A. Gioscia-Ryan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Formation and repair of oxidative damage in the mitochondrial DNA

(2014) Meltem Muftuoglu et al.   MITOCHONDRION

Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease

(2014) Chandrika Canugovi et al.   NEUROBIOLOGY OF AGING

Human AP Endonuclease 1: A Potential Marker for the Prediction of Environmental Carcinogenesis Risk

(2014) Jae Sung Park et al.   Oxidative Medicine and Cellular Longevity

Nitrate tolerance as a model of vascular dysfunction: Roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress

(2014) Andreas Daiber et al.   Pharmacological Reports

Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

(2014) Leslie S. Itsara et al.   PLoS Genetics

Oxidative Stress, Hypoxia, and Autophagy in the Neovascular Processes of Age-Related Macular Degeneration

(2014) Janusz Blasiak et al.   Biomed Research International

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress

(2013) Rafal R. Nazarewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial ROS in the prohypertensive immune response

(2013) Rafal R. Nazarewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

(2013) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models

(2013) Swenja Kröller-Schön et al.   ANTIOXIDANTS & REDOX SIGNALING

CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction

(2013) Michael Hausding et al.   BASIC RESEARCH IN CARDIOLOGY

Aging affects high-density lipoprotein composition and function

(2013) Michael Holzer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Deletion of the Activated Protein-1 Transcription Factor JunD Induces Oxidative Stress and Accelerates Age-Related Endothelial Dysfunction

(2013) Francesco Paneni et al.   CIRCULATION

Methionine sulfoxide reductase A rs10903323 G/A polymorphism is associated with increased risk of coronary artery disease in a Chinese population

(2013) Haiyong Gu et al.   CLINICAL BIOCHEMISTRY

Oxidative stress and vascular inflammation in aging

(2013) Mariam El Assar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione Peroxidase-1 Deficiency Potentiates Dysregulatory Modifications of Endothelial Nitric Oxide Synthase and Vascular Dysfunction in Aging

(2013) Matthias Oelze et al.   HYPERTENSION

Association Between Advanced Age and Vascular Disease in Different Arterial Territories

(2013) Nazir Savji et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mechanism of Homologous Recombination and Implications for Aging-Related Deletions in Mitochondrial DNA

(2013) X. J. Chen   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

The p66Shc gene paves the way for healthspan: Evolutionary and mechanistic perspectives

(2013) Alessandra Berry et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

(2013) Scott R. Kennedy et al.   PLoS Genetics

Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model

(2012) Pierre-Antoine Crassous et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

(2012) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress and pulmonary fibrosis

(2012) Paul Cheresh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Free radical biology of the cardiovascular system

(2012) Alex F. Chen et al.   CLINICAL SCIENCE

Global heterochromatin loss

(2012) Amy Tsurumi et al.   Epigenetics

Acute Reversal of Endothelial Dysfunction in the Elderly After Antioxidant Consumption

(2012) D. Walter Wray et al.   HYPERTENSION

Flow-mediated dilation and cardiovascular risk prediction: A systematic review with meta-analysis

(2012) Rouyanne T. Ras et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling

(2012) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear and Mitochondrial DNA Repair in Selected Eukaryotic Aging Model Systems

(2012) Ricardo Gredilla et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress and endothelial dysfunction: Therapeutic implications

(2011) Tommaso Gori et al.   ANNALS OF MEDICINE

Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2011) Philip Wenzel et al.   CIRCULATION

Aging and vascular endothelial function in humans

(2011) Douglas R. Seals et al.   CLINICAL SCIENCE

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans

(2011) Anthony J. Donato et al.   JOURNAL OF PHYSIOLOGY-LONDON

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease

(2011) Kim J. Krishnan et al.   NEUROBIOLOGY OF AGING

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Redox Control Systems in the Nucleus: Mechanisms and Functions

(2010) Young-Mi Go et al.   ANTIOXIDANTS & REDOX SIGNALING

p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria

(2010) Paolo Pinton et al.   CELL CYCLE

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

High-Density Lipoprotein-Mediated Anti-Atherosclerotic and Endothelial-Protective Effects: A Potential Novel Therapeutic Target in Cardiovascular Disease

(2010) Christian Besler et al.   CURRENT PHARMACEUTICAL DESIGN

DNA repair in mammalian mitochondria: Much more than we thought?

(2010) Pingfang Liu et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Is oxidative stress a therapeutic target in cardiovascular disease?

(2010) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression

(2010) Edith Lubos et al.   FASEB JOURNAL

Mitochondrial oxidative stress and mammalian healthspan

(2010) Jonathan Wanagat et al.   MECHANISMS OF AGEING AND DEVELOPMENT

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Endothelial dysfunction and aging: An update

(2009) María Dolores Herrera et al.   AGEING RESEARCH REVIEWS

Differential Expression of the Antioxidant Repair Enzyme Methionine Sulfoxide Reductase (MSRA and MSRB) in Human Skin

(2009) Wirach M Taungjaruwinai et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase

(2009) Anthony J. Donato et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Thioredoxin-1 and Endothelial Cell Aging: Role in Cardiovascular Diseases

(2009) Joachim Altschmied et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66Shc and monoamine oxidase

(2009) Fabio Di Lisa et al.   BASIC RESEARCH IN CARDIOLOGY

Is the oxidative stress theory of aging dead?

(2009) Viviana I. Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

(2009) Nadja C. de Souza-Pinto et al.   DNA REPAIR

The mitochondrial theory of aging: Insight from transgenic and knockout mouse models

(2009) Youngmok C. Jang et al.   EXPERIMENTAL GERONTOLOGY

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

(2009) P. Hemachandra Reddy   EXPERIMENTAL NEUROLOGY

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

(2009) Adam B. Salmon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

(2009) Jaakko L. O. Pohjoismäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

(2009) Annemarieke E. Loot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF-α modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis

(2009) Jyotirmoy Nandi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction

(2008) Thomas Münzel et al.   ANNALS OF MEDICINE

Nitric Oxide, Tetrahydrobiopterin, Oxidative Stress, and Endothelial Dysfunction in Hypertension

(2008) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

First Evidence for a Crosstalk Between Mitochondrial and NADPH Oxidase-Derived Reactive Oxygen Species in Nitroglycerin-Triggered Vascular Dysfunction

(2008) Philip Wenzel et al.   ANTIOXIDANTS & REDOX SIGNALING

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

(2008) Philip Wenzel et al.   CARDIOVASCULAR RESEARCH

Nitroglycerin-Induced S-nitrosylation and Desensitization of Soluble Guanylyl Cyclase Contribute to Nitrate Tolerance

(2008) Nazish Sayed et al.   CIRCULATION RESEARCH

Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators

(2008) J. V. Busik et al.   DIABETES

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protection of vascular smooth muscle cells by over-expressed methionine sulphoxide reductase A: Role of intracellular localization and substrate availability

(2008) Ronny Haenold et al.   FREE RADICAL RESEARCH

Glutathione Peroxidase-1 Plays a Major Role in Protecting Against Angiotensin II–Induced Vascular Dysfunction

(2008) Sophocles Chrissobolis et al.   HYPERTENSION

The role of p66Shc deletion in age-associated arterial dysfunction and disease states

(2008) Giovanni G. Camici et al.   JOURNAL OF APPLIED PHYSIOLOGY

Age-related macular degeneration

(2008) Hanna R Coleman et al.   LANCET

Age-Related Alterations in Reactivity of Cerebral Arterioles: Role of Oxidative Stress

(2008) William G. Mayhan et al.   MICROCIRCULATION

Inactivation of Soluble Guanylate Cyclase by Stoichiometric S-Nitrosation

(2008) B. Mayer et al.   MOLECULAR PHARMACOLOGY

Activation of the lifespan regulator p66Shc through reversible disulfide bond formation

(2008) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive antioxidant methionine accumulation in respiratory chain complexes explains the use of a deviant genetic code in mitochondria

(2008) A. Bender et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrially encoded cysteine predicts animal lifespan

(2007) Bernd Moosmann et al.   AGING CELL

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH