Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms

Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   DIGESTIVE AND LIVER DISEASE

Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease

(2015) Sanja Stojsavljević   WORLD JOURNAL OF GASTROENTEROLOGY

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

(2014) Ana Rodriguez-Mateos et al.   ARCHIVES OF TOXICOLOGY

Cyanidin-3-O-β-glucoside protects primary mouse hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction and the PI3K/Akt pathway

(2014) Xinwei Jiang et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

(2014) Veronique S. Chachay et al.   Clinical Gastroenterology and Hepatology

Crosstalk between intestinal microbiota, adipose tissue and skeletal muscle as an early event in systemic low-grade inflammation and the development of obesity and diabetes

(2014) Christian Bleau et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Effects of bayberry juice on inflammatory and apoptotic markers in young adults with features of non-alcoholic fatty liver disease

(2014) Honghui Guo et al.   NUTRITION

Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease

(2014) Forouzan Faghihzadeh et al.   NUTRITION RESEARCH

Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2014) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans

(2014) Hong-Chou Chang et al.   Food & Function

Fatty Acid–Regulated Transcription Factors in the Liver

(2013) Donald B. Jump et al.   Annual Review of Nutrition

Quercetin Decreases Liver Damage in Mice with Non-Alcoholic Steatohepatitis

(2013) Éder Marcolin et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis

(2013) Anisha A. Gupte et al.   Current Diabetes Reports

Resveratrol modulates autophagy and NF-κB activity in a murine model for treating non-alcoholic fatty liver disease

(2013) Lake Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Free radical biology for medicine: learning from nonalcoholic fatty liver disease

(2013) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

3-Caffeoyl, 4-dihydrocaffeoylquinic acid fromSalicornia herbaceaattenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway

(2013) Yong Pil Hwang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Modulation of metabolic syndrome-related inflammation by cocoa

(2013) Yeyi Gu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation

(2013) João Marcus Oliveira Andrade et al.   NUTRITION

Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells

(2013) Satyakumar Vidyashankar et al.   TOXICOLOGY IN VITRO

Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines

(2013) Elaine Hui et al.   Journal of Diabetes Investigation

PPAR-α as a Key Nutritional and Environmental Sensor for Metabolic Adaptation

(2013) Alejandra V. Contreras et al.   Advances in Nutrition

Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation

(2013) Yizhe Cui et al.   Redox Biology

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

(2012) Jorge Joven et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Polyphenol Extract ofHibiscus sabdariffaL. Ameliorates Acetaminophen-Induced Hepatic Steatosis by Attenuating the Mitochondrial Dysfunctionin Vivoandin Vitro

(2012) Chao-Hsin LEE et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?

(2012) Lokpal S. Bhatia et al.   EUROPEAN HEART JOURNAL

Quercetin Treatment Ameliorates Inflammation and Fibrosis in Mice with Nonalcoholic Steatohepatitis1–3

(2012) Eder Marcolin et al.   JOURNAL OF NUTRITION

Modulation of lipid metabolism by polyphenol-rich grape skin extract improves liver steatosis and adiposity in high fat fed mice

(2012) Hae-Jin Park et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet

(2012) Goiuri Alberdi et al.   NUTRITION

Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet

(2012) Morten Møller Poulsen et al.   NUTRITION RESEARCH

Moroorange juice prevents fatty liver in mice

(2012) Federico Salamone   WORLD JOURNAL OF GASTROENTEROLOGY

Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2012) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Neonatal exposure to genistein ameliorates high-fat diet-induced non-alcoholic steatohepatitis in rats

(2011) Chengfei Huang et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress

(2011) S. Gómez-Zorita et al.   BRITISH JOURNAL OF NUTRITION

Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress

(2011) Ildefonso Rodríguez-Ramiro et al.   EUROPEAN JOURNAL OF NUTRITION

Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models

(2011) Tsutomu Shimada et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms

(2011) Guiyuan Ji et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibitory Effect of Blueberry Polyphenolic Compounds on Oleic Acid-Induced Hepatic Steatosis in Vitro

(2011) Yixiang Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Rutin Inhibits Oleic Acid Induced Lipid Accumulation via Reducing Lipogenesis and Oxidative Stress in Hepatocarcinoma Cells

(2011) Cheng-Hsun Wu et al.   JOURNAL OF FOOD SCIENCE

Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ

(2011) Honghui Guo et al.   JOURNAL OF LIPID RESEARCH

Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice

(2011) Yumi Tsuruta et al.   Lipids in Health and Disease

Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice

(2011) R. Beltrán-Debón et al.   PHYTOMEDICINE

A polyphenol extract modifies quantity but not quality of liver fatty acid content in high-fat–high-sucrose diet-fed rats: possible implication of the sirtuin pathway

(2010) Manar Aoun et al.   BRITISH JOURNAL OF NUTRITION

The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease

(2010) Mi-Hyun Kim et al.   BRITISH JOURNAL OF NUTRITION

AMP-activated protein kinase and its downstream transcriptional pathways

(2010) Carles Cantó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells

(2010) Ildefonso Rodríguez-Ramiro et al.   EUROPEAN JOURNAL OF NUTRITION

Coffee reduces liver damage in a rat model of steatohepatitis: The underlying mechanisms and the role of polyphenols and melanoidins

(2010) Paola Vitaglione et al.   HEPATOLOGY

Resveratrol commonly displays hormesis: Occurrence and biomedical significance

(2010) Edward J Calabrese et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress

(2010) Jin-Feng Liu et al.   PHYTOTHERAPY RESEARCH

Fatty liver: Role of inflammation and fatty acid nutrition

(2010) Christopher D Byrne   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

(2009) B. Viollet et al.   Acta Physiologica

Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion

(2009) Paulina Pettinelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase

(2008) Jing SHANG et al.   ACTA PHARMACOLOGICA SINICA

Resveratrol inhibits nonalcoholic fatty liver disease in rats

(2008) Luis Bujanda et al.   BMC GASTROENTEROLOGY

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Insulin resistance, inflammation, and non-alcoholic fatty liver disease

(2008) Herbert Tilg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease

(2008) Xiao-Dong Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY