Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms

Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease

(2016) Sabah Hussain et al.   International Journal of Chronic Obstructive Pulmonary Disease

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer

(2015) Lydia Kriegl et al.   Oncotarget

Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells

(2013) Hilary M Collins et al.   BMC CANCER

SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin

(2012) Il-Rae Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vivorecovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of sirt-1 expression and autophagy in pancreatic β-cell

(2012) Qiong Wang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes

(2012) Shaobin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Involvement of SIRT1 in hypoxic down-regulation of c-Myc and β-catenin and hypoxic preconditioning effect of polyphenols

(2012) Kyung-Soo Hong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Anti-Aging Effects of Phloridzin, an Apple Polyphenol, on Yeastviathe SOD and Sir2 Genes

(2011) Lan XIANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases

(2011) V. S. Thakur et al.   CARCINOGENESIS

(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells

(2011) S. R. Choudhury et al.   CARCINOGENESIS

(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

(2011) V. Nandakumar et al.   CARCINOGENESIS

Anti-inflammatory effects of [6]-shogaol: Potential roles of HDAC inhibition and HSP70 induction

(2011) Sehwan Shim et al.   FOOD AND CHEMICAL TOXICOLOGY

Epigenetic mechanisms of plant-derived anticancer drugs

(2011) Regine Schneider-Stock   Frontiers in Bioscience-Landmark

Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis

(2011) Pei-Chi Tseng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dietary Polyphenols, Deacetylases and Chromatin Remodeling in Inflammation

(2011) Irfan Rahman et al.   Journal of Nutrigenetics and Nutrigenomics

Autism Spectrum Disorders and Epigenetics

(2011) Daria Grafodatskaya et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

The role of histone acetylation in age-associated memory impairment and Alzheimer’s disease

(2011) Roman Manuel Stilling et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

The Flavonoid Quercetin Modulates the Hallmark Capabilities of Hamster Buccal Pouch Tumors

(2011) Ramamurthi Vidya Priyadarsini et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

(2011) F Wang et al.   ONCOGENE

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts

(2011) Xiaoxia Zhu et al.   PLoS One

Sirtuins: A Family of Proteins With Implications for Human Performance and Exercise Physiology

(2011) Zekine Lappalainen   Research in Sports Medicine

Epigenetic diet: impact on the epigenome and cancer

(2011) Tabitha M Hardy et al.   Epigenomics

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK

(2010) Katarzyna Zygmunt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 and p53, effect on cancer, senescence and beyond

(2010) Jingjie Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Effects of epigallocatechin gallate on regulatory T cell number and function in obese v. lean volunteers

(2010) Jung-Mi Yun et al.   BRITISH JOURNAL OF NUTRITION

Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action

(2010) Subhendu Mukherjee et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells

(2010) Samir Attoub et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure

(2010) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Prevents Epigenetic Silencing of BRCA-1 by the Aromatic Hydrocarbon Receptor in Human Breast Cancer Cells

(2010) Andreas J. Papoutsis et al.   JOURNAL OF NUTRITION

Quercetin's Influence on Exercise Performance and Muscle Mitochondrial Biogenesis

(2010) DAVID C. NIEMAN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Manipulating the brain with epigenetics

(2010) Edward Korzus   NATURE NEUROSCIENCE

Stress and the epigenetic landscape: a link to the pathobiology of human diseases?

(2010) Sarah E. Johnstone et al.   NATURE REVIEWS GENETICS

Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α Expression in experimental stroke

(2010) Hai-rong Zhu et al.   NEUROPHARMACOLOGY

PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4

(2010) I-K Kwon et al.   ONCOGENE

CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer

(2010) A Lujambio et al.   ONCOGENE

Procyanidins from Apples (Malus pumilaMill.) Extend the Lifespan ofCaenorhabditis elegans

(2010) Tadahiro Sunagawa et al.   PLANTA MEDICA

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

(2009) J. Mark Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1–FOXO1 signaling pathway

(2009) Guang-Li Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The epigenetic bottleneck of neurodegenerative and psychiatric diseases

(2009) Farahnaz Sananbenesi et al.   BIOLOGICAL CHEMISTRY

Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of RelA Acetylation

(2009) K.-C. Choi et al.   CANCER RESEARCH

Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1

(2009) Lin Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sirtuin activators

(2009) Francisco J Alcaín et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Epigenetics, oxidative stress, and Alzheimer disease

(2009) Nasser H. Zawia et al.   FREE RADICAL BIOLOGY AND MEDICINE

Downregulation of IGF-IR expression by RNAi inhibits proliferation and enhances chemosensitization of human colon cancer cells

(2009) Kamal Yavari et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

(2009) Ramon Amat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction

(2009) Gabriella Marfe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Persimmon Oligomeric Proanthocyanidins Extend Life Span of Senescence-Accelerated Mice

(2009) Takako Yokozawa et al.   JOURNAL OF MEDICINAL FOOD

Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury

(2009) P.K. Dash et al.   NEUROSCIENCE

HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells

(2009) Yong Wang et al.   NEUROSCIENCE LETTERS

Valproic Acid is Neuroprotective in the Rotenone Rat Model of Parkinson’s Disease: Involvement of α-Synuclein

(2009) Barbara Monti et al.   NEUROTOXICITY RESEARCH

SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

(2009) G Boily et al.   ONCOGENE

Molecular Expression Analysis of β-Naphthoflavone-induced Hepatocellular Tumors in Rats

(2009) Yasuaki Dewa et al.   TOXICOLOGIC PATHOLOGY

Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2

(2008) Koremu K. Meja et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

(2008) Gabriela Suchankova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quercetin augments TRAIL-induced apoptotic death: Involvement of the ERK signal transduction pathway

(2008) Young-Ho Kim et al.   BIOCHEMICAL PHARMACOLOGY

Protective Effect of Persimmon (Diospyros kaki) Peel Proanthocyanidin against Oxidative Damage under H2O2-Induced Cellular Senescence

(2008) Young A Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin Modification

(2008) S. Majid et al.   CANCER RESEARCH

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

(2008) T ABEL et al.   CURRENT OPINION IN PHARMACOLOGY

Modulation of gene methylation by genistein or lycopene in breast cancer cells

(2008) Audrey King-Batoon et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Retracted: Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells

(2008) Nobuyuki Kikuno et al.   INTERNATIONAL JOURNAL OF CANCER

Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates β-Catenin Signaling and NFκB-specific Transcription Activity Leading to MDR1 and Bcl-xLGene Expression and Chemoresistance in Breast Tumor Cells

(2008) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Chalcone Polyphenol Inhibits the Deacetylase Activity of SIRT1 and Cell Growth in HEK293T Cells

(2008) Tomoaki Kahyo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Isoflavones Promote Mitochondrial Biogenesis

(2008) K. A. Rasbach et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The use of diversity profiling to characterize chemical modulators of the histone deacetylases

(2008) Leonard Blackwell et al.   LIFE SCIENCES

Modulation of steroid activity in chronic inflammation: A novel anti-inflammatory role for curcumin

(2008) Saibal Biswas et al.   MOLECULAR NUTRITION & FOOD RESEARCH