Beneficial properties of natural phenols: Highlight on protection against pathological conditions associated with amyloid aggregation

Accumulation of Amyloid-Like Aβ1–42 in AEL (Autophagy–Endosomal–Lysosomal) Vesicles: Potential Implications for Plaque Biogenesis

(2014) Daijun Ling et al.   ASN Neuro

Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation

(2014) Peng-xin Xu et al.   BEHAVIOURAL BRAIN RESEARCH

Metabolism of Flavonoids in Human: A Comprehensive Review

(2014) Zhongjian Chen et al.   CURRENT DRUG METABOLISM

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells

(2014) Meng Wang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway

(2013) Ming-liang Chen et al.   Autophagy

Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP

(2013) Michele F.M. Sciacca et al.   BIOPHYSICAL JOURNAL

Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil

(2013) Javier A. Menendez et al.   CELL CYCLE

Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer’s Disease: A New Approach to Therapy

(2013) Marta Sochocka et al.   CNS & Neurological Disorders-Drug Targets

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

(2013) Massimo Stefani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overview of Metabolism and Bioavailability Enhancement of Polyphenols

(2013) Urszula Lewandowska et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

(2013) Hae-Suk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial

(2013) Elena H Martínez-Lapiscina et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice

(2013) Pengwen Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Curcumin Induces Autophagy via Activating the AMPK Signaling Pathway in Lung Adenocarcinoma Cells

(2013) Kui Xiao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The Effect of Ginkgo biloba on Functional Outcome of Patients with Acute Ischemic Stroke: A Double-blind, Placebo-controlled, Randomized Clinical Trial

(2013) Darioush Savadi Oskouei et al.   Journal of Stroke & Cerebrovascular Diseases

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit

(2013) Luisa Diomede et al.   PLoS One

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Ginkgo biloba extract EGb 761® in the treatment of dementia: a pharmacoeconomic analysis of the Austrian setting

(2013) Michael Rainer et al.   WIENER KLINISCHE WOCHENSCHRIFT

Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus

(2013) Elisabetta Borchi et al.   Redox Biology

Bioavailability of Polyphenol Liposomes: A Challenge Ahead

(2013) Nathalie Mignet et al.   Pharmaceutics

Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

(2012) Kwok Kin Cheng et al.   AAPS Journal

Autophagy, polyphenols and healthy ageing

(2012) Kathrin Pallauf et al.   AGEING RESEARCH REVIEWS

Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition

(2012) Nelson Ferreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oleuropein, an Anti-oxidant Polyphenol Constituent of Olive Promotes α-Secretase Cleavage of the Amyloid Precursor Protein (AβPP)

(2012) Myrta Kostomoiri et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Green tea halts progression of cardiac transthyretin amyloidosis: an observational report

(2012) Arnt V. Kristen et al.   Clinical Research in Cardiology

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Protection by Polyphenols of Postprandial Human Plasma and Low-Density Lipoprotein Modification: The Stomach as a Bioreactor

(2012) Joseph Kanner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg

(2012) Horst Herrschaft et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial

(2012) Bruno Vellas et al.   LANCET NEUROLOGY

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Habitual intake of dietary flavonoids and risk of Parkinson disease

(2012) X. Gao et al.   NEUROLOGY

Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila

(2012) Ina Caesar et al.   PLoS One

Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila

(2012) Iain Rogers et al.   PLoS One

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan

(2011) Ehab H. Sarsour et al.   AGE

Clinical trials of resveratrol

(2011) Ketan R. Patel et al.   Annals of the New York Academy of Sciences

Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease

(2011) Dong-Young Choi et al.   BRAIN RESEARCH BULLETIN

Aβ(1-42) Aggregates into Non-Toxic Amyloid Assemblies in the Presence of the Natural Polyphenol Oleuropein Aglycon

(2011) Stefania Rigacci et al.   Current Alzheimer Research

The Role of Phytochemicals in the Treatment and Prevention of Dementia

(2011) Melanie-Jayne R. Howes et al.   DRUGS & AGING

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

(2011) Nelson Ferreira et al.   FEBS LETTERS

Modeling human neurodegenerative diseases in transgenic systems

(2011) Miguel A. Gama Sosa et al.   HUMAN GENETICS

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

(2011) Derliz Mereles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake

(2011) Aida Serra et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Effect of Phenolic Compounds Against Aβ Aggregation and Aβ-Induced Toxicity in Transgenic C. elegans

(2011) Seema Jagota et al.   NEUROCHEMICAL RESEARCH

Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population

(2010) C. C. Tangney et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis

(2010) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

(2010) Marie Daval et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment

(2010) Giuseppe Filomeni et al.   Autophagy

The Crystal Structure of the Green Tea Polyphenol (−)-Epigallocatechin Gallate−Transthyretin Complex Reveals a Novel Binding Site Distinct from the Thyroxine Binding Site,

(2010) Masanori Miyata et al.   BIOCHEMISTRY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

REVIEW: Curcumin and Alzheimer's Disease

(2010) Tsuyoshi Hamaguchi et al.   CNS Neuroscience & Therapeutics

Antioxidant Activities of Hydroxytyrosol Main Metabolites Do Not Contribute to Beneficial Health Effects after Olive Oil Ingestion

(2010) O. Khymenets et al.   DRUG METABOLISM AND DISPOSITION

Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity

(2010) Tae Hyung Kim et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemoprevention

(2010) Sandra Rocha et al.   Nanomedicine

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Alpha-tocopherol quinone inhibits beta-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines

(2010) Shi-gao Yang et al.   NEUROCHEMISTRY INTERNATIONAL

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

(2009) Tsuyoshi Hamaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of curcumin on the amyloid fibrillogenesis of hen egg-white lysozyme

(2009) Steven S.-S. Wang et al.   BIOPHYSICAL CHEMISTRY

Olive Oil and Cognition: Results from the Three-City Study

(2009) Claudine Berr et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin☆

(2009) Stefania Rigacci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Stability of oleuropein in the human proximal gut

(2009) Constantinos Markopoulos et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Consumption of Grape Seed Extract Prevents Amyloid-β Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse

(2009) Yan-Jiang Wang et al.   NEUROTOXICITY RESEARCH

Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure

(2009) M. Servili et al.   INFLAMMOPHARMACOLOGY

Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features

(2008) Yoshiari Shimmyo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nonspecific Interaction of Prefibrillar Amyloid Aggregates with Glutamatergic Receptors Results in Ca2+Increase in Primary Neuronal Cells

(2008) Francesca Pellistri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG

(2007) Hye-Kyung Na et al.   FOOD AND CHEMICAL TOXICOLOGY