Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells

Cross-talk between GPER and growth factor signaling

(2013) Rosamaria Lappano et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mediterranean Dietary Pattern and Risk of Breast Cancer

(2013) Elisabeth Couto et al.   PLoS One

4-Hydroxytamoxifen-stimulated processing of cyclin E is mediated via G protein-coupled receptor 30 (GPR30) and accompanied by enhanced migration in MCF-7 breast cancer cells

(2013) Yang Li et al.   TOXICOLOGY

Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells

(2013) A Chimento et al.   Cell Death & Disease

Heregulin-β1-induced GPR30 upregulation promotes the migration and invasion potential of SkBr3 breast cancer cells via ErbB2/ErbB3–MAPK/ERK pathway

(2012) Shu-Qin Ruan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy

(2012) Rainer Girgert et al.   BREAST CANCER RESEARCH AND TREATMENT

Biomarkers for the clinical management of breast cancer: International perspective

(2012) Neill Patani et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting Estrogen Receptor-α Reduces Adrenocortical Cancer (ACC) Cell Growthin Vitroandin Vivo: Potential Therapeutic Role of Selective Estrogen Receptor Modulators (SERMs) for ACC Treatment

(2012) Rosa Sirianni et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line

(2012) Adele Chimento et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Potential of olive oil phenols as chemopreventive and therapeutic agents against cancer: A review of in vitro studies

(2012) Ivan Casaburi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer

(2011) Atanas Ignatov et al.   BREAST CANCER RESEARCH AND TREATMENT

GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells

(2011) Adele Vivacqua et al.   BREAST CANCER RESEARCH AND TREATMENT

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Olive oil, an essential component of the Mediterranean diet, and breast cancer

(2011) Eduard Escrich et al.   PUBLIC HEALTH NUTRITION

The G Protein-Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor-Positive Breast Cancer Cells

(2010) E. A. Ariazi et al.   CANCER RESEARCH

Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21 and induction of G2 cell-cycle arrest

(2010) Q K Y Chan et al.   CELL DEATH AND DIFFERENTIATION

Gper and ESRs are expressed in rat round spermatids and mediate oestrogen-dependent rapid pathways modulating expression of cyclin B1 and Bax

(2010) A. Chimento et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

17β-Estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ERα

(2010) Adele Chimento et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells

(2010) Rosamaria Lappano et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulation of ERRα Gene Expression by Estrogen Receptor Agonists and Antagonists in SKBR3 Breast Cancer Cells: Differential Molecular Mechanisms Mediated by G Protein-Coupled Receptor GPR30/GPER-1

(2010) Yin Li et al.   MOLECULAR ENDOCRINOLOGY

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Hydroxytyrosol: from laboratory investigations to future clinical trials

(2010) Sergio Granados-Principal et al.   NUTRITION REVIEWS

Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30

(2009) Qingming Ding et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells

(2009) Atanas Ignatov et al.   BREAST CANCER RESEARCH AND TREATMENT

Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells

(2009) Junkyu Han et al.   CYTOTECHNOLOGY

The unfolding stories of GPR30, a new membrane-bound estrogen receptor

(2009) Marcello Maggiolini et al.   JOURNAL OF ENDOCRINOLOGY

Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation

(2009) Rosa Sirianni et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The G Protein-Coupled Receptor GPR30 Inhibits Human Urothelial Cell Proliferation

(2008) Jian Teng et al.   ENDOCRINOLOGY

Epidermal Growth Factor Induces G Protein-Coupled Receptor 30 Expression in Estrogen Receptor-Negative Breast Cancer Cells

(2008) Lidia Albanito et al.   ENDOCRINOLOGY

The Novel Estrogen Receptor, G Protein-Coupled Receptor 30, Mediates the Proliferative Effects Induced by 17β-Estradiol on Mouse Spermatogonial GC-1 Cell Line

(2008) Rosa Sirianni et al.   ENDOCRINOLOGY

Retracted: G-Protein–Coupled Receptor 30 and Estrogen Receptor-α Are Involved in the Proliferative Effects Induced by Atrazine in Ovarian Cancer Cells

(2008) Lidia Albanito et al.   ENVIRONMENTAL HEALTH PERSPECTIVES