Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy
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Title
Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy
Authors
Keywords
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Journal
CHEMICAL REVIEWS
Volume -, Issue -, Pages -
Publisher
American Chemical Society (ACS)
Online
2022-02-03
DOI
10.1021/acs.chemrev.1c00750
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- Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses
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- Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
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- Engineering synthetic vaccines using cues from natural immunity
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- Delivery materials for siRNA therapeutics
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- Enpp1: A Potential Facilitator of Breast Cancer Bone Metastasis
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- Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides
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- Liposome: classification, preparation, and applications
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- PD-1 Expression on Peripheral Blood Cells Increases with Stage in Renal Cell Carcinoma Patients and Is Rapidly Reduced after Surgical Tumor Resection
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- Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling
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- Extremely potent immunotherapeutic activity of a STING agonist in the B16 melanoma model in vivo
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- Biological role of connexin intercellular channels and hemichannels
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- The mammalian PYHIN gene family: Phylogeny, evolution and expression
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- Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
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- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
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- Induction of type I IFNs by intracellular DNA-sensing pathways
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- The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
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- 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential
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- Factors affecting the pharmacokinetics and pharmacodynamics of liposomal drugs
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- Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
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- The structural basis for the sensing and binding of cyclic di-GMP by STING
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- Interferon- mediates chemokine-dependent recruitment of natural killer cells during viral infection
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- Beyond Oil and Water--Phase Transitions in Cells
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- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
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- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
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- STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
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- The mechanism of the anticancer function of M1 macrophages and their use in the clinic
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- Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles
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- Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
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- Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity
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- Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation
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- Identification and characterization of a loss-of-function human MPYS variant
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- Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
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- The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity
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- Chitosan but Not Chitin Activates the Inflammasome by a Mechanism Dependent upon Phagocytosis
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- Randomized Phase III Placebo-Controlled Trial of Carboplatin and Paclitaxel With or Without the Vascular Disrupting Agent Vadimezan (ASA404) in Advanced Non–Small-Cell Lung Cancer
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- Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells
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- Type I interferon is selectively required by dendritic cells for immune rejection of tumors
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- Differentiation of Effector CD4 T Cell Populations
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- Interferon-α as angiogenesis inhibitor: Learning from tumor models
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- Selective Transcription in Response to an Inflammatory Stimulus
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- Tumor masses support naive T cell infiltration, activation, and differentiation into effectors
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- Metalloproteins and metal sensing
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- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
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- S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress
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- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
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