A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel
Authors
Keywords
-
Journal
JOURNAL OF GENERAL PHYSIOLOGY
Volume -, Issue -, Pages jgp.201812138
Publisher
Rockefeller University Press
Online
2019-01-17
DOI
10.1085/jgp.201812138
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- LRRC8/VRAC anion channels are required for late stages of spermatid development in mice
- (2018) Jennifer C. Lück et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LRRC8 amino-termini influence pore properties and gating of volume-regulated VRAC anion channels
- (2018) Pingzheng Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function
- (2018) Toshiki Yamada et al. JOURNAL OF GENERAL PHYSIOLOGY
- Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation
- (2018) Yucong Xue et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- The structure and function of cell membranes studied by atomic force microscopy
- (2018) Yan Shi et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
- (2018) Till Stuhlmann et al. Nature Communications
- SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
- (2018) Chen Kang et al. Nature Communications
- Downregulation of Leucine-Rich Repeat-Containing 8A Limits Proliferation and Increases Sensitivity of Glioblastoma to Temozolomide and Carmustine
- (2018) Sebastian Rubino et al. Frontiers in Oncology
- Structure of a volume-regulated anion channel of the LRRC8 family
- (2018) Dawid Deneka et al. NATURE
- Cryo-EM structures of the human volume-regulated anion channel LRRC8
- (2018) Go Kasuya et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure of the human volume regulated anion channel
- (2018) Jennifer M Kefauver et al. eLife
- Leucine-rich repeat containing 8A (LRRC8A) –dependent volume-regulated anion channel activity is dispensable for T-cell development and function
- (2017) Craig D. Platt et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Selective transport of neurotransmitters and –modulators by distinct volume-regulated LRRC8 anion channels
- (2017) Darius Lutter et al. JOURNAL OF CELL SCIENCE
- Leucine-rich repeat-containing 8B protein is associated with the endoplasmic reticulum Ca2+leak in HEK293 cells
- (2017) Arijita Ghosh et al. JOURNAL OF CELL SCIENCE
- Subunit-dependent oxidative stress sensitivity of LRRC8 volume-regulated anion channels
- (2017) Antonella Gradogna et al. JOURNAL OF PHYSIOLOGY-LONDON
- Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes
- (2017) Alexandra L. Schober et al. JOURNAL OF PHYSIOLOGY-LONDON
- When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor
- (2017) Trine L. Toft-Bertelsen et al. JOURNAL OF PHYSIOLOGY-LONDON
- SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis
- (2017) Yanhui Zhang et al. NATURE CELL BIOLOGY
- Stable membrane orientations of small dual-topology membrane proteins
- (2017) Nir Fluman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular stretching modulates mechanosensing pathways
- (2017) Xian Hu et al. PROTEIN SCIENCE
- Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance
- (2017) Jonas Friard et al. Frontiers in Pharmacology
- Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes
- (2016) Héctor Gaitán-Peñas et al. BIOPHYSICAL JOURNAL
- LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
- (2016) Ruhma Syeda et al. CELL
- Ion channels in regulated cell death
- (2016) Karl Kunzelmann CELLULAR AND MOLECULAR LIFE SCIENCES
- Inactivation and Anion Selectivity of Volume-regulated Anion Channels (VRACs) Depend on C-terminal Residues of the First Extracellular Loop
- (2016) Florian Ullrich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- VRACs and other ion channels and transporters in the regulation of cell volume and beyond
- (2016) Thomas J. Jentsch NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals
- (2016) Lining Ju et al. eLife
- The volume-regulated anion channel is formed by LRRC8 heteromers – molecular identification and roles in membrane transport and physiology
- (2015) Tobias Stauber BIOLOGICAL CHEMISTRY
- Force-Induced Unfolding of Leucine-Rich Repeats of Glycoprotein Ibα Strengthens Ligand Interaction
- (2015) Lining Ju et al. BIOPHYSICAL JOURNAL
- The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema
- (2015) Ravi L. Rungta et al. CELL
- Mechanobiology — chemical origin of membrane mechanical resistance and force-dependent signaling
- (2015) Amy EM Beedle et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs
- (2015) R. Planells-Cases et al. EMBO JOURNAL
- Volume-regulated anion channel—a frenemy within the brain
- (2015) Alexander A. Mongin PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Physiological role of taurine - from organism to organelle
- (2014) I. H. Lambert et al. Acta Physiologica
- SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
- (2014) Zhaozhu Qiu et al. CELL
- The Protein Synthesis Inhibitor Blasticidin S Enters Mammalian Cells via Leucine-rich Repeat-containing Protein 8D
- (2014) Clarissa C. Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function
- (2014) Lalit Kumar et al. JOURNAL OF EXPERIMENTAL MEDICINE
- LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes
- (2014) María C. Hyzinski-García et al. JOURNAL OF PHYSIOLOGY-LONDON
- Characteristics and roles of the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system
- (2014) T. Akita et al. NEUROSCIENCE
- Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC
- (2014) F. K. Voss et al. SCIENCE
- Mechanical Properties of Doubly Stabilized Microtubule Filaments
- (2013) Taviare L. Hawkins et al. BIOPHYSICAL JOURNAL
- CFTR: a hub for kinases and crosstalk of cAMP and Ca2+
- (2013) Karl Kunzelmann et al. FEBS Journal
- Swelling-activated Cl− currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells
- (2013) Wenbin Liang et al. JOURNAL OF HYPERTENSION
- KATP channels and islet hormone secretion: new insights and controversies
- (2013) Frances M. Ashcroft et al. Nature Reviews Endocrinology
- A Reporter Screen in a Human Haploid Cell Line Identifies CYLD as a Constitutive Inhibitor of NF-κB
- (2013) Clarissa C. Lee et al. PLoS One
- LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication
- (2012) Federico Abascal et al. BIOESSAYS
- Molecular Basis of Signaling Specificity of Insulin and IGF Receptors: Neglected Corners and Recent Advances
- (2012) Kenneth Siddle Frontiers in Endocrinology
- Factor for Adipocyte Differentiation 158 Gene Disruption Prevents the Body Weight Gain and Insulin Resistance Induced by a High-Fat Diet
- (2011) Takahiro Hayashi et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes
- (2011) Paul F. Pilch et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Endothelin signalling regulates volume-sensitive Cl− current via NADPH oxidase and mitochondrial reactive oxygen species
- (2010) Wu Deng et al. CARDIOVASCULAR RESEARCH
- Retro-MoRFs: Identifying Protein Binding Sites by Normal and Reverse Alignment and Intrinsic Disorder Prediction
- (2010) Bin Xue et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Naturally occurring organic osmolytes: From cell physiology to disease prevention
- (2010) Shagufta H. Khan et al. IUBMB LIFE
- Control of volume-sensitive chloride channel inactivation by the coupled action of intracellular chloride and extracellular protons
- (2010) Carmen Y. Hernández-Carballo et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Electrical activity in pancreatic islet cells: The VRAC hypothesis
- (2010) Leonard Best et al. Islets
- Studies of the Mechanism of Activation of the Volume-Regulated Anion Channel in Rat Pancreatic β-Cells
- (2009) Len Best et al. JOURNAL OF MEMBRANE BIOLOGY
- Bradykinin-induced astrocyte-neuron signalling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels
- (2009) Hong-Tao Liu et al. JOURNAL OF PHYSIOLOGY-LONDON
- Physiology of Cell Volume Regulation in Vertebrates
- (2009) Else K. Hoffmann et al. PHYSIOLOGICAL REVIEWS
- Cautionary insights on knockout mouse studies: The gene or not the gene?
- (2008) Amy F. Eisener-Dorman et al. BRAIN BEHAVIOR AND IMMUNITY
- The leucine-rich repeat structure
- (2008) J. Bella et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Transient receptor potential A1 mediates an osmotically activated ion channel
- (2008) Xu-Feng Zhang et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra
- (2008) Yonghua Zhang et al. EXPERIMENTAL NEUROLOGY
- Volume-activated chloride channels in mice Leydig cells
- (2008) Luiz Artur Poletto Chaves et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now