Engineered Nanovaccine Targeting Clec9a+ Dendritic Cells Remarkably Enhances the Cancer Immunotherapy Effects of STING Agonist

Prolonged activation of innate immune pathways by a polyvalent STING agonist

(2021) Suxin Li et al.   Nature Biomedical Engineering

Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity

(2020) Ji Wang et al.   SCIENCE

A novel cyclic peptide targeting LAG-3 for cancer immunotherapy by activating antigen-specific CD8+ T cell responses

(2020) Wenjie Zhai et al.   Acta Pharmaceutica Sinica B

A Novel D Peptide Identified by Mirror‐image Phage Display Blocks TIGIT/PVR for Cancer Immunotherapy

(2020) Xiuman Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy

(2020) Chongxian Pan et al.   Journal of Hematology & Oncology

Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma

(2020) Lihong Wang-Bishop et al.   Journal for ImmunoTherapy of Cancer

Lenvatinib plus pembrolizumab in patients with advanced gastric cancer in the first-line or second-line setting (EPOC1706): an open-label, single-arm, phase 2 trial

(2020) Akihito Kawazoe et al.   LANCET ONCOLOGY

Melanoma Peptide MHC Specific TCR Expressing T-Cell Membrane Camouflaged PLGA Nanoparticles for Treatment of Melanoma Skin Cancer

(2020) Serkan Yaman et al.   Frontiers in Bioengineering and Biotechnology

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy

(2020) Hongfei Wang et al.   Journal for ImmunoTherapy of Cancer

Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition

(2020) Yao Li et al.   ACS Nano

In situ activation of STING pathway with polymeric SN38 for cancer chemoimmunotherapy

(2020) Jiayu Zhao et al.   BIOMATERIALS

Enhanced Cancer-targeted Drug Delivery Using Precoated Nanoparticles

(2020) Lu Yu et al.   NANO LETTERS

Addressable Peptide Self-Assembly on the Cancer Cell Membrane for Sensitizing Chemotherapy of Renal Cell Carcinoma

(2019) Ziqi Wang et al.   ADVANCED MATERIALS

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

Intrinsic cancer vaccination

(2019) Yoosoo Yang et al.   ADVANCED DRUG DELIVERY REVIEWS

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

(2019) Anping Li et al.   Journal of Hematology & Oncology

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

STING pathway agonism as a cancer therapeutic

(2019) Blake A. Flood et al.   IMMUNOLOGICAL REVIEWS

Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

(2019) Christina A. Hartl et al.   Journal for ImmunoTherapy of Cancer

Combination of Bacterial‐Photothermal Therapy with an Anti‐PD‐1 Peptide Depot for Enhanced Immunity against Advanced Cancer

(2019) Wenfei Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Bioactive modulators targeting STING adaptor in cGAS-STING pathway

(2019) Xi Feng et al.   DRUG DISCOVERY TODAY

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

(2019) Ryan Zander et al.   IMMUNITY

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination

(2018) Rong Yang et al.   ACS Nano

Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment

(2018) Ruixiang Li et al.   Acta Pharmaceutica Sinica B

T Cell–Inflamed versus Non-T Cell–Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection

(2018) Jonathan A. Trujillo et al.   Cancer Immunology Research

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

Intrinsic Expression of Immune Checkpoint Molecule TIGIT Could Help Tumor Growth in vivo by Suppressing the Function of NK and CD8+ T Cells

(2018) Xiu-Man Zhou et al.   Frontiers in Immunology

33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018)

(2018)   Journal for ImmunoTherapy of Cancer

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

(2016) Haidong Tang et al.   CANCER CELL

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

(2016) Chih-Hang Anthony Tang et al.   CANCER RESEARCH

The host STING pathway at the interface of cancer and immunity

(2016) Leticia Corrales et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy

(2016) Zhongyi Yan et al.   Oncotarget

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

(2016) Tiejun Li et al.   Scientific Reports

Erythrocyte Membrane-Enveloped Polymeric Nanoparticles as Nanovaccine for Induction of Antitumor Immunity against Melanoma

(2015) Yuanyuan Guo et al.   ACS Nano

Blocking of the PD-1/PD-L1 Interaction by aD-Peptide Antagonist for Cancer Immunotherapy

(2015) Hao-Nan Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radiation-Induced IFN-  Production within the Tumor Microenvironment Influences Antitumor Immunity

(2014) A. A. Lugade et al.   JOURNAL OF IMMUNOLOGY

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Engineering synthetic vaccines using cues from natural immunity

(2013) Darrell J. Irvine et al.   NATURE MATERIALS

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

Engineering Approaches to Immunotherapy

(2012) M. A. Swartz et al.   Science Translational Medicine

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

(2009) Y. Lee et al.   BLOOD

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

(2008) David Sancho et al.   JOURNAL OF CLINICAL INVESTIGATION