Chitosan but Not Chitin Activates the Inflammasome by a Mechanism Dependent upon Phagocytosis

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Recognition and Blocking of Innate Immunity Cells by Candida albicans Chitin

(2011) Héctor M. Mora-Montes et al.   INFECTION AND IMMUNITY

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

Human macrophage activation triggered by chitotriosidase-mediated chitin and chitosan degradation

(2010) Christian Gorzelanny et al.   BIOMATERIALS

Chitin induces upregulation of B7-H1 on macrophages and inhibits T-cell proliferation

(2010) Claudia J. Wagner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel chitin and chitosan nanofibers in biomedical applications

(2009) R. Jayakumar et al.   BIOTECHNOLOGY ADVANCES

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal  -Glucan

(2009) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

Chitin Is a Size-Dependent Regulator of Macrophage TNF and IL-10 Production

(2009) C. A. Da Silva et al.   JOURNAL OF IMMUNOLOGY

Bypassing Pathogen‐Induced Inflammasome Activation for the Regulation of Interleukin‐1β Production by the Fungal PathogenCandida albicans

(2009) Frank L. van de Veerdonk et al.   JOURNAL OF INFECTIOUS DISEASES

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chitin, Chitinases and Chitinase-like Proteins in Allergic Inflammation and Tissue Remodeling

(2009) Chun Geun Lee   YONSEI MEDICAL JOURNAL

Chitin nanofibrils for advanced cosmeceuticals

(2008) Pierfrancesco Morganti et al.   CLINICS IN DERMATOLOGY

Chitin regulation of immune responses: an old molecule with new roles

(2008) Chun Geun Lee et al.   CURRENT OPINION IN IMMUNOLOGY

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE