DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

Immunostimulatory role of mitochondrial DAMPs: alarming for pre-eclampsia?

(2016) Cathal Michael McCarthy et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Key Role of DAMP in Inflammation, Cancer, and Tissue Repair

(2016) Franco Pandolfi et al.   CLINICAL THERAPEUTICS

Chemokine regulation of neutrophil function in tumors

(2016) Ornella Bonavita et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Innate immune memory: Implications for host responses to damage-associated molecular patterns

(2016) Tania O. Crișan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

(2016) A. Rialdi et al.   SCIENCE

Decoding the Secret of Cancer by Means of Extracellular Vesicles

(2016) Nobuyoshi Kosaka   Journal of Clinical Medicine

Role of type I interferon in inducing a protective immune response: Perspectives for clinical applications

(2015) Paola Rizza et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Immunity, inflammation, and cancer: an eternal fight between good and evil

(2015) Shabnam Shalapour et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viruses transfer the antiviral second messenger cGAMP between cells

(2015) A. Bridgeman et al.   SCIENCE

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo

(2015) Misako Matsumoto et al.   Nature Communications

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Negative Regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent Antiviral Innate Immune Responses by Arf-like Protein 5B

(2014) Yuichi Kitai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor Efficacy of the Anti-Interleukin-6 (IL-6) Antibody Siltuximab in Mouse Xenograft Models of Lung Cancer

(2014) Lanxi Song et al.   Journal of Thoracic Oncology

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

The chemotherapeutic agent topotecan differentially modulates the phenotype and function of dendritic cells

(2013) Stefanie Trojandt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroptosis

(2013) Jian Zou et al.   IMMUNITY

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

(2012) Marlène Dreux et al.   Cell Host & Microbe

Type I interferon response and innate immune sensing of cancer

(2012) Mercedes B. Fuertes et al.   TRENDS IN IMMUNOLOGY

Anticancer function of polyinosinic-polycytidylic acid

(2011) Yu-sheng Cheng et al.   CANCER BIOLOGY & THERAPY

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response

(2011) J. Fucikova et al.   CANCER RESEARCH

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation

(2010) Fengxiang Wei et al.   CELLULAR SIGNALLING

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

(2010) M. Guescini et al.   EXPERIMENTAL CELL RESEARCH

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Dual Therapeutic Efficacy of Vinblastine as a Unique Chemotherapeutic Agent Capable of Inducing Dendritic Cell Maturation

(2009) H. Tanaka et al.   CANCER RESEARCH

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice

(2008) A Lespagnol et al.   CELL DEATH AND DIFFERENTIATION