Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Authors
Keywords
-
Journal
NATURE IMMUNOLOGY
Volume 17, Issue 10, Pages 1142-1149
Publisher
Springer Nature
Online
2016-09-20
DOI
10.1038/ni.3558
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation
- (2016) Henrique Lemos et al. CANCER RESEARCH
- Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production
- (2016) Warrison A. Andrade et al. Cell Host & Microbe
- Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy
- (2016) Leticia Corrales et al. CYTOKINE
- HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression
- (2016) Maria H Christensen et al. EMBO JOURNAL
- Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response
- (2016) Karen J Mackenzie et al. EMBO JOURNAL
- Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
- (2016) Martin K. Thomsen et al. HEPATOLOGY
- The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA
- (2016) Elizabeth E. Gray et al. IMMUNITY
- RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice
- (2016) Vladislav Pokatayev et al. JOURNAL OF EXPERIMENTAL MEDICINE
- cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection
- (2016) Chan-Wang J. Lio et al. JOURNAL OF VIROLOGY
- Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
- (2016) Qing Chen et al. NATURE
- Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
- (2016) Pengyan Xia et al. NATURE IMMUNOLOGY
- Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS
- (2016) Guigen Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of STING requires palmitoylation at the Golgi
- (2016) Kojiro Mukai et al. Nature Communications
- Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
- (2016) Warrison A. Andrade et al. Cell Reports
- Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis
- (2016) Tianli Xia et al. Cell Reports
- cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells
- (2016) Jennifer Paijo et al. PLoS Pathogens
- Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1
- (2016) Yuko Tsuchiya et al. EBioMedicine
- PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1
- (2015) Sunnie M. Yoh et al. CELL
- STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease
- (2015) Nicole Dobbs et al. Cell Host & Microbe
- The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy
- (2015) Robert O. Watson et al. Cell Host & Microbe
- Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1
- (2015) Ruth Wassermann et al. Cell Host & Microbe
- Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis
- (2015) Angela C. Collins et al. Cell Host & Microbe
- Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein
- (2015) Jian-jun Wu et al. Cell Host & Microbe
- Type I interferonopathies: Mendelian type I interferon up-regulation
- (2015) Yanick J Crow CURRENT OPINION IN IMMUNOLOGY
- Viral RNA detection by RIG-I-like receptors
- (2015) Mitsutoshi Yoneyama et al. CURRENT OPINION IN IMMUNOLOGY
- cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response toFrancisellaInfection
- (2015) Kelly M. Storek et al. JOURNAL OF IMMUNOLOGY
- Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS
- (2015) Feng Ma et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome
- (2015) Elizabeth E. Gray et al. JOURNAL OF IMMUNOLOGY
- Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
- (2015) Anna-Maria Herzner et al. NATURE IMMUNOLOGY
- c-kit+ cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair
- (2015) Qiaozhen Liu et al. NATURE MEDICINE
- STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
- (2015) Olivier Demaria et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
- (2015) Heping Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
- (2015) Daxing Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses
- (2015) Zhe Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Viruses transfer the antiviral second messenger cGAMP between cells
- (2015) A. Bridgeman et al. SCIENCE
- Transmission of innate immune signaling by packaging of cGAMP in viral particles
- (2015) Matteo Gentili et al. SCIENCE
- DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
- (2015) L. Lau et al. SCIENCE
- Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
- (2015) S. Liu et al. SCIENCE
- Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
- (2015) Gil Ju Seo et al. Cell Reports
- Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
- (2015) Leticia Corrales et al. Cell Reports
- TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING
- (2015) Yanming Wang et al. PLoS Pathogens
- Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
- (2014) Qiming Liang et al. Cell Host & Microbe
- Listeria monocytogenes induces IFN expression through an IFI16-, cGAS- and STING-dependent pathway
- (2014) K. Hansen et al. EMBO JOURNAL
- The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING
- (2014) Qiang Wang et al. IMMUNITY
- STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
- (2014) Seng-Ryong Woo et al. IMMUNITY
- STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
- (2014) Liufu Deng et al. IMMUNITY
- The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β duringChlamydia trachomatisInfection
- (2014) Yugen Zhang et al. JOURNAL OF IMMUNOLOGY
- The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
- (2014) Xin Cai et al. MOLECULAR CELL
- Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
- (2014) Lingyin Li et al. Nature Chemical Biology
- Activated STING in a Vascular and Pulmonary Syndrome
- (2014) Yin Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication
- (2014) Randi K. Berg et al. PLoS One
- MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses
- (2014) Ming Zeng et al. SCIENCE
- Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors
- (2014) Surya Pandey et al. Cold Spring Harbor Perspectives in Biology
- The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
- (2014) Xu Zhang et al. Cell Reports
- Anticancer Flavonoids Are Mouse-Selective STING Agonists
- (2013) Sujeong Kim et al. ACS Chemical Biology
- Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
- (2013) Pu Gao et al. CELL
- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
- (2013) Pu Gao et al. CELL
- Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
- (2013) Hiroyasu Konno et al. CELL
- Species-specific detection of the antiviral small-molecule compound CMA by STING
- (2013) Taner Cavlar et al. EMBO JOURNAL
- Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
- (2013) Xin Li et al. IMMUNITY
- The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells
- (2013) Xavier Lahaye et al. IMMUNITY
- Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
- (2013) Nadine Gehrke et al. IMMUNITY
- Immune Sensing of DNA
- (2013) Søren R. Paludan et al. IMMUNITY
- Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses
- (2013) L. Huang et al. JOURNAL OF IMMUNOLOGY
- Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
- (2013) J. Conlon et al. JOURNAL OF IMMUNOLOGY
- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
- (2013) Xu Zhang et al. MOLECULAR CELL
- HIV-1 evades innate immune recognition through specific cofactor recruitment
- (2013) Jane Rasaiyaah et al. NATURE
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- (2013) Andrea Ablasser et al. NATURE
- Structural mechanism of cytosolic DNA sensing by cGAS
- (2013) Filiz Civril et al. NATURE
- Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
- (2013) Andrea Ablasser et al. NATURE
- Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
- (2013) John W. Schoggins et al. NATURE
- Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
- (2013) X.-D. Li et al. SCIENCE
- Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
- (2013) D. Gao et al. SCIENCE
- Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
- (2013) Philip J. Kranzusch et al. Cell Reports
- The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
- (2013) Elie J. Diner et al. Cell Reports
- Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
- (2012) Songying Ouyang et al. IMMUNITY
- Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease
- (2012) Alevtina Gall et al. IMMUNITY
- TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination
- (2012) Jing Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
- (2012) Qian Yin et al. MOLECULAR CELL
- Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
- (2012) Christian K Holm et al. NATURE IMMUNOLOGY
- Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
- (2012) Chang Shu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
- (2012) Guijun Shang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
- (2012) J. Wu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
- (2012) Y. Tanaka et al. Science Signaling
- Type I interferon response and innate immune sensing of cancer
- (2012) Mercedes B. Fuertes et al. TRENDS IN IMMUNOLOGY
- A diverse range of gene products are effectors of the type I interferon antiviral response
- (2011) John W. Schoggins et al. NATURE
- The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
- (2010) Tetsuo Tsuchida et al. IMMUNITY
- Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease: Figure 1
- (2009) Tomas Lindahl et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
- (2009) Yu-Hsin Chiu et al. CELL
- The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA
- (2009) Bo Zhong et al. IMMUNITY
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
- (2009) Hiroki Ishikawa et al. NATURE
- Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
- (2009) T. Saitoh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
- (2008) Bo Zhong et al. IMMUNITY
- TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
- (2008) Ken J. Ishii et al. NATURE
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started