Amplifying STING activation by cyclic dinucleotide–manganese particles for local and systemic cancer metalloimmunotherapy

Prolonged activation of innate immune pathways by a polyvalent STING agonist

(2021) Suxin Li et al.   Nature Biomedical Engineering

Cytosolic Delivery of Thiolated Mn‐cGAMP Nanovaccine to Enhance the Antitumor Immune Responses

(2021) Chengyun Chen et al.   Small

Converting primary tumor towards an in situ STING-activating vaccine via a biomimetic nanoplatform against recurrent and metastatic tumors

(2021) Xue Yang et al.   Nano Today

Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity

(2020) Lin Hou et al.   ACS Nano

Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing

(2020) Nicholas J. Bessman et al.   SCIENCE

NK cells mediate clearance of CD8+ T cell–resistant tumors in response to STING agonists

(2020) Christopher J. Nicolai et al.   Science Immunology

Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery

(2020) Yanpu He et al.   Science Advances

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

T cell stemness and dysfunction in tumors are triggered by a common mechanism

(2019) Suman Kumar Vodnala et al.   SCIENCE

Phase Ib study of MIW815 (ADU-S100) in combination with spartalizumab (PDR001) in patients (pts) with advanced/metastatic solid tumors or lymphomas.

(2019) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

STING pathway agonism as a cancer therapeutic

(2019) Blake A. Flood et al.   IMMUNOLOGICAL REVIEWS

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

(2019) Thomas Scambler et al.   eLife

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

(2019) Linda Schadt et al.   Cell Reports

HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING

(2019) Xiaobo Luo et al.   JOURNAL OF CLINICAL INVESTIGATION

Subcutaneous Nanodisc Vaccination with Neoantigens for Combination Cancer Immunotherapy

(2018) Rui Kuai et al.   BIOCONJUGATE CHEMISTRY

One-pot synthesis of pH-responsive charge-switchable PEGylated nanoscale coordination polymers for improved cancer therapy

(2018) Yu Yang et al.   BIOMATERIALS

Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine

(2018) Yee Sun Tan et al.   CLINICAL CANCER RESEARCH

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Elimination of established tumors with nanodisc-based combination chemoimmunotherapy

(2018) Rui Kuai et al.   Science Advances

LBA15Preliminary results of the first-in-human (FIH) study of MK-1454, an agonist of stimulator of interferon genes (STING), as monotherapy or in combination with pembrolizumab (pembro) in patients with advanced solid tumors or lymphomas

(2018) K J Harrington et al.   ANNALS OF ONCOLOGY

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

(2018) Kelsey E. Sivick et al.   Cell Reports

De-novo and acquired resistance to immune checkpoint targeting

(2017) Nicholas L Syn et al.   LANCET ONCOLOGY

Channelling potassium to fight cancer

(2016) K. George Chandy et al.   NATURE

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

Divalent cation signaling in immune cells

(2014) Benjamin Chaigne-Delalande et al.   TRENDS IN IMMUNOLOGY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D

(2013) B. Chaigne-Delalande et al.   SCIENCE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

Manganese-based MRI contrast agents: past, present, and future

(2011) Dipanjan Pan et al.   TETRAHEDRON

NF- B RelA Subunit Is Crucial for Early IFN-  Expression and Resistance to RNA Virus Replication

(2010) J. Wang et al.   JOURNAL OF IMMUNOLOGY

How the Noninflammasome NLRs Function in the Innate Immune System

(2010) J. P. Y. Ting et al.   SCIENCE