Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
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Title
Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
Authors
Keywords
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Journal
Scientific Reports
Volume 6, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-01-12
DOI
10.1038/srep19049
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- (2014) Daniel T. Fisher et al. SEMINARS IN IMMUNOLOGY
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- (2014) Xu Zhang et al. Cell Reports
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- (2014) Xinyuan Yang et al. Journal of Immunology Research
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