BAF restricts cGAS on nuclear DNA to prevent innate immune activation

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α

(2018) Sinan Kilic et al.   Nature Communications

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

Mechanisms and functions of nuclear envelope remodelling

(2017) Rosemarie Ungricht et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy

(2015) Shouhei Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness

(2015) Takashi Furusawa et al.   Nature Communications

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Detection of Steps in Single Molecule Data

(2011) Tanuj Aggarwal et al.   Cellular and Molecular Bioengineering

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly

(2008) T. Haraguchi et al.   JOURNAL OF CELL SCIENCE