Engineered immunogen binding to alum adjuvant enhances humoral immunity

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

(2018) Colin Havenar-Daughton et al.   Science Translational Medicine

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

(2018) Matteo Bianchi et al.   IMMUNITY

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want

(2018) Harm HogenEsch et al.   npj Vaccines

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem

(2017) Colin Havenar-Daughton et al.   IMMUNOLOGICAL REVIEWS

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

(2017) Daniel W. Kulp et al.   Nature Communications

Impact of adjuvants on CD4 + T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial

(2016) Geert Leroux-Roels et al.   CLINICAL IMMUNOLOGY

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

(2016) Jon M. Steichen et al.   IMMUNITY

Beyond antigens and adjuvants: formulating future vaccines

(2016) Tyson J. Moyer et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro reconstitution of B cell receptor–antigen interactions to evaluate potential vaccine candidates

(2016) Grant C Weaver et al.   Nature Protocols

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

(2016) D. Sok et al.   SCIENCE

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

(2016) J. G. Jardine et al.   SCIENCE

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

(2015) Joyce K. Hu et al.   JOURNAL OF VIROLOGY

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

Analysis of immunoglobulin transcripts and hypermutation following SHIVAD8 infection and protein-plus-adjuvant immunization

(2015) Joseph R. Francica et al.   Nature Communications

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Single-cell based high-throughput sequencing of full-length immunoglobulin heavy and light chain genes

(2013) Christian E. Busse et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1

(2013) Marcella Sarzotti-Kelsoe et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Aluminum Hydroxide Adjuvant Differentially Activates the Three Complement Pathways with Major Involvement of the Alternative Pathway

(2013) Esin Güven et al.   PLoS One

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Control of antigen-binding to aluminum adjuvants and the immune response with a novel phosphonate linker

(2013) Fangjia Lu et al.   VACCINE

Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro

(2012) Tirth R. Ghimire et al.   IMMUNOLOGY LETTERS

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

(2011) Lina E. Tze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alum adjuvant: some of the tricks of the oldest adjuvant

(2011) M. Kool et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Alhydrogel® adjuvant, ultrasonic dispersion and protein binding: A TEM and analytical study

(2011) J. Robin Harris et al.   MICRON

A 2020 vision for vaccines against HIV, tuberculosis and malaria

(2011) Rino Rappuoli et al.   NATURE

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

(2011) Tracy L Flach et al.   NATURE MEDICINE

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

Vaccines with MF59 Adjuvant Expand the Antibody Repertoire to Target Protective Sites of Pandemic Avian H5N1 Influenza Virus

(2010) S. Khurana et al.   Science Translational Medicine

Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response

(2010) Stephanie M. Noe et al.   VACCINE

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Identification and Suppression of β-Elimination Byproducts Arising from the Use of Fmoc-Ser(PO3Bzl,H)-OH in Peptide Synthesis

(2009) Troy J. Attard et al.   International Journal of Peptide Research and Therapeutics

Relationship between tightness of binding and immunogenicity in an aluminum-containing adjuvant-adsorbed hepatitis B vaccine

(2009) Patricia M. Egan et al.   VACCINE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY