Converting primary tumor towards an in situ STING-activating vaccine via a biomimetic nanoplatform against recurrent and metastatic tumors

Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity

(2020) Lin Hou et al.   ACS Nano

Engineering Polymeric Prodrug Nanoplatform for Vaccination Immunotherapy of Cancer

(2020) Lei Zhou et al.   NANO LETTERS

Allosteric coupling between Mn2+ and dsDNA controls the catalytic efficiency and fidelity of cGAS

(2020) Richard M Hooy et al.   NUCLEIC ACIDS RESEARCH

Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti–PD-L1 immunotherapy

(2020) Zhaoting Li et al.   Science Advances

Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines

(2020) Daniel Shae et al.   ACS Nano

Clinical development and potential of photothermal and photodynamic therapies for cancer

(2020) Xingshu Li et al.   Nature Reviews Clinical Oncology

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

(2020) Zhen Zhao et al.   Cell Reports

Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells

(2020) Ling Li et al.   Nature Biomedical Engineering

Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

(2020) Mohammad Ariful Islam et al.   BIOMATERIALS

A nano vector with photothermally enhanced drug release and retention to overcome cancer multidrug resistance

(2020) Chendong Ji et al.   Nano Today

Nanomedicines inhibiting tumor metastasis and recurrence and their clinical applications

(2020) Xiangyi Kong et al.   Nano Today

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy

(2019) Yu-Xue Zhang et al.   NANO LETTERS

Biomimetic Hybrid Nanozymes with Self-Supplied H+ and Accelerated O2 Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors

(2019) Xue Yang et al.   NANO LETTERS

Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial‐Membrane‐Coated Nanoparticles

(2019) Ravi B. Patel et al.   ADVANCED MATERIALS

Self‐Amplified Drug Delivery with Light‐Inducible Nanocargoes to Enhance Cancer Immunotherapy

(2019) Bing Feng et al.   ADVANCED MATERIALS

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

Cell Membrane Coating Nanotechnology

(2018) Ronnie H. Fang et al.   ADVANCED MATERIALS

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

A facile approach to enhance antigen response for personalized cancer vaccination

(2018) Aileen Weiwei Li et al.   NATURE MATERIALS

Photothermal Therapy Generates a Thermal Window of Immunogenic Cell Death in Neuroblastoma

(2018) Elizabeth E. Sweeney et al.   Small

Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer

(2018) Xuejiao Song et al.   NANO LETTERS

Large-Pore Mesoporous-Silica-Coated Upconversion Nanoparticles as Multifunctional Immunoadjuvants with Ultrahigh Photosensitizer and Antigen Loading Efficiency for Improved Cancer Photodynamic Immunotherapy

(2018) Binbin Ding et al.   ADVANCED MATERIALS

Completion of the cytosolic post-chorismate phenylalanine biosynthetic pathway in plants

(2018) Yichun Qian et al.   Nature Communications

Harnessing designed nanoparticles: Current strategies and future perspectives in cancer immunotherapy

(2017) Sung Duk Jo et al.   Nano Today

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

(2017) Veronica Huber et al.   SEMINARS IN CANCER BIOLOGY

Nanomedicine and tumor heterogeneity: Concept and complex reality

(2016) Sandra N. Ekdawi et al.   Nano Today

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses

(2015) Barbara Platzer et al.   Cell Reports

Correction to Multifunctional Albumin–MnO2Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response

(2014) Preethy Prasad et al.   ACS Nano

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Whole Cell Vaccines—Past Progress and Future Strategies

(2012) Bridget P. Keenan et al.   SEMINARS IN ONCOLOGY

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A2

(2009) Jintang Sun et al.   Cellular & Molecular Immunology

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE