Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

(2017) Erkin Erdal et al.   GENES & DEVELOPMENT

Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs

(2017) Martin Achleitner et al.   JOURNAL OF IMMUNOLOGY

Immune Diseases Associated with TREX1 and STING Dysfunction

(2017) Nan Yan   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

(2016) Christine Wolf et al.   Nature Communications

MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

(2016) RaeAnna Wilson et al.   Nature Communications

TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

(2016) Lee Adam Wheeler et al.   Cell Reports

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA

(2015) Fenghua Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Disease Phenotypes Associated With Mutations in TREX1

(2015) Gillian I. Rice et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

(2015) Jessica L. Grieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inosine in DNA and RNA

(2014) Ingrun Alseth et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates

(2014) G. H. Gwon et al.   EMBO JOURNAL

The 3′–5′ DNA Exonuclease TREX1 Directly Interacts with Poly(ADP-ribose) Polymerase-1 (PARP1) during the DNA Damage Response

(2014) Takuya Miyazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

(2014) Sanghee Lee et al.   Nature Chemical Biology

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

Structural Insights Into DNA Repair by RNase T—An Exonuclease Processing 3′ End of Structured DNA in Repair Pathways

(2014) Yu-Yuan Hsiao et al.   PLOS BIOLOGY

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination

(2013) Clinton D. Orebaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endonuclease V: an unusual enzyme for repair of DNA deamination

(2012) Weiguo Cao   CELLULAR AND MOLECULAR LIFE SCIENCES

Endogenous retroelements and autoimmune disease

(2012) Daniel B Stetson   CURRENT OPINION IN IMMUNOLOGY

Human endonuclease V as a repair enzyme for DNA deamination

(2012) Rongjuan Mi et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T–product complexes

(2012) Yu-Yuan Hsiao et al.   NUCLEIC ACIDS RESEARCH

Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease

(2011) Suzanna L. Bailey et al.   DNA REPAIR

Dominant Mutations of the TREX1 Exonuclease Gene in Lupus and Aicardi-Goutières Syndrome

(2011) Jason M. Fye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for RNA trimming by RNase T in stable RNA 3′-end maturation

(2011) Yu-Yuan Hsiao et al.   Nature Chemical Biology

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

New roles for the major human 3′-5′ exonuclease TREX1 in human disease

(2010) David Kavanagh et al.   CELL CYCLE

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage

(2010) Markus Christmann et al.   NUCLEIC ACIDS RESEARCH

A novel single-stranded DNA-specific 3′–5′ exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways

(2010) Atsuhiro Shimada et al.   NUCLEIC ACIDS RESEARCH

Control of genome stability by Slx protein complexes

(2009) John Rouse   BIOCHEMICAL SOCIETY TRANSACTIONS

TREX1 acts in degrading damaged DNA from drug-treated tumor cells

(2009) Chuan-Jen Wang et al.   DNA REPAIR

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

Nucleic acid-mediated inflammatory diseases

(2008) Rachel E. Rigby et al.   BIOESSAYS

Linking Retroelements to Autoimmunity

(2008) Vijay G. Bhoj et al.   CELL

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders

(2008) Mark O’Driscoll   DNA REPAIR

The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease

(2008) Duane A. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY