Oxidative Stress and Beta Amyloid in Alzheimer’s Disease. Which Comes First: The Chicken or the Egg?

Environmental exposures and the etiopathogenesis of Alzheimer's disease: The potential role of BACE1 as a critical neurotoxic target

(2021) Tauqeerunnisa Syeda et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer’s Disease

(2021) Marta Campora et al.   Pharmaceuticals

A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

(2021) Mark F. McCarty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synergistic Effects of APOE and CLU May Increase the Risk of Alzheimer’s Disease: Acceleration of Atrophy in the Volumes and Shapes of the Hippocampus and Amygdala

(2021) Na An et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Acute glucose fluctuation promotes RAGE expression via reactive oxygen species‑mediated NF‑κB activation in rat podocytes

(2021) Zhangjie Hu et al.   Molecular Medicine Reports

(Dys)regulation of Synaptic Activity and Neurotransmitter Release by β-Amyloid: A Look Beyond Alzheimer's Disease Pathogenesis

(2021) Francesca Fagiani et al.   Frontiers in Molecular Neuroscience

Epigenetics of Alzheimer’s Disease

(2021) Matea Nikolac Perkovic et al.   Biomolecules

Metabolic adaptation in hypoxia and cancer

(2021) Felipe Paredes et al.   CANCER LETTERS

AGE/RAGE in diabetic kidney disease and ageing kidney

(2021) Xia-Qing Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Myricetin prevents high molecular weight Aβ1-42 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria

(2021) Atsushi Michael Kimura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of ABCA7 in Human Health and in Alzheimer’s Disease

(2021) Shiraz Dib et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular signal‐regulated kinase regulates microglial immune responses in Alzheimer’s disease

(2021) Michael J. Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

(2021) Abhishek Bhattacherjee et al.   Molecular Neurodegeneration

Oxidative Stress, Neuroinflammation, and NADPH Oxidase: Implications in the Pathogenesis and Treatment of Alzheimer’s Disease

(2021) Upasana Ganguly et al.   Oxidative Medicine and Cellular Longevity

The piperine derivative HJ105 inhibits Aβ1–42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis

(2021) Xiping Yang et al.   PHYTOMEDICINE

Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy

(2021) Michael Tran Duong et al.   Frontiers in Aging Neuroscience

Application of Antibody Fragments Against Aβ With Emphasis on Combined Application With Nanoparticles in Alzheimer’s Disease

(2021) Zhi-Ting Sun et al.   Frontiers in Pharmacology

β-Asarone Ameliorates β-Amyloid–Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway

(2021) Miaomiao Meng et al.   Frontiers in Pharmacology

Brain Glucose Metabolism in Health, Obesity, and Cognitive Decline—Does Insulin Have Anything to Do with It? A Narrative Review

(2021) Eleni Rebelos et al.   Journal of Clinical Medicine

Hypoxia and brain aging: Neurodegeneration or neuroprotection?

(2021) Johannes Burtscher et al.   AGEING RESEARCH REVIEWS

Adalimumab ameliorates memory impairments and neuroinflammation in chronic cerebral hypoperfusion rats

(2021) Jing-Jing Xu et al.   Aging-US

The BIN1 rs744373 Alzheimer's disease risk SNP is associated with faster Aβ‐associated tau accumulation and cognitive decline

(2021) Nicolai Franzmeier et al.   Alzheimers & Dementia

Amyloid-β: A double agent in Alzheimer's disease?

(2021) Hao Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Critical Appraisal of Amyloid Lowering Agents in AD

(2021) Boris Decourt et al.   Current Neurology and Neuroscience Reports

APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention

(2021) Xiaopu Zhou et al.   CURRENT OPINION IN NEUROBIOLOGY

Current Status of Clinical Trials on Tau Immunotherapies

(2021) Changyi Ji et al.   DRUGS

Biomarkers for evaluating the effects of exercise interventions in patients with MCI or dementia: A systematic review and meta-analysis

(2021) Xiuxiu Huang et al.   EXPERIMENTAL GERONTOLOGY

Neuroprotective Function of High Glycolytic Activity in Astrocytes: Common Roles in Stroke and Neurodegenerative Diseases

(2021) Shinichi Takahashi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

(2021) Jinar Rostami et al.   Journal of Neuroinflammation

Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease

(2021) Malin Johannesson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies

(2021) Yuxing Xia et al.   Molecular Neurodegeneration

Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment

(2021) Haruki Koike et al.   MOLECULES

Protective effect of alpha-linoleic acid on Aβ-induced oxidative stress, neuroinflammation, and memory impairment by alteration of α7 nAChR and NMDAR gene expression in the hippocampus of rats

(2021) Nahaleh Tofighi et al.   NEUROTOXICOLOGY

Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89

(2021) Nada H. Ashour et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Chronic ghrelin administration suppresses IKK/NF-κB/BACE1 mediated Aβ production in primary neurons and improves cognitive function via upregulation of PP1 in STZ-diabetic rats

(2020) Lou-Yan Ma et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

(2020) Dominic M Walsh et al.   CURRENT OPINION IN NEUROBIOLOGY

Geraniin Protects PC12 Cells Against Aβ25–35-Mediated Neuronal Damage: Involvement of NF-κB and MAPK Signaling Pathways

(2020) Kumju Youn et al.   JOURNAL OF MEDICINAL FOOD

Chronic Administration of Scopolamine Increased GSK3βP9, Beta Secretase, Amyloid Beta, and Oxidative Stress in the Hippocampus of Wistar Rats

(2020) Maricarmen Hernández-Rodríguez et al.   MOLECULAR NEUROBIOLOGY

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

(2020) Tiantian Guo et al.   Molecular Neurodegeneration

The Pathogenesis Mechanism, Structure Properties, Potential Drugs and Therapeutic Nano-particles Against the Small Oligomers of Amyloid-β

(2020) Ke Wang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel therapeutic strategies for Alzheimer’s disease targeting brain cholesterol homeostasis

(2020) Nikita Patil Samant et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Exploring the Potential of Therapeutic Agents Targeted towards Mitigating the Events Associated with Amyloid-β Cascade in Alzheimer’s Disease

(2020) Tapan Behl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer’s disease and type 2 diabetes mellitus: A systematic review of proteomic studies

(2020) Jessica Diniz Pereira et al.   JOURNAL OF NEUROCHEMISTRY

Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer’s Disease

(2020) Yidan Zhang et al.   NEUROCHEMICAL RESEARCH

Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer’s disease patients

(2020) Risa Mitsumori et al.   PLoS One

The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease

(2020) Kendra L. Hanslik et al.   Frontiers in Neurology

Association between chronic stress and Alzheimer’s disease: Therapeutic effects of Saffron

(2020) Mohammad Saeedi et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of reactive oxygen species in the progression of Alzheimer’s disease

(2020) Shvetank Bhatt et al.   DRUG DISCOVERY TODAY

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease

(2020) Vandana Bhatia et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Medical Hypothesis: Neurodegenerative Diseases Arise from Oxidative Damage to Electron Tunneling Proteins in Mitochondria

(2019) James P. Bennett   MEDICAL HYPOTHESES

Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease

(2019) Niraj Kumar Jha et al.   JOURNAL OF NEUROCHEMISTRY

Safe coordinated trafficking of heme and iron with copper maintain cell homeostasis: modules from the hemopexin system

(2019) R. Vanacore et al.   BIOMETALS

AGE–RAGE stress: a changing landscape in pathology and treatment of Alzheimer’s disease

(2019) Kailash Prasad   MOLECULAR AND CELLULAR BIOCHEMISTRY

An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

(2019) Dominique Detaille et al.   PLoS One

Homomeric and Heteromeric Aβ Species Exist in Human Brain and CSF Regardless of Alzheimer’s Disease Status and Risk Genotype

(2019) Erica Lana et al.   Frontiers in Molecular Neuroscience

Systemic Oxidative Stress: A Key Point in Neurodegeneration — A Review

(2019) E. E. Martínez Leo et al.   Journal of Nutrition Health & Aging

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Stroke and Amyloid-β Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response

(2019) Michela Guglielmotto et al.   JOURNAL OF ALZHEIMERS DISEASE

Regular Exercise Enhances Cognitive Function and Intracephalic GLUT Expression in Alzheimer’s Disease Model Mice

(2019) Ruiqi Pang et al.   JOURNAL OF ALZHEIMERS DISEASE

Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways

(2019) Zhiyun Wei et al.   NEUROBIOLOGY OF DISEASE

Friend, Foe or Both? Immune Activity in Alzheimer’s Disease

(2019) Georgia R. Frost et al.   Frontiers in Aging Neuroscience

Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer’s Disease Hippocampus

(2018) Abhik Sen et al.   JOURNAL OF ALZHEIMERS DISEASE

Heme and hemoglobin suppress amyloid β–mediated inflammatory activation of mouse astrocytes

(2018) Sitara B. Sankar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Molecular subtypes of Alzheimer’s disease

(2018) Giuseppe Di Fede et al.   Scientific Reports

Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease

(2018) Ming-Che Lee et al.   Scientific Reports

A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1

(2018) Gabriella Testa et al.   Redox Biology

Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review

(2018) Erwin Lemche   CURRENT GENOMICS

Amyloid-β Metabolite Sensing: Biochemical Linking of Glycation Modification and Misfolding

(2018) Janelle N. Fawver et al.   JOURNAL OF ALZHEIMERS DISEASE

Association between Stroke and Alzheimer's Disease: Systematic Review and Meta-Analysis

(2018) Jing Zhou et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurovascular dysfunction in vascular dementia, Alzheimer’s and atherosclerosis

(2018) Osman Shabir et al.   BMC NEUROSCIENCE

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer’s disease

(2018) Shaomin Li et al.   Acta Neuropathologica Communications

The interaction of zinc and the blood-brain barrier under physiological and ischemic conditions

(2018) Zhifeng Qi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Early-Onset Alzheimer Disease

(2017) Mario F. Mendez   NEUROLOGIC CLINICS

Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice

(2017) Rajib Paul et al.   Scientific Reports

Comorbidity and progression of late onset Alzheimer’s disease: A systematic review

(2017) Miriam L. Haaksma et al.   PLoS One

The Role of Mitochondrial Dysfunction in the Progression of Alzheimer’s Disease

(2017) Claus Desler et al.   CURRENT MEDICINAL CHEMISTRY

Iron uptake and transport across physiological barriers

(2016) Kari A. Duck et al.   BIOMETALS

The Pathophysiology of Heme in the Brain

(2016) Raffaella Gozzelino   Current Alzheimer Research

Insulin signalling in Alzheimer′s disease and diabetes: from epidemiology to molecular links

(2016) E. M. Ribe et al.   JOURNAL OF INTERNAL MEDICINE

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease

(2016) J.-S. Zhang et al.   NEUROSCIENCE

Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide

(2016) Valentina Villa et al.   PHARMACOLOGICAL RESEARCH

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug development in Alzheimer’s disease: the path to 2025

(2016) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Alzheimer’s Disease: A Heme–Aβ Perspective

(2015) Chandradeep Ghosh et al.   ACCOUNTS OF CHEMICAL RESEARCH

Oxidative stress and lipid peroxidation are upstream of amyloid pathology

(2015) Muriel Arimon et al.   NEUROBIOLOGY OF DISEASE

The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-βProduction in Alzheimer’s Disease

(2015) Li Zuo et al.   Oxidative Medicine and Cellular Longevity

Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect ofN-acetyl-cysteine

(2014) Paola Gamba et al.   AGING CELL

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

(2014) Frederic Brosseron et al.   MOLECULAR NEUROBIOLOGY

An anemia of Alzheimer's disease

(2014) N G Faux et al.   MOLECULAR PSYCHIATRY

Multiple Mechanisms of Iron-Induced Amyloid Beta-Peptide Accumulation in SHSY5Y Cells: Protective Action of Negletein

(2014) Priyanjalee Banerjee et al.   NEUROMOLECULAR MEDICINE

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

(2014) Pasquale Picone et al.   Oxidative Medicine and Cellular Longevity

Heme, an Essential Nutrient from Dietary Proteins, Critically Impacts Diverse Physiological and Pathological Processes

(2014) Jagmohan Hooda et al.   Nutrients

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

(2014) Ya-Ting Chang et al.   Biomed Research International

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

(2014) Enrique Blázquez et al.   Frontiers in Endocrinology

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Unraveling the complex metabolic nature of astrocytes

(2013) Anne-Karine Bouzier-Sore et al.   Frontiers in Cellular Neuroscience

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications

(2011) Ravichandran Ramasamy et al.   Annals of the New York Academy of Sciences

Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases

(2011) Z. Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease

(2011) Xiulian Sun et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of Amyloid-  (A ) Peptide-Binding Alcohol Dehydrogenase-A  Interaction Reduces A  Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease

(2011) J. Yao et al.   JOURNAL OF NEUROSCIENCE

Reactive Metabolites and AGE/RAGE-Mediated Cellular Dysfunction Affect the Aging Process – A Mini-Review

(2010) Thomas H. Fleming et al.   GERONTOLOGY

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

(2010) Andrei G. Vlassenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Inhibition of γ-secretase activity reduces Aβ production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease

(2009) Baiyang Sheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutant Presenilin 1 Increases the Expression and Activity of BACE1

(2009) Luca Giliberto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine Glut-1 transporter haploinsufficiency: Postnatal deceleration of brain weight and reactive astrocytosis

(2009) Paivi M. Ullner et al.   NEUROBIOLOGY OF DISEASE

DNA damage-inducing agents elicit γ-secretase activation mediated by oxidative stress

(2008) S M Jin et al.   CELL DEATH AND DIFFERENTIATION

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain

(2008) Li-Hong Zhang et al.   NEUROBIOLOGY OF AGING

Evidence that γ-secretase mediates oxidative stress-induced β-secretase expression in Alzheimer's disease

(2008) Dong-Gyu Jo et al.   NEUROBIOLOGY OF AGING

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

(2007) Liang Li et al.   NEUROBIOLOGY OF AGING