Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy
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Title
Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy
Authors
Keywords
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Journal
Frontiers in Aging Neuroscience
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-03-25
DOI
10.3389/fnagi.2021.647990
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Note: Only part of the references are listed.- APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function
- (2021) Monica Xiong et al. Science Translational Medicine
- Alzheimer’s Disease and Vascular Aging
- (2020) Marta Cortes-Canteli et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease
- (2020) Tosha Williams et al. Molecular Neurodegeneration
- Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
- (2020) Julia Marschallinger et al. NATURE NEUROSCIENCE
- TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
- (2020) Alicia A. Nugent et al. NEURON
- APOE4 Accelerates Development of Dementia After Stroke
- (2020) Axel Montagne et al. STROKE
- APOE-ε4 Genotype and Dementia Before and After Transient Ischemic Attack and Stroke
- (2020) Sarah T. Pendlebury et al. STROKE
- Intracranial Atherosclerosis Treatment
- (2020) Brent Flusty et al. STROKE
- Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
- (2020) Eric M. Reiman et al. Nature Communications
- Low-Density Lipoprotein Cholesterol and Alzheimer's Disease: A Systematic Review and Meta-Analysis
- (2020) Zhike Zhou et al. Frontiers in Aging Neuroscience
- Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects
- (2020) Tamas Kiss et al. GeroScience
- Revisiting atherosclerosis and dementia
- (2020) Costantino Iadecola NATURE NEUROSCIENCE
- Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain
- (2020) Aliza P. Wingo et al. NATURE NEUROSCIENCE
- Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas
- (2020) Alma Zernecke et al. CIRCULATION RESEARCH
- Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes
- (2020) Joel W. Blanchard et al. NATURE MEDICINE
- Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
- (2020) Benjamin J. Andreone et al. NATURE NEUROSCIENCE
- Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop
- (2020) Berislav V. Zlokovic et al. Alzheimers & Dementia
- Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study)
- (2020) Jessica Sarahi Alavez-Rubio et al. MOLECULAR NEUROBIOLOGY
- Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease
- (2020) Shun-Fat Lau et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4
- (2020) Priyanka Narayan et al. Cell Reports
- APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches
- (2020) Alberto Serrano-Pozo et al. LANCET NEUROLOGY
- The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease
- (2019) Celia G. Fernandez et al. Frontiers in Aging Neuroscience
- Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
- (2019) Rik van der Kant et al. Cell Stem Cell
- Association of Early-Onset Alzheimer Disease With Elevated Low-density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB
- (2019) Thomas S. Wingo et al. JAMA Neurology
- Vascular Cognitive Impairment and Dementia
- (2019) Costantino Iadecola et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Trajectories of Blood Lipid Concentrations Over the Adult Life Course and Risk of Cardiovascular Disease and All‐Cause Mortality: Observations From the Framingham Study Over 35 Years
- (2019) Meredith S. Duncan et al. Journal of the American Heart Association
- Epidemiology of Vascular Dementia
- (2019) Frank J. Wolters et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions
- (2019) et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions
- (2019) Elaina M. Melton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging
- (2019) Stefano Tarantini et al. GeroScience
- Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway
- (2019) Junxiang Yin et al. Aging-US
- Association of Intracranial Atherosclerotic Disease With Brain β-Amyloid Deposition
- (2019) Rebecca F. Gottesman et al. JAMA Neurology
- Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study
- (2018) Olivia A. Skrobot et al. Alzheimers & Dementia
- NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
- (2018) Clifford R. Jack et al. Alzheimers & Dementia
- Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance
- (2018) Clément Cochain et al. CIRCULATION RESEARCH
- Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass CytometryNovelty and Significance
- (2018) Holger Winkels et al. CIRCULATION RESEARCH
- An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia
- (2018) Brittani R. Price et al. JOURNAL OF NEUROCHEMISTRY
- Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
- (2018) Chengzhong Wang et al. NATURE MEDICINE
- APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
- (2018) Yuan-Ta Lin et al. NEURON
- Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages
- (2018) Evan D. Muse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics
- (2018) Jan Verheijen et al. TRENDS IN GENETICS
- Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis
- (2018) Che-Sheng Chu et al. Scientific Reports
- Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau
- (2018) Timothy J. Hohman et al. JAMA Neurology
- Absolute 10-year risk of dementia by age, sex andAPOEgenotype: a population-based cohort study
- (2018) Katrine L. Rasmussen et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
- Mechanisms of Vascular Aging
- (2018) Zoltan Ungvari et al. CIRCULATION RESEARCH
- Statins and Vascular Dementia: A Review
- (2018) Sotirios Giannopoulos et al. JOURNAL OF ALZHEIMERS DISEASE
- Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
- (2018) Kenzo Koizumi et al. Nature Communications
- APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults
- (2018) Melissa Lamar et al. Alzheimers & Dementia
- Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease
- (2018) M. Tzioras et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
- (2018) Changjun Yang et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis
- (2017) Kaarin J. Anstey et al. JOURNAL OF ALZHEIMERS DISEASE
- Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
- (2017) Antoine Louveau et al. JOURNAL OF CLINICAL INVESTIGATION
- Polymorphisms of MTHFR , eNOS , ACE , AGT , ApoE , PON1 , PDE4D , and Ischemic Stroke: Meta-Analysis
- (2017) Loo Keat Wei et al. Journal of Stroke & Cerebrovascular Diseases
- Intracranial atherosclerosis and dementia
- (2017) Jennifer L. Dearborn et al. NEUROLOGY
- Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis
- (2017) Tien-Phat V. Huynh et al. NEURON
- Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease
- (2017) Nophar Geifman et al. Alzheimers Research & Therapy
- Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
- (2017) Hansruedi Mathys et al. Cell Reports
- Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study
- (2017) Claudia K. Suemoto et al. PLOS MEDICINE
- Polymorphisms of MTHFR , eNOS , ACE , AGT , ApoE , PON1 , PDE4D , and Ischemic Stroke: Meta-Analysis
- (2017) Loo Keat Wei et al. Journal of Stroke & Cerebrovascular Diseases
- Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease
- (2017) Scott C. Neu et al. JAMA Neurology
- Racial Differences in Prevalence and Risk for Intracranial Atherosclerosis in a US Community-Based Population
- (2017) Ye Qiao et al. JAMA Cardiology
- Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review
- (2016) Katrine Laura Rasmussen ATHEROSCLEROSIS
- Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils
- (2016) Todd G. Kirchgessner et al. Cell Metabolism
- Animal Models of Vascular Cognitive Impairment and Dementia (VCID)
- (2016) Jennifer Gooch et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
- (2016) Yu Yamazaki et al. CNS DRUGS
- Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression
- (2016) Li-Hao Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease
- (2015) Liv Tybjærg Nordestgaard et al. Alzheimers & Dementia
- ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease
- (2015) Yohei Shibuya et al. Future Medicinal Chemistry
- Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators
- (2015) Maximillian A. Rogers et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage
- (2015) Yohei Shibuya et al. NEUROBIOLOGY OF AGING
- Astrocyte Regulation of Blood Flow in the Brain
- (2015) Brian A. MacVicar et al. Cold Spring Harbor Perspectives in Biology
- Cause and Mechanisms of Intracranial Atherosclerosis
- (2014) Katja Ritz et al. CIRCULATION
- Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases A 1-42 Clearance
- (2014) Y. Shibuya et al. JOURNAL OF NEUROSCIENCE
- Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis
- (2014) Xue-Qing Zhang et al. Advanced Healthcare Materials
- Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature
- (2014) Richard Lathe et al. BMC Geriatrics
- Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function
- (2014) Angel C. Y. Mak et al. JAMA Neurology
- Risk factors for dementia with type 2 diabetes mellitus among elderly people in China
- (2013) M. Fei et al. AGE AND AGEING
- APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature
- (2013) Peter T. Nelson et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Statins and Cognitive Decline in Older Adults with Normal Cognition or Mild Cognitive Impairment
- (2013) Kyle Steenland et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
- (2013) Chia-Chen Liu et al. Nature Reviews Neurology
- Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
- (2012) M. Yarchoan et al. BRAIN
- Aging and Atherosclerosis
- (2012) Julie C. Wang et al. CIRCULATION RESEARCH
- Small-Molecule Structure Correctors Target Abnormal Protein Structure and Function: Structure Corrector Rescue of Apolipoprotein E4–Associated Neuropathology
- (2012) Robert W. Mahley et al. JOURNAL OF MEDICINAL CHEMISTRY
- Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
- (2012) Robert D. Bell et al. NATURE
- Intracranial atherosclerosis as a contributing factor to Alzheimer’s disease dementia
- (2011) Alex E. Roher et al. Alzheimers & Dementia
- Cholesterol Level and Statin Use in Alzheimer Disease
- (2011) Nina E. Shepardson ARCHIVES OF NEUROLOGY
- Cholesterol Level and Statin Use in Alzheimer Disease
- (2011) Nina E. Shepardson ARCHIVES OF NEUROLOGY
- Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease
- (2011) Robin B. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Labeled Acetate as a Marker of Astrocytic Metabolism
- (2011) Matthias T Wyss et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis
- (2011) Marc I. Chimowitz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Vascular Contributions to Cognitive Impairment and Dementia
- (2011) Philip B. Gorelick et al. STROKE
- Higher Incidence of Mild Cognitive Impairment in Familial Hypercholesterolemia
- (2010) Daniel Zambón et al. AMERICAN JOURNAL OF MEDICINE
- Atherosclerosis, dementia, and alzheimer's disease in the BLSA cohort
- (2010) Hillary Dolan et al. ANNALS OF NEUROLOGY
- Liver X Receptor Signaling Pathways and Atherosclerosis
- (2010) Anna C. Calkin et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Association between APOE ε4 Allele and Vascular Dementia: The Cache County Study
- (2010) Yi-Fang Chuang et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Glial and neuronal control of brain blood flow
- (2010) David Attwell et al. NATURE
- The 32-year relationship between cholesterol and dementia from midlife to late life
- (2010) M. M. Mielke et al. NEUROLOGY
- ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD
- (2010) E. Y. Bryleva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
- (2010) D. A. Wolk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acyl-coenzyme A:cholesterol acyltransferases
- (2009) Ta-Yuan Chang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Apolipoprotein E receptors in the nervous system
- (2009) Joachim Herz CURRENT OPINION IN LIPIDOLOGY
- Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later
- (2009) Alina Solomon et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Lipids' peroxidation markers in Alzheimer's disease and vascular dementia
- (2009) Katarzyna Gustaw-Rothenberg et al. Geriatrics & Gerontology International
- Systemic inflammation and disease progression in Alzheimer disease
- (2009) C. Holmes et al. NEUROLOGY
- The Role of Apolipoprotein E in Alzheimer's Disease
- (2009) Jungsu Kim et al. NEURON
- Associations of apolipoprotein E gene with ischemic stroke and intracranial atherosclerosis
- (2008) Shérine Abboud et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease
- (2007) Marit Granér et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
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