APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention

Apolipoprotein E promotes white matter remodeling via the Dab1‐dependent pathway after traumatic brain injury

(2020) Zhi‐Jian Huang et al.   CNS Neuroscience & Therapeutics

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease

(2020) Dana M. Cairns et al.   Science Advances

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

(2020) Joel W. Blanchard et al.   NATURE MEDICINE

Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

(2020) Karpagam Srinivasan et al.   Cell Reports

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

(2019) Changjun Yin et al.   NATURE MEDICINE

Single-cell genomics identifies cell type–specific molecular changes in autism

(2019) Dmitry Velmeshev et al.   SCIENCE

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

(2019) Yu-Wen Alvin Huang et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

(2019) Ramsey Najm et al.   Molecular Neurodegeneration

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

(2019) Xiaopu Zhou et al.   Nature Communications

Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond

(2019) Elena V. Fuior et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

Haplotype analysis of APOE intragenic SNPs

(2018) Vladimir N. Babenko et al.   BMC NEUROSCIENCE

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

(2018) Fan Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

(2018) Chengzhong Wang et al.   NATURE MEDICINE

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer’s disease

(2018) Jolanta Bratosiewicz-Wasik et al.   NEUROSCIENCE LETTERS

Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis

(2018) Xiaopu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein-E (Apoe) ε4 and cognitive decline over the adult life course

(2018) Mark James Rawle et al.   Translational Psychiatry

Herpes viruses and Alzheimer's disease: new evidence in the debate

(2018) Brian J Balin et al.   LANCET NEUROLOGY

Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan

(2018) RyanJ Piers   Neural Regeneration Research

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

(2018) Farid Rajabli et al.   PLoS Genetics

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease

(2017) Veena Theendakara et al.   MOLECULAR NEUROBIOLOGY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease

(2017) Valentina Escott-Price et al.   NEUROBIOLOGY OF AGING

Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers

(2017) Kaitlin B. Casaletto et al.   NEUROLOGY

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

(2017) Tien-Phat V. Huynh et al.   NEURON

Multiple SNPs Within and Surrounding the Apolipoprotein E Gene Influence Cerebrospinal Fluid Apolipoprotein E Protein Levels

(2017) Lynn M. Bekris et al.   JOURNAL OF ALZHEIMERS DISEASE

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Direct Transcriptional Effects of Apolipoprotein E

(2016) V. Theendakara et al.   JOURNAL OF NEUROSCIENCE

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice

(2016) C. Lane-Donovan et al.   JOURNAL OF NEUROSCIENCE

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

(2016) Giuseppe Lo Sasso et al.   Journal of Translational Medicine

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease

(2015) Ann De Vos et al.   Alzheimers & Dementia

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Characterization of a Novel DWD Protein that Participates in Heat Stress Response in Arabidopsis

(2014) Soon-Hee Kim et al.   MOLECULES AND CELLS

Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

(2014) Yadong Huang et al.   NEUROBIOLOGY OF DISEASE

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

(2014) Angel C. Y. Mak et al.   JAMA Neurology

Epigenetic signature and enhancer activity of the human APOE gene

(2013) Chang-En Yu et al.   HUMAN MOLECULAR GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

The forgotten APOE allele: A review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2

(2013) Sana Suri et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Macrophage-Specific ApoE Gene Repair Reduces Diet-Induced Hyperlipidemia and Atherosclerosis in Hypomorphic Apoe Mice

(2012) Nathalie Gaudreault et al.   PLoS One

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease

(2011) C Dirk Keene et al.   CURRENT OPINION IN NEUROBIOLOGY

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia

(2011) Dimitra Georgiadou et al.   PLoS One

APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure

(2009) Lynn M. Bekris et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Neurogranin enhances synaptic strength through its interaction with calmodulin

(2009) Ling Zhong et al.   EMBO JOURNAL

Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese

(2009) Norihiro Takei et al.   GENOMICS

Protection of Neurons from Apoptosis by Apolipoprotein E-containing Lipoproteins Does Not Require Lipoprotein Uptake and Involves Activation of Phospholipase Cγ1 and Inhibition of Calcineurin

(2009) Hideki Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall

(2008) Godfrey S. Getz et al.   JOURNAL OF LIPID RESEARCH