Exploring the Potential of Therapeutic Agents Targeted towards Mitigating the Events Associated with Amyloid-β Cascade in Alzheimer’s Disease
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Title
Exploring the Potential of Therapeutic Agents Targeted towards Mitigating the Events Associated with Amyloid-β Cascade in Alzheimer’s Disease
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 20, Pages 7443
Publisher
MDPI AG
Online
2020-10-09
DOI
10.3390/ijms21207443
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Note: Only part of the references are listed.- Protective effects of thymoquinone against acrylamide-induced liver, kidney and brain oxidative damage in rats
- (2020) Mohamed M. Abdel-Daim et al. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain
- (2020) Ramona D’Amico et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Piezoelectric materials for ultrasound-driven dissociation of Alzheimer's β-amyloid aggregate structure
- (2020) Jinhyeong Jang et al. BIOMATERIALS
- Emerging Therapeutic Promise of Ketogenic Diet to Attenuate Neuropathological Alterations in Alzheimer’s Disease
- (2020) Md. Sahab Uddin et al. MOLECULAR NEUROBIOLOGY
- Recent therapeutic strategies targeting beta amyloid and tauopathies in Alzheimer's disease
- (2019) Yamini Madav et al. BRAIN RESEARCH BULLETIN
- MONITORING THE EFFECTS OF VARIOUS COMBINATION OF SPECIFIC DRUG THERAPIES AT DIFFERENT STAGES OF ALZHEIMER′S DEMENTIA
- (2019) LAVINIA PURZA FARMACIA
- Neuroinflammation as a Common Feature of Neurodegenerative Disorders
- (2019) Leonardo Guzman-Martinez et al. Frontiers in Pharmacology
- NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models
- (2019) Ashok Iyaswamy et al. JOURNAL OF FOOD AND DRUG ANALYSIS
- Polyproline chains destabilize the Alzheimer’s amyloid-β protofibrils: A molecular dynamics simulation study
- (2019) Pavan Krishna Kanchi et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Thymoquinone and diallyl sulfide protect against fipronil-induced oxidative injury in rats
- (2018) Mohamed M. Abdel-Daim et al. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- Prion-like seeding and nucleation of intracellular amyloid-β
- (2018) Tomas T. Olsson et al. NEUROBIOLOGY OF DISEASE
- Insulin-Degrading Enzyme in the Fight against Alzheimer’s Disease
- (2018) Igor V. Kurochkin et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases
- (2018) Helena Solleiro-Villavicencio et al. Frontiers in Cellular Neuroscience
- Amyloid-β Aggregation on Model Lipid Membranes: An Atomic Force Microscopy Study
- (2018) Francis Hane et al. JOURNAL OF ALZHEIMERS DISEASE
- Apolipoprotein E and affective symptoms in mild cognitive impairment and Alzheimer’s disease dementia: A systematic review and meta-analysis
- (2018) Leonie C.P. Banning et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- N-Palmitoylethanolamine-Oxazoline as a New Therapeutic Strategy to Control Neuroinflammation: Neuroprotective Effects in Experimental Models of Spinal Cord and Brain Injury
- (2017) Daniela Impellizzeri et al. JOURNAL OF NEUROTRAUMA
- Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications
- (2017) Zewen Liu et al. Oxidative Medicine and Cellular Longevity
- Evidence for Intramolecular Antiparallel Beta-Sheet Structure in Alpha-Synuclein Fibrils from a Combination of Two-Dimensional Infrared Spectroscopy and Atomic Force Microscopy
- (2017) Steven J. Roeters et al. Scientific Reports
- Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
- (2017) Frank Raven et al. EBioMedicine
- GLP-1 Receptor Stimulation Reduces Amyloid-β Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer's Disease
- (2017) Yazhou Li et al. JOURNAL OF ALZHEIMERS DISEASE
- THE AMYLOID-B GENERATING TRI-PEPTIDE CLEAVAGE MECHANISM OF GAMMA-SECRETASE: IMPLICATIONS FOR ALZHEIMER'S DISEASE
- (2016) Michael S. Wolfe et al. Alzheimers & Dementia
- Structural differences between amyloid beta oligomers
- (2016) Leonid Breydo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeted Antioxidant, Catalase-SKL, Reduces Beta-Amyloid Toxicity in the Rat Brain
- (2016) Hayley J. Nell et al. BRAIN PATHOLOGY
- Physiological and pathological roles of the γ-secretase complex
- (2016) Courtney M. Carroll et al. BRAIN RESEARCH BULLETIN
- BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease
- (2016) Robert H. Scannevin et al. NEUROPHARMACOLOGY
- Therapeutic strategies for Alzheimer's disease in clinical trials
- (2016) Justyna Godyń et al. Pharmacological Reports
- Treating transgenic Alzheimer mice with a β-secretase inhibitor, what have we learned?
- (2016) Jordan Tang et al. Aging-US
- Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease
- (2015) Yang Xiang et al. ACTA NEUROPATHOLOGICA
- Palmitoylethanolamide Regulates Production of Pro-Angiogenic Mediators in a Model of β Amyloid-Induced Astrogliosis In Vitro
- (2015) Mariateresa Cipriano et al. CNS & Neurological Disorders-Drug Targets
- Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function
- (2015) Junji Egawa et al. JOURNAL OF PHYSIOLOGY-LONDON
- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution
- (2015) Stephen D. Skaper et al. MOLECULAR NEUROBIOLOGY
- Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway
- (2015) Utpal Das et al. NATURE NEUROSCIENCE
- Clearance systems in the brain—implications for Alzheimer disease
- (2015) Jenna M. Tarasoff-Conway et al. Nature Reviews Neurology
- Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer’s disease
- (2015) Songwei Duan et al. NEUROBIOLOGY OF AGING
- Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment
- (2015) Sylvia Lombardo et al. NEUROPHARMACOLOGY
- The age factor in Alzheimer’s disease
- (2015) Rita Guerreiro et al. Genome Medicine
- How Do Membranes Initiate Alzheimer’s Disease? Formation of Toxic Amyloid Fibrils by the Amyloid β-Protein on Ganglioside Clusters
- (2014) Katsumi Matsuzaki ACCOUNTS OF CHEMICAL RESEARCH
- Neuroprotection by Association of Palmitoylethanolamide with Luteolin in Experimental Alzheimer’s Disease Models: The Control of Neuroinflammation
- (2014) Irene Paterniti et al. CNS & Neurological Disorders-Drug Targets
- Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer’s disease
- (2014) Elizabeth Drolle et al. DRUG METABOLISM REVIEWS
- Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production
- (2014) Kia Strömberg et al. FEBS Journal
- Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer’s Disease
- (2013) Filipa I. Baptista et al. ACS Chemical Neuroscience
- The global prevalence of dementia: A systematic review and metaanalysis
- (2013) Martin Prince et al. Alzheimers & Dementia
- The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity
- (2013) Cristina Cecchi et al. BIOPHYSICAL CHEMISTRY
- Testing synthetic amyloid-β aggregation inhibitor using single molecule atomic force spectroscopy
- (2013) Francis T. Hane et al. BIOSENSORS & BIOELECTRONICS
- Natural Compounds May Open New Routes to Treatment of Amyloid Diseases
- (2013) Jan Bieschke Neurotherapeutics
- Correction: A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease
- (2013) Vadivel Parthsarathy et al. PLoS One
- Physiological Functions of APP Family Proteins
- (2013) U. C. Muller et al. Cold Spring Harbor Perspectives in Medicine
- Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets?
- (2013) Jens Moreth et al. Immunity & Ageing
- Disease Modifying Drugs Targeting β-Amyloid
- (2012) S. N. Ozudogru et al. American Journal of Alzheimers Disease and Other Dementias
- Engineered antibody approaches for Alzheimer’s disease immunotherapy
- (2012) Remy Robert et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Nanoscale Electrostatic Domains in Cholesterol-Laden Lipid Membranes Create a Target for Amyloid Binding
- (2012) Elizabeth Drolle et al. BIOPHYSICAL JOURNAL
- Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony
- (2012) Rodrigo Medeiros et al. EXPERIMENTAL NEUROLOGY
- Estrogen activates matrix metalloproteinases-2 and -9 to increase beta amyloid degradation
- (2012) Sara Merlo et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
- (2012) Iryna Benilova et al. NATURE NEUROSCIENCE
- Current and future treatments for Alzheimer’s disease
- (2012) Konstantina G. Yiannopoulou et al. Therapeutic Advances in Neurological Disorders
- Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies
- (2011) Shalini John et al. BMC BIOINFORMATICS
- γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes
- (2011) Bruno P. Imbimbo et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Single-channel Ca2+imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology
- (2011) Angelo Demuro et al. JOURNAL OF CELL BIOLOGY
- Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)
- (2011) Lei Ma et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
- (2011) Silvestre Alavez et al. NATURE
- Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils
- (2011) Jan Bieschke et al. Nature Chemical Biology
- Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
- (2011) Y. J. Yu et al. Science Translational Medicine
- A Single Ascending Dose Study of Bapineuzumab in Patients With Alzheimer Disease
- (2010) Ronald S. Black et al. ALZHEIMER DISEASE & ASSOCIATED DISORDERS
- Development of a Proteolytically Stable Retro-Inverso Peptide Inhibitor of β-Amyloid Oligomerization as a Potential Novel Treatment for Alzheimer’s Disease
- (2010) Mark Taylor et al. BIOCHEMISTRY
- Activation of mixed glia by Aβ-specific Th1 and Th17 cells and its regulation by Th2 cells
- (2010) K. McQuillan et al. BRAIN BEHAVIOR AND IMMUNITY
- β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice
- (2010) Wan-Pin Chang et al. FASEB JOURNAL
- Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion
- (2010) Irfan Y. Tamboli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Immunotherapy for Alzheimer’s disease
- (2010) D. Morgan JOURNAL OF INTERNAL MEDICINE
- Can Alzheimer disease be prevented by amyloid-β immunotherapy?
- (2010) Cynthia A. Lemere et al. Nature Reviews Neurology
- Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils
- (2010) Mahiuddin Ahmed et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease
- (2010) Maria Z. Kounnas et al. NEURON
- Alzheimer's Disease
- (2010) Henry W. Querfurth et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease
- (2010) Jessica F. Jordão et al. PLoS One
- Common features between diabetes mellitus and Alzheimer’s disease
- (2009) J. Götz et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Implication of Complement System and its Regulators in Alzheimers Disease
- (2009) Martin Kolev et al. Current Neuropharmacology
- -Amyloid Monomers Are Neuroprotective
- (2009) M. L. Giuffrida et al. JOURNAL OF NEUROSCIENCE
- Something Old... Something Blue
- (2009) S. Scheindlin MOLECULAR INTERVENTIONS
- Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)
- (2008) ARCHIVES OF NEUROLOGY
- Designing Peptide Inhibitors for Oligomerization and Toxicity of Alzheimer's β-Amyloid Peptide†
- (2008) Brian M. Austen et al. BIOCHEMISTRY
- The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology
- (2008) Sarah L. Cole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid Precursor Protein Trafficking, Processing, and Function
- (2008) Gopal Thinakaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
- (2008) M D M Haag et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Small-molecule aggregates inhibit amyloid polymerization
- (2008) Brian Y Feng et al. Nature Chemical Biology
- Protective effects of NSAIDs on the development of Alzheimer disease
- (2008) Steven C. Vlad et al. NEUROLOGY
- Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
- (2008) Hui-Ming Gao et al. TRENDS IN IMMUNOLOGY
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