The piperine derivative HJ105 inhibits Aβ1–42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis

APOEε4 potentiates the relationship between amyloid-β and tau pathologies

(2020) Joseph Therriault et al.   MOLECULAR PSYCHIATRY

HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2

(2020) Xiping Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

miRNA-141 Induced Pyroptosis in Intervertebral Disk Degeneration by Targeting ROS Generation and Activating TXNIP/NLRP3 Signaling in Nucleus Pulpous Cells

(2020) Qiaolong Xu et al.   Frontiers in Cell and Developmental Biology

Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1–42 infused rat model

(2020) Birsen Elibol et al.   PHYTOMEDICINE

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice

(2019) Brenna C. Beckelman et al.   JOURNAL OF CLINICAL INVESTIGATION

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

(2019) Zhuo Gong et al.   Journal of Neuroinflammation

Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer’s Disease Brain

(2019) Lexiao Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

(2019) Zehan Tang et al.   Cell Death & Disease

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

(2018) Chun-Yan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Neuroprotective effects of INT-777 against Aβ 1–42 -induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice

(2018) Xian Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Identification of a novel small-molecule Keap1–Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy

(2018) Cheng-Shi Jiang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer’s disease

(2018) Bian-Rong Wang et al.   Journal of Neuroinflammation

miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis

(2018) Zhiqiang Pan et al.   Journal of Neuroinflammation

Piperine ameliorates SCA17 neuropathology by reducing ER stress

(2018) Jifeng Guo et al.   Molecular Neurodegeneration

Icariside II ameliorates ibotenic acid-induced cognitive impairment and apoptotic response via modulation of MAPK pathway in rats

(2018) Lianzi He et al.   PHYTOMEDICINE

Specks of insight into Alzheimer’s disease

(2017) Richard M. Ransohoff   NATURE

Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22

(2017) Ya-Hui Ni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

The Prevalence and Incidence of Dementia Due to Alzheimer’s Disease: a Systematic Review and Meta-Analysis

(2016) Kirsten M. Fiest et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease

(2016) Liqin Zhao et al.   NEUROBIOLOGY OF AGING

Protective effects and mechanism of TPX2 on neurocyte apoptosis of rats in Alzheimer's disease model

(2016) Keshan Liang et al.   Experimental and Therapeutic Medicine

Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson’s disease model

(2016) Jia Liu et al.   Oncotarget

Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

(2015) Sandra I. Mota et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Piperine reverses the effects of corticosterone on behavior and hippocampal BDNF expression in mice

(2014) Qing-Qiu Mao et al.   NEUROCHEMISTRY INTERNATIONAL

Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice

(2014) Jin'e Lai et al.   NEUROPHARMACOLOGY

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s disease

(2012) Osamah B. Al-Baghdadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The use of nitroxide radical-containing nanoparticles coupled with piperine to protect neuroblastoma SH-SY5Y cells from Aβ-induced oxidative stress

(2011) Pennapa Chonpathompikunlert et al.   BIOMATERIALS

Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease

(2009) Pennapa Chonpathompikunlert et al.   FOOD AND CHEMICAL TOXICOLOGY