Stroke and Amyloid-β Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response

Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice

(2019) Yubao Fan et al.   JOURNAL OF CHEMICAL NEUROANATOMY

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders

(2018) Susana Carmona et al.   LANCET NEUROLOGY

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia

(2017) Xiaobao Zhang et al.   MEDIATORS OF INFLAMMATION

A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature

(2017) Efthimios Dardiotis et al.   NEUROBIOLOGY OF AGING

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

(2017) Li Zhong et al.   Frontiers in Aging Neuroscience

The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer’s and Vascular Disease

(2017) Michela Guglielmotto et al.   Frontiers in Aging Neuroscience

Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein

(2016) Giusi Manassero et al.   AGING CELL

TREMs in Alzheimer's disease: Genetic and clinical investigations

(2016) Jia Cheng et al.   CLINICA CHIMICA ACTA

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases

(2016) Jie Han et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease

(2016) Zhe-Min Shi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

(2016) Qiuyang Zheng et al.   Frontiers in Aging Neuroscience

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

(2015) Mythily Srinivasan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration

(2015) Maria E. Figueiredo-Pereira et al.   Frontiers in Molecular Neuroscience

The regulation of the UCH-L1 gene by transcription factor NF-κB in podocytes

(2013) Hongxia Zhang et al.   CELLULAR SIGNALLING

β-Amyloid (Aβ) Oligomers Impair Brain-derived Neurotrophic Factor Retrograde Trafficking by Down-regulating Ubiquitin C-terminal Hydrolase, UCH-L1

(2013) Wayne W. Poon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice

(2013) Teng Jiang et al.   NEUROBIOLOGY OF AGING

Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

(2012) Michela Guglielmotto et al.   AGING CELL

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

NF-κB signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression

(2011) Ruitao Wang et al.   JOURNAL OF NEUROCHEMISTRY

Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1

(2010) L. M. I. Koharudin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFα-mediated vascular smooth muscle cell proliferation via suppressing ERK activation

(2009) Tomonaga Ichikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat

(2008) Preeti Dohare et al.   BEHAVIOURAL BRAIN RESEARCH

NFκB-dependent Control ofBACE1Promoter Transactivation by Aβ42

(2008) Virginie Buggia-Prevot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY