An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

Role of endogenous hydrogen sulfide in cardiac mitochondrial preservation during ischemia reperfusion injury

(2018) Sanhitha Nandi et al.   BIOMEDICINE & PHARMACOTHERAPY

Metabolism of anethole dithiolethione by rat and human liver microsomes: formation of various products deriving from its O-demethylation and S-oxidation. Involvement of cytochromes P450 and flavin monooxygenases in these pathways.

(2018) Martin Dulac et al.   DRUG METABOLISM AND DISPOSITION

Hydrogen Sulfide (H2S)-Releasing Compounds: Therapeutic Potential in Cardiovascular Diseases

(2018) Lei Zhang et al.   Frontiers in Pharmacology

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

(2017) Hoi-Shan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of succinate and ROS in reperfusion injury – A critical appraisal

(2017) Tatyana N. Andrienko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

(2017) Alex Dyson et al.   PLOS MEDICINE

Understanding and preventing mitochondrial oxidative damage

(2016) Michael P. Murphy   BIOCHEMICAL SOCIETY TRANSACTIONS

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Real-Time Fluorescence Measurements of ROS and [Ca2+] in Ischemic / Reperfused Rat Hearts: Detectable Increases Occur only after Mitochondrial Pore Opening and Are Attenuated by Ischemic Preconditioning

(2016) Tatyana Andrienko et al.   PLoS One

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

(2015) John L. Wallace et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic application of hydrogen sulfide donors: the potential and challenges

(2015) Dan Wu et al.   Frontiers of Medicine

Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species

(2015) Ryan J. Mailloux   Redox Biology

Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessedex Vivounder Conditions Mimicking Rest and Exercise

(2014) Renata L. S. Goncalves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Mitochondrial energetics is impairedin vivoin aged skeletal muscle

(2013) Gilles Gouspillou et al.   AGING CELL

Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening

(2013) Adam L. Orr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrially targeted compounds and their impact on cellular bioenergetics

(2013) Colin Reily et al.   Redox Biology

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

(2012) Khosrow Kashfi et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing

(2012) Jan Gruber et al.   BIOTECHNOLOGY ADVANCES

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters

(2012) Casey L. Quinlan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Accurate Determination of the Oxidative Phosphorylation Affinity for ADP in Isolated Mitochondria

(2011) Gilles Gouspillou et al.   PLoS One

Design, synthesis, and pharmacological evaluation of the aqueous prodrugs of desmethyl anethole trithione with hepatoprotective activity

(2010) Pei Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Therapeutic potential of new hydrogen sulfide-releasing hybrids

(2010) Anna Sparatore et al.   Expert Review of Clinical Pharmacology

Lack of Oxygen Deactivates Mitochondrial Complex I

(2009) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria

(2007) Qun Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY