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Title
Metabolic adaptation in hypoxia and cancer
Authors
Keywords
Hypoxia, Pseudohypoxia, Metabolites, TCA
Journal
CANCER LETTERS
Volume 502, Issue -, Pages 133-142
Publisher
Elsevier BV
Online
2021-01-13
DOI
10.1016/j.canlet.2020.12.020
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Note: Only part of the references are listed.- Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium
- (2020) Celia M. Bisbach et al. Cell Reports
- Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression
- (2020) Qingxiang Lin et al. Advanced Science
- Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy
- (2020) Fátima Baltazar et al. Frontiers in Oncology
- Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis
- (2019) Meixi Peng et al. Cell Death & Disease
- Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress
- (2019) Hailong Qi et al. Cell Death & Disease
- Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor
- (2019) Jing-Yiing Wu et al. MOLECULAR CELL
- Metabolic regulation of gene expression by histone lactylation
- (2019) Di Zhang et al. NATURE
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
- (2019) Karen G. de la Cruz-López et al. Frontiers in Oncology
- 2-Oxoglutarate-Dependent Oxygenases
- (2018) Md. Saiful Islam et al. Annual Review of Biochemistry
- NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism
- (2018) Wusheng Xiao et al. ANTIOXIDANTS & REDOX SIGNALING
- The Regulatory Role of NAD in Human and Animal Cells
- (2018) V. A. Kulikova et al. BIOCHEMISTRY-MOSCOW
- Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the α-Ketoglutarate Signaling Pathway
- (2018) Chien-Wei Tseng et al. CANCER RESEARCH
- The redox requirements of proliferating mammalian cells
- (2018) Aaron M. Hosios et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Down-regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer
- (2018) Qiongli Su et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
- (2018) Mani Shankar Babu et al. PLoS One
- α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis
- (2018) Sandra Atlante et al. Cell Death & Disease
- A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation
- (2018) Niamh C. Williams et al. Frontiers in Immunology
- The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
- (2018) Julian Hlouschek et al. Frontiers in Oncology
- Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
- (2018) Maria Apicella et al. Cell Metabolism
- ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism
- (2018) Carlotta Granchi EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- CPT1A-mediated succinylation of S100A10 increases human gastric cancer invasion
- (2018) Chao Wang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
- (2017) Jian-Guo Ren et al. Scientific Reports
- Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer
- (2017) Luisa Iommarini et al. Frontiers in Oncology
- Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use
- (2016) Barbara Zdzisińska et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis
- (2016) Laszlo Tretter et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target
- (2016) Icard Philippe et al. DRUG RESISTANCE UPDATES
- Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling
- (2016) Sergiy M. Nadtochiy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Succinat-Dehydrogenase(SDH)-defizientes Nierenzellkarzinom
- (2016) A. Agaimy PATHOLOGE
- SDHB deficiency promotes TGFβ-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4
- (2016) Haiyu Wang et al. Translational Oncology
- Intermediates of Metabolism: From Bystanders to Signalling Molecules
- (2016) Robert Haas et al. TRENDS IN BIOCHEMICAL SCIENCES
- Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells
- (2016) Bo Li et al. Oncotarget
- Potential role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia
- (2016) Ga Young Lee et al. Oncotarget
- Hypoxia and metabolic adaptation of cancer cells
- (2016) K L Eales et al. Oncogenesis
- DUBs, New Members in the Hypoxia Signaling clUb
- (2016) Amelie S. Schober et al. Frontiers in Oncology
- Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress
- (2015) William M. Oldham et al. Cell Metabolism
- Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer
- (2015) Y. Ni et al. ENDOCRINE-RELATED CANCER
- Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases
- (2015) Suzana Markolovic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor
- (2015) Hanna Tarhonskaya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
- (2015) Katherine Sellers et al. JOURNAL OF CLINICAL INVESTIGATION
- Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization
- (2015) Yuria Saito et al. NEUROCHEMICAL RESEARCH
- Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells
- (2015) Phatchariya Phannasil et al. PLoS One
- Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers
- (2015) Shruti Desai et al. Oncotarget
- Citrate – new functions for an old metabolite
- (2014) Vito Iacobazzi et al. BIOLOGICAL CHEMISTRY
- Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)
- (2014) Margherita Nannini et al. BMC CANCER
- A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation
- (2014) Gopinath Sutendra et al. CELL
- Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway
- (2014) H. Shime et al. JOURNAL OF IMMUNOLOGY
- Comprehensive review on lactate metabolism in human health
- (2014) M. Adeva-Andany et al. MITOCHONDRION
- Citrate Synthase Expression Affects Tumor Phenotype and Drug Resistance in Human Ovarian Carcinoma
- (2014) Lilan Chen et al. PLoS One
- L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer
- (2014) E.-H. Shim et al. Cancer Discovery
- Transcriptional regulation by hypoxia inducible factors
- (2013) Veronica L. Dengler et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells
- (2013) Valérie Desquiret-Dumas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression
- (2013) Antonio F. Santidrian et al. JOURNAL OF CLINICAL INVESTIGATION
- Oncometabolites: linking altered metabolism with cancer
- (2013) Ming Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
- (2013) Z. Husain et al. JOURNAL OF IMMUNOLOGY
- Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
- (2013) Sarah-Maria Fendt et al. Nature Communications
- Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation
- (2013) Brian T. Weinert et al. Cell Reports
- Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition
- (2012) Anne R. Diers et al. BIOCHEMICAL JOURNAL
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes
- (2012) Brian W. Wong et al. TRENDS IN BIOCHEMICAL SCIENCES
- Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy
- (2012) Chin-Chih Lin et al. Scientific Reports
- The emerging role of fumarate as an oncometabolite
- (2012) Ming Yang et al. Frontiers in Oncology
- Lactate: A Metabolic Key Player in Cancer
- (2011) F. Hirschhaeuser et al. CANCER RESEARCH
- Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis
- (2011) F. Vegran et al. CANCER RESEARCH
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
- (2011) Weibo Luo et al. CELL
- The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
- (2011) Rasheduzzaman Chowdhury et al. EMBO REPORTS
- IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
- (2011) M Fernanda Amary et al. JOURNAL OF PATHOLOGY
- Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping
- (2011) D. R. Borger et al. ONCOLOGIST
- Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability
- (2011) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer
- (2010) Avaniyapuram Kannan Murugan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma
- (2010) Francesca Pistollato et al. BIOCHEMICAL PHARMACOLOGY
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Succinate dehydrogenase – Assembly, regulation and role in human disease
- (2010) Jared Rutter et al. MITOCHONDRION
- Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol
- (2010) Ming Zhou et al. Molecular Cancer
- Identification of lysine succinylation as a new post-translational modification
- (2010) Zhihong Zhang et al. Nature Chemical Biology
- Metabolic Modulation of Glioblastoma with Dichloroacetate
- (2010) E. D. Michelakis et al. Science Translational Medicine
- Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response
- (2010) Ohad Yogev et al. PLOS BIOLOGY
- Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
- (2009) Christian Hartmann et al. ACTA NEUROPATHOLOGICA
- Identification of small molecule inhibitors of pyruvate kinase M2
- (2009) Matthew G. Vander Heiden et al. BIOCHEMICAL PHARMACOLOGY
- Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model
- (2009) Ken Matsumoto et al. CANCER SCIENCE
- The mitochondrial citrate carrier: Metabolic role and regulation of its activity and expression
- (2009) Gabriele V. Gnoni et al. IUBMB LIFE
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- Glycolytic metabolism and tumour response to fractionated irradiation
- (2009) Ulrike G.A. Sattler et al. RADIOTHERAPY AND ONCOLOGY
- Analysis of the IDH1 codon 132 mutation in brain tumors
- (2008) Jörg Balss et al. ACTA NEUROPATHOLOGICA
- Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis
- (2008) Hongchang Gao et al. ANALYTICA CHIMICA ACTA
- Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
- (2008) E D Michelakis et al. BRITISH JOURNAL OF CANCER
- ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer
- (2008) T. Migita et al. CANCER RESEARCH
- Metabolic regulation by lactate
- (2008) Mauro Sola-Penna IUBMB LIFE
- Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells
- (2008) Thomas McFate et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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