Neuroprotective Function of High Glycolytic Activity in Astrocytes: Common Roles in Stroke and Neurodegenerative Diseases

The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model

(2021) Nicole J. Sylvain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases

(2021) Mootaz M. Salman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Excitotoxicity as a Target against Neurodegenerative Processes

(2020) Octavio Binvignat et al.   CURRENT PHARMACEUTICAL DESIGN

Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit

(2020) Shinichi Takahashi   NEUROPATHOLOGY

Ropinirole, a New ALS Drug Candidate Developed Using iPSCs

(2020) Hideyuki Okano et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

(2020) Philip Kitchen et al.   CELL

Toll-Like Receptor 4 Signaling in Focal Cerebral Ischemia: a Focus on the Neurovascular Unit

(2020) Bolanle M. Famakin et al.   MOLECULAR NEUROBIOLOGY

Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders

(2020) Divya Dwivedi et al.   NEUROCHEMICAL RESEARCH

Bardoxolone methyl: drug development for diabetic kidney disease

(2020) Hironori Kanda et al.   Clinical and Experimental Nephrology

Pathophysiology of ischemic stroke: role of oxidative stress

(2020) Sofía Orellana-Urzúa et al.   CURRENT PHARMACEUTICAL DESIGN

Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells

(2020) L. Iovino et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Interaction of Microglia and Astrocytes in the Neurovascular Unit

(2020) Li-rong Liu et al.   Frontiers in Immunology

Crosstalk Between Astrocytes and Microglia: An Overview

(2020) Agata Matejuk et al.   Frontiers in Immunology

Antioxidant and Anti-inflammatory Effect of Nrf2 Inducer Dimethyl Fumarate in Neurodegenerative Diseases

(2020) Sarah A. Scuderi et al.   Antioxidants

Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?

(2020) Shane A. Liddelow et al.   TRENDS IN IMMUNOLOGY

Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging

(2020) Mootaz M. Salman et al.   Frontiers in Bioengineering and Biotechnology

Human Astrocytes Model Derived from Induced Pluripotent Stem Cells

(2020) Nicolas Leventoux et al.   Cells

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Neuroprotection by glucose‐6‐phosphate dehydrogenase and the pentose phosphate pathway

(2019) Bor Luen Tang   JOURNAL OF CELLULAR BIOCHEMISTRY

The energetic brain ‐ A review from students to students

(2019) M.P. Bordone et al.   JOURNAL OF NEUROCHEMISTRY

Cerebral Organoids Repair Ischemic Stroke Brain Injury

(2019) Shu-Na Wang et al.   Translational Stroke Research

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway

(2018) Kyoko Mashima et al.   ASN Neuro

Insight into the emerging role of striatal neurotransmitters in the pathophysiology of Parkinson’s disease and Huntington’s disease: A review

(2018) Sumit Jamwal et al.   Current Neuropharmacology

The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle

(2018) Anand Kumar Bachhawat et al.   IUBMB LIFE

How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?

(2018) Kazutoshi Watanabe et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

(2018) Ming-Shuo Sun et al.   Oxidative Medicine and Cellular Longevity

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

Current advances in ischemic stroke research and therapies

(2018) Derek Barthels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroenergetics: Astrocytes Have a Sweet Spot for Glucose

(2018) Luc Pellerin   CURRENT BIOLOGY

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

Early Prediction of Malignant Brain Edema After Ischemic Stroke

(2018) Simiao Wu et al.   STROKE

Hypothermia increases aquaporin 4 (AQP4) plasma membrane abundance in human primary cortical astrocytes via a calcium/transient receptor potential vanilloid 4 (TRPV4)- and calmodulin-mediated mechanism

(2017) Mootaz M. Salman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Oligodendroglia: metabolic supporters of neurons

(2017) Thomas Philips et al.   JOURNAL OF CLINICAL INVESTIGATION

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

(2017) Gerald A. Dienel   JOURNAL OF NEUROSCIENCE RESEARCH

Suppression of TLR4/NF-κB Signaling Pathway Improves Cerebral Ischemia–Reperfusion Injury in Rats

(2017) Hang Zhao et al.   MOLECULAR NEUROBIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Pathogenic mechanisms following ischemic stroke

(2017) Seyed Esmaeil Khoshnam et al.   NEUROLOGICAL SCIENCES

The metabolic trinity, glucose–glycogen–lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression

(2017) Gerald A. Dienel   NEUROSCIENCE LETTERS

Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia

(2017) Mootaz M. Salman et al.   Frontiers in Cellular Neuroscience

Dimethyl fumarate for ischemic stroke

(2017) Reiner Kunze   Oncotarget

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation

(2017) Youichi Shinozaki et al.   Cell Reports

Edaravone and its clinical development for amyotrophic lateral sclerosis

(2017) Koji Takei et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

(2017) Leslie Mazuel et al.   PLoS One

Bioenergetics and redox adaptations of astrocytes to neuronal activity

(2016) Juan P. Bolaños   JOURNAL OF NEUROCHEMISTRY

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

(2016) Takuya Iizumi et al.   Journal of Neuroinflammation

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

(2016) Mayank Goyal et al.   LANCET

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge

(2015) Diana M. Norden et al.   GLIA

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Roles and Regulation of Ketogenesis in Cultured Astroglia and Neurons Under Hypoxia and Hypoglycemia

(2014) Shinichi Takahashi et al.   ASN Neuro

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

(2014) Anna Stincone et al.   BIOLOGICAL REVIEWS

PPAR-γImpairment Alters Peroxisome Functionality in Primary Astrocyte Cell Cultures

(2014) Lorenzo Di Cesare Mannelli et al.   Biomed Research International

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oligodendroglia: metabolic supporters of axons

(2013) Brett M. Morrison et al.   TRENDS IN CELL BIOLOGY

Astroglial Pentose Phosphate Pathway Rates in Response to High-Glucose Environments

(2012) Shinichi Takahashi et al.   ASN Neuro

Very Long Chain Fatty Acid ^|^#946;-Oxidation in Astrocytes: Contribution of the ABCD1-Dependent and -Independent Pathways

(2012) Masashi Morita et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

White-Matter Astrocytes, Axonal Energy Metabolism, and Axonal Degeneration in Multiple Sclerosis

(2012) Melissa Cambron et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Neuroprotective mechanisms of hypothermia in brain ischaemia

(2012) Midori A. Yenari et al.   NATURE REVIEWS NEUROSCIENCE

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pioglitazone enhances pyruvate and lactate oxidation in cultured neurons but not in cultured astroglia

(2009) Yoshikane Izawa et al.   BRAIN RESEARCH

Relationship of Neurovascular Elements to Neuron Injury during Ischemia

(2009) Gregory J. del Zoppo   CEREBROVASCULAR DISEASES

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Toxic effects of dopamine metabolism in Parkinson's disease

(2009) Nobutaka Hattori et al.   PARKINSONISM & RELATED DISORDERS

Inflammation and the neurovascular unit in the setting of focal cerebral ischemia

(2008) G.J. del Zoppo   NEUROSCIENCE

Edaravone Attenuates Brain Edema and Neurologic Deficits in a Rat Model of Acute Intracerebral Hemorrhage

(2007) Takehiro Nakamura et al.   STROKE